托托

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

The sulfamate moiety in the structure of topiramate is chemically related to known CA inhibitors, and in fact, topiramate inhibits CA activity. To further explore the pharmacological action of topiramate, and clarify the possibility of anti-tumor growth and metastasis of CA inhibitors and its relation with AQP1, we studied the effect of topiramate on adhesion of high metastatic prostate carcinoma to laminin, and established the spontaneous metastatic model of Lewis lung carcinoma to studied the influences of topiramate on tumor growth and metastasis and AQP1 expression in lungs and primary tumors of mice.

为了深入研究托吡酯的药理作用，阐明CA抑制剂和水通道蛋白AQP1相互作用影响肿瘤生长和转移的可能性及其机制，我们研究了托吡酯对高转移的前列腺癌细胞粘附于基质成分层粘连蛋白的影响；以Lewis肺癌自发性转移为模型，考察了托吡酯对肿瘤生长和转移的影响；同时观察了托吡酯对荷瘤小鼠肺组织及原发瘤组织AQP1表达的影响；检测了其对血管新生的作用；利用体外AQP1表达模型，研究了CA抑制剂对AQP1功能的影响；此外，用蛋白质组学的关键技术，通过对模型组与托吡酯治疗组血清蛋白质组的比较分析，来寻找与肿瘤转移相关的蛋白质，探索托吡酯的可能作用靶点。

Rossi's first official challenge will be the Intertoto Cup, as Lazio begin their campaign with the Third Round on July 16 or 17 against one out of Skala Itrottarfelag, Tampere United and Charleroi.

Rossi 的第一个正式挑战是托托杯，lazio将在第三轮7.16或17号对那三个队之一

Lazio is troubled with several injuries ahead of this weekend's season starter against Tampere in the Intertoto cup.

拉齐奥受到了数名伤员的困扰，在这周末与Tampere队的国际托托杯的比赛之前。

Thomas De Quincey 托马斯·德·昆西(1785-1859) is one of the keenest intellects of the age; yet his wonderful intellect seems always subordinate to his passion for dreaming.

托马斯·德·昆西(1785-1859)也是当时最热情的文人，他的学识才智又常常隶属于他美妙的憧憬。

The first difference lies in the fact that Bresson and维尔托夫first consider the movies are filming process, and consider Eisenstein put focus on editing steps, that is, images of organizational processes.

第一个不同之处在于，布莱松和维尔托夫首先考虑的是电影的拍摄过程，而爱森斯坦则把思考的重心放在剪辑的步骤，即影像的组织过程。

The finger-length Ouachita madto沃希托河lives only in the Saline River in Arkansas.

手指长度的沃希托河的madto生活仅仅在含盐分河流在阿肯色州。

Lloyd Nicolson,布里斯托尔（I'm a chartered physio at Bristol City and we had a young lad with aninjury almost identical to your own.

我是布里斯托尔的一位特许理疗师。我们以前治疗过一个和你病情相似的小伙子，他是2009年9月最后一周受的伤。

Companies in major U.S. cities such as: New York, Los Angeles, San Francisco, Chicago, Dallas, such as Canada: Toronto, Vancouver and other places are equipped with Acting branch in Europe such as:菲利克斯托, Andrew Wei-pu, Hamburg, Rotterdam, Oslo, Gothenburg, Dublin, Genoa, such as South America: Rio de Janeiro, Sao Paulo, Iquique, Buenos Aires; Southeast Asia, Taiwan, Korea, Singapore, Pakistan's Karachi, such as the Oceania: Australia, and other companies to The network is also a good agent.

公司于美国各大城市如：纽约，洛杉机，三藩市，芝加哥，达拉斯；加拿大如：多伦多，温哥华等地均设有代理分公司；在欧洲如：菲利克斯托，安特维普，汉堡，鹿特丹，奥斯陆，哥德堡，都柏林，热那亚；南美如：里约热内卢，圣保罗，伊基克，布宜诺斯艾利斯；东南亚的台湾，韩国，新加坡，巴基斯坦的卡拉奇，大洋州如：澳大利亚等地公司亦有良好的网络代理公司。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。