抑制...

From the viewpoint of life-span development, inhibitory function of emotional interference matures early and ages slowly. Inhibitory processing of emotional interference occurred earlier and continued longer than neutral interference on the time course. Besides, the anterior cingulated cortex plays an important role in emotional and non-emotional interference inhibition, and the inhibitory attention effects for emotional interference occurred in visual processing.

从终生发展来看，对情绪性干扰的抑制成熟得早且不易老化；从加工时程上看，对情绪性干扰的加工比对非情绪中性干扰的加工在发生得早且持续时间长；从参与加工的脑区来看，大脑内侧额叶前扣带回在情绪与非情绪干扰抑制中发挥重要作用，同时，视觉区中存在对情绪干扰的抑制加工。

In our system, we were unable to detect the cleavage product of overexpressed slit2. Nevertheless, it is interesting to investigate whether the cleavage of slit2 is important for its responsible function in CL1-5 or not. Our result showed that a non-cleavable slit2 showed similar growth inhibitory ability as the cleavable slit2. Therefore, the growth inhibitory ability of slit2 does not require cleavage at the reported cleavage site.

结果显示，在CL1-5细胞中，我们没有侦测到Slit2被切割的情形，并且当不能被切割的Slit2蛋白表现在CL1-5时，其抑制生长的能力与可被切割的Slit2相同，因此这个报导中的切割点与Slit2抑制生长的功能无关，而单独过度表现Slit2-C terminal蛋白片段就具有抑制细胞生长的能力。

We also showed that coadministration of AG825 or AG1478 will enhance the efficacy of cytotoxic AGent cisplatin.

了解5种人类非小细胞肺癌细胞系A549、H322、H358、H460、H1299的HER2和EGFR蛋白表达水平，探讨5种细胞系HER2蛋白表达水平与顺铂IC50之间的关系；观察HER2和EGFR小分子酪氨酸激酶抑制剂AG825和AG1478对5种细胞系的生长抑制作用；观察AG825、AG1478联合顺铂对5种细胞系的协同生长抑制作用；研究AG825、AG1478联合顺铂对H322、H1299细胞系细胞增殖、细胞周期、细胞凋亡和坏死的影响；研究AG825、AG1478联合顺铂所致H322、H1299细胞系EGFR、磷酸化ERK和总ERK表达的变化，探讨协同生长抑制作用的机制。

A dose-dependent inhibition of cGMP-PDE activity was observed when cUMP 10~(-6-10~(12) M was added to the culture medium, which may explain the increase of the level of intracellular cGMP, while the activity of cAMP...

浓度为10~(-6)-10~(-12)McUMP对胞内cAMP-PDE活性几乎没有影响，而抑制cGMP-PDE的活性，抑制作用随cUMP浓度降低而减小，这可能是胞内cGMP水平增高的原因。cUMP可能与细胞的cAMP PK结合，释放催化亚单位，细胞生长的抑制可由此发生。

The growth inhibiting rate of T24 cell lines were detected by MTT methods, apoptosis of cells were detected by flow cytometry, the mechanism of apoptosis was analyzed by detecting the protein expression of Bcl-2, Bax, Caspase-9, Caspase-3 and cytoplastic protein Cytochrome C. 4 We injected live T24 cells into the subcutaneous space of nude mice and successfully built up the animal model of bladder carcinoma. The effect of CS-PAA-EPI polymer magnetic microspheres targeting chemotherapy was investigated by HE staining, TUNEL ,tumor weight and volume inhibition rate. Results: 1 TEM revealed that the CS-PAA polymer magnetic microspheres were regular spherical shape,the average diameter was 80nm in dry condition. By controlling the pH value of the medium,polymers had positive or negative zeta potential. VSM showed the CS-PAA polymer magnetic microspheres had superparamagnetic. The diameter of CS-PAA-EPI polymer magnetic microspheres were 200nm in solution by DLS examining,the embedding ratio was 20%,the EPI loading rate was 15%, which was higer than reported in other articles. 2 Raw eye observation found that the rat"s bladder of treatment group was brown color,which meaned the aggregation of iron particles, compared with the control group, iron stain found iron particles were assembled in rat"s bladder of the treatment group, the amount of iron particles in liver and spleen were less obviously.

