托马西娜

Antigene peptide nucleic acid specifically inhibits MYCN expression in human neuroblastoma cells leading to cell growth inhibition and apoptosis Roberto Tonelli,Stefania Purgato,Consuelo Camerin,Raffaele Fronza,Fabrizio Bologna,Simone Alboresi,Monica Franzoni,Roberto Corradini,Stefano Sforza,Andrea Faccini,Jason M. Shohet,Rosangela Marchelli,and Andrea Pession Department of Pediatrics, University of Bologna,Sant'Orsola-Malpighi Hospital, Bologna, Italy; Department of Organic and Industrial Chemistry, University of Parma, Parma,Italy; and 3Center for Cell and Gene Therapy, Texas Children's Cancer Center, Baylor College of Medicine, Houston, Texas Abstract We developed an antigene peptide nucleic acid for selective inhibition of MYCN transcription in neuroblastoma cells, targeted against a unique sequence in the antisense DNA strand of exon 2 of MYCN and linked at its NH2 terminus to a nuclear localization signal peptide.

抗原肽核酸抑制MYCN具体表达的神经母细胞瘤细胞，导致细胞生长的抑制和凋亡罗伯托利，斯特凡Purgato ，苏埃洛卡默琳，拉菲尔Fronza ，梅奥尼博洛尼亚，西蒙娜Alboresi ，莫妮卡弗兰索尼，罗伯托Corradini ，斯特凡诺斯福尔扎，安德烈Faccini ，杰森先生Shohet ， Rosangela Marchelli ，和安德烈Pession儿科，博洛尼亚大学，圣' Orsola -马尔皮基医院，博洛尼亚，意大利；有机部和工业大学化学帕尔马，帕尔马，意大利和3Center的细胞和基因治疗，德州儿童癌症中心， Baylor医学院，得克萨斯州休斯敦摘要我们开发了一种抗原肽核酸的选择性抑制神经母细胞瘤MYCN转录细胞，针对一个独特的序列反义DNA链的第2外显子，并与在MYCN 其氨基端为核定位信号肽。

This problem dates back to 1611, when Johannes Kepler conjectured that the best packing arrangement for identical spheres was arranging them in what is now called face centered cubic packing - similar to how one sees cannon balls stacked.

这个问题可追溯到1611年约翰尼斯·开普勒提出堆积等大球体最佳方法的猜想（译者注：当等大球体按照--球心位于正方体各面的中心上--的形式，并且将第一层摆放成六角形时，它们占用的空间最小，对空间的利用率可以超过74%），现在把这个方法叫做面心立体堆积法--类似于加农炮弹的堆积方式。1998年，安娜堡密西根大学教授托马斯·C·黑尔斯证明了这个猜想。

By Hadrian he was given in adoption to Aurelius,13 when Hadrian, making abundant provision for the succession, wished to make Pius his son and Marcus his grandson; and he was given on the condition that he should espouse the daughter of Pius.14 She was later given to Marcus, however, as we have related in his life,15 because Verus seemed too much her junior in years, while Verus took to wife Marcus' daughter Lucilla.16 He was reared in the House of Tiberius,17 and received instruction from the Latin grammarian Scaurinus (the son of the Scaurus18 who had been Hadrian's teacher in grammar), the Greeks Telephus, Hephaestio, Harpocratio, the rhetoricians Apollonius, Caninius Celer,19 Herodes Atticus, and the Latin Cornelius Fronto, his teachers in philosophy being Apollonius20 and Sextus.21 For all of these he cherished a deep affection, and in return he was beloved by them, and this despite his lack of natural gifts in literary studies.

他被哈德良交给奥利留斯收养（13），当时哈德良正忙于为王位的继承作准备，打算让皮乌斯成为他的儿子，而马尔库斯成为他的孙子；他本来预备要娶皮乌斯的女儿（14）。但她后来嫁给了马尔库斯，如我们在他的传记里说的（15），因为维鲁斯的年龄太小了，后来他娶了马尔库斯的女儿露西娜（16）。他在台伯河上的家里长大（17），由拉丁文法家萨卡林努斯（哈德良的文法教师萨卡路斯（18）的儿子），希腊人特里福斯，赫菲斯提奥，哈波卡提奥，修辞学者阿波罗纽斯，卡林留斯。克涅尔（19），赫路德斯。阿提库斯，和拉丁人克列留斯。弗隆托教导。他的哲学教师是阿波罗纽斯（20）和塞图斯（21）。他对他们都怀着深深的珍爱，反过来，他也被他们所爱，尽管他在文学方面没什么天赋。

With the total number of works published amounting to almost 190 million, Diogenes has so far released more than 5,800 titles, out of which more than 2,000 are still available. These include classics such as Montaigne, Shakespeare, Moliere, Flaubert, Stendhal, Balzac, Dickens, Tolstoy, Chekhov; modern classics such as Georges Simenon, William Faulkner, F. Scott Fitzgerald, George Orwell, Carson McCullers, Patricia Highsmith; bestselling authors such as John Irving, Paulo Coelho, Donna Leon; and equally successful German-speaking writers such as Alfred Andersch, Friedrich D rrenmatt, Urs Widmer, Hugo Loetscher, Ingrid Noll, Jakob Arjouni, Erich Hackl, Bernhard Schlink, Doris D rrie, Martin Suter and Patrick S skind.

他们的作者名单包括了经典作家蒙田、莎士比亚、莫里哀、福楼拜、司汤达、巴尔扎克、狄更斯、托尔斯泰、契诃夫，现代经典作家乔治·西默农、威廉·福克纳、司各特·菲茨杰拉德、乔治·奥威尔、卡森·麦卡勒斯，派翠西亚·海史密斯，畅销书作家约翰·欧文、保罗·科埃略、唐娜·莱昂，还有同样出色的德语作家们，如艾尔弗雷德·安德森、弗里德里克·迪伦马特、乌尔斯·维特默尔，胡戈·罗彻尔，英格丽特·诺尔，雅各布·阿约尼，埃里希·海克尔，本哈德·施林克，桃丽丝·多利，马丁·苏特和帕特里克·聚斯金德。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。