研究结果：1合成的CS-PAA磁性聚合物微球呈球形，大小均一，TEM测定其干态下粒径为80nm左右，磁化曲线证实具有超顺磁性，具有一定的PH敏感性，固载表柔比星后，水溶液性状稳定，无沉淀物，DLS测定直径约200nm左右，测定载药率为15％，较文献报道高，包封率为20％。2肉眼观察试验组大鼠膀胱表面呈褐色，可见大量的Fe粒子聚集，普鲁士兰染色法显示，试验组大鼠膀胱壁内有大量的Fe粒子，分布至膀胱壁全层，与对照组大鼠相比，试验组大鼠的肝、脾内的Fe粒子聚集量明显降低；HPLC测定结果与Fe染色相同；高剂量磁性CS-PAA-EPI生理盐水组及单纯EPI生理盐水组均在给药后14天出现血肌酐和尿素氮的升高，其他组大鼠血生化指标没有明显变化。3MTT法发现，高、中、低剂量磁性CS-PAA-EPI生理盐水组在外加磁场的协同作用下杀伤T24细胞效应明显高于单纯的EPI生理盐水组，FCM发现试验药物组可引起明显的肿瘤细胞凋亡，试验药物治疗组细胞胞浆内出现了由线粒体释放出的细胞色素C，试验组细胞Bcl-2蛋白减少，Bax蛋白变化不明显，Caspase-3、Caspase-9蛋白受到了激活活化。4高、中、低剂量磁性CS-PAA-EPI生理盐水组的瘤重抑制率和瘤体积抑制率均明显高于单纯的EPI生理盐水组(P＜0.01)，其中高剂量组的抑制率最高。

The inhibition level by daphnetin for 1, 2, 3 and 4 h were 7%, 51%, 69% and 75% respectively, while the values treated by daphnetin-Fe complex were 8%, 6%, 11% and 9% respectively. The inhibition level by daphnetin at different concentrations （0.1, 1, 100 and 1 mmol/L） for 6 h was 3%, 31%, 58% and 93% respectively and while the values treated by daphnetin-Fe complex were 8%, 6%, 11% and 9%.

经瑞香素（100 μmol/L）作用1、2、3和4 h后RNR活性分别被抑制7%、51%、69%和75%；在瑞香素浓度为0.1、1、100和1 000 μmol/L，作用6 h后，RNR活性分别被抑制3%、31%、58%和93%；而瑞香素-Fe复合物作用6 h后RNR活性分别被抑制8%、6%、11%和9%。

Result The parasites synchronized with sorbitol in vitro was treated by daphnetin and daphnetin-Fe complex.

经瑞香素（100μmol／L）作用1、2、3和4h后RNR活性分别被抑制7％、51％、69％和75％；在瑞香素浓度为0.1、1、100和1000μmol／L，作用6h后，RNR活性分别被抑制3％、31％、58％和93％；而瑞香素-Fe复合物作用6h后RNR活性分别被抑制8％、6％、11％和9％。

The experiment selected a slow release fertilizer and studied the best dosage proportion of the slow fertilizer, dipotassium hydrogen phosphate, DCD as an inhibitor.

对几种有机脲酶抑制剂的抑制效果研究表明，一定浓度的游离态草炭土腐植酸和风化煤腐植酸，对土壤中脲酶活性都有较好的抑制作用，都是良好的有机脲酶抑制剂。

Our prophase research found that A_3 was the most effective component on the inhibition of the myometrium contraction and dysmenorrheal which was related to inhibiting PGs.

我们前期的研究发现：A_3为当归挥发油中最佳抑制子宫收缩、抗痛经活性部位，其抑制子宫收缩机制可能与抑制PGs生成有关。

The hypermethylation of 5 CpG in promoter region serves as a mechanism of the inactivation of RASSF1A gene. This mechanism has been widely confirmed in multiple tumorgenesis including prostate carcinoma cell line DU145. Object Our study is to disclose the epigenic mechanism of the carcinogenesis of prostate cancer. Including: 1. We use demethylation agents in combination with chemotherapeutic drugs, to disclose whether demethylation agents can enhance the anticancer effect of chemotherapeutic drugs. 2. to study whether demethylation drugs can affect the methylation level of RASSF1A gene in.

目的 本研究旨在探讨前列腺癌的表遗传学发生发展机制，包括： 1、甲基化抑制剂与多种化疗药物联合应用，探讨二者间的协同作用，增强化疗药物疗效； 2、体外应用甲基化抑制剂对前列腺癌细胞DU145的RASSF1A基因甲基化水平的影响； 3、体外应用甲基化抑制剂对前列腺癌细胞DU145的RASSF1A基因及蛋白表达的影响，以期为进一步深入探索通过改变抑癌基因的甲基化而为前列腺癌发生机制和基因治疗提供有意义的数据和理论依据。

The labia have now been sutured together almost completely.The drains and the Foley catheter come out at the top.

此刻阴唇已经几乎完全的缝在一起了，排除多余淤血体液的管子和Foley导管从顶端冒出来。

To get the business done, I suggest we split the difference in price.

为了做成这笔生意，我建议我们在价格上大家各让一半。