托

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis. CA inhibition may not be an important contributor since CA II expression and CA activity was intact in anhidrotic mice treated with topiramate.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

In summary, our results indicate that hypohidrosis is a frequent adverse effect in children with topiramate therapy. Younger age and hot weather rather than drug dosage are independent risk factors for topiramate-associated hypohidrosis. The resultes also rule out the possibility that topiramate act on its known mechanisms of action, such as potentiating GABA activity at GABAA receptors and antagonizing the AMPA/KA subtype of glutamate receptor in the secretory cells of sweat glands to inhibit sweat secretion. Our data also suggest that topiramate impairs sudomotor function in mice and leads to a significant reduction in AQP5 expression in sweat glands of anhidrotic mice, thus raising the possibility that dysregulation of AQP5 may contribute to topiramate related hypohidrosis.

综合全部实验结果，本研究提示：夏季和低龄是托吡酯引起泌汗障碍的主要危险因素，而托吡酯剂量对泌汗(来源：A44B8787C论文网www.abclunwen.com)功能的影响较小；托吡酯可以抑制小鼠汗液的分泌，小鼠的年龄并不影响这种抑制作用，但托吡酯对小鼠体温无明显影响；托吡酯并不是通过对GABAA受体及AMPA和KA两种谷氨酸受体亚型的作用而在汗腺分泌细胞抑制泌汗；托吡酯不影响汗腺形态及Na，K-ATP酶活性；汗腺分泌细胞的AQP5功能失调可能与托吡酯引起的泌汗障碍密切相关，而碳酸酐酶抑制作用并不是泌汗功能损害的主要原因。

Thus, then, did her feet bear the goddess to Olympus, and meanwhile the Achaeans were flying with loud cries before murderous Hector till they reached the ships and the Hellespont, and they could not draw the body of Mars's servant Patroclus out of reach of the weapons that were showered upon him, for Hector son of Priam with his host and horsemen had again caught up to him like the flame of a fiery furnace; thrice did brave Hector seize him by the feet, striving with might and main to draw him away and calling loudly on the Trojans, and thrice did the two Ajaxes, clothed in valour as with a garment, beat him from off the body; but all undaunted he would now charge into the thick of the fight, and now again he would stand still and cry aloud, but he would give no ground.

就这样，快腿把她带往俄林波斯的峰峦，与此同时，面对杀人狂赫克托耳的进攻，阿开亚人发出可怕的惨叫，撒腿奔逃，退至海船一线，漫长的赫勒斯庞特沿岸。战地上，胫甲紧固的阿开亚人无法从漫天飞舞的枪械里拖＠帕特罗克洛斯的遗体，阿基琉斯的伴从；特洛伊兵勇和车马再次骚拥到帕特罗克洛斯身边，赫克托耳，普里阿摩斯之子，凶狂得像一团火焰。一连三次，光荣的赫克托耳从后面抓起他的双脚，试图把他拖走，高声呼喊着特洛伊人，一连三次，两位骠悍狂烈的埃阿斯将他打离尸躯。但赫克托耳坚信自己的勇力，继续冲扑，时而杀人人群，时而挺腿直立，大声疾呼，一步也不退让。

Methods :Sixty patients with CHF were randomly divided into routine therapy group(control group,n=18),which were administered cardiotonic,diuretic and vascellum expander;low dose atorvastatin group (n=20)and high dose atorvastatin group (n=22),which were supplemented by atorvastatin 10mg/day and 40mg/day separately, besides the routine therapy for 8 weeks.

60例CHF患者分为3组，对照组(n=18)常规予强心、利尿和血管扩张剂治疗，小剂量阿托伐他汀组(n=20)在前者基础上加用阿托伐他汀片(10mg/d)，大剂量阿托伐他汀组(n=22)则在基础治疗上加用阿托伐他汀片(40mg/d)，各治疗8周。

First, this article introduced 2 grade of rotary kiln principle of work and the equipment, to rolled the circle mechanics behavior to carry on the analysis, proposed - rolled the circle - under roller's rotary kiln overall modelling based on the tube body - kiln liner - big tooth ring, to rolled the circle - under roller's contact stress to carry on the finite element analysis the method, and obtained rolled the circle contact stress the size and the distribution rule, finally indicated that rolled the circle contact stress mainly to have two main peak values and the sudden change in one week, appeared is rolling the circle and the under roller contact area; Then, rolls the circle the stress to regard as is the principal stress unknown plane stress test, the use quite mature modern test technology, proposed rolls the circle stress test the principle and the plan, and to rolled the circle the stress to carry on the scene test, the stress which the scene test analysis result and the finite element analysis calculated has compared, had proven the whole method modelling's finite element analysis method's rationality and rolled the circle - under roller contact stress the result accuracy; Finally, uses ANSYS APDL the re-development technology, in view of 2 grades of rotary kilns, rolled the circle - under roller contact stress the overall finite element analytic method to carry on the re-development.

首先，本文介绍了2档回转窑工作原理和装置，对滚圈的力学行为进行了分析，提出了基于筒体-窑衬-大齿圈-滚圈-托轮的回转窑整体建模，对滚圈-托轮的接触应力进行有限元分析的方法，并得到了滚圈接触应力的大小和分布规律，结果表明滚圈接触应力在一周内主要存在两个主要的峰值和突变，都出现在滚圈与托轮接触区域；然后，把滚圈的受力看成是主应力未知的平面应力的测试，利用比较成熟的现代测试技术，提出了滚圈应力测试的原理和方案，并对滚圈的应力进行了现场测试，现场测试分析结果与有限元分析计算出的应力相比较，证明了整体法建模的有限元分析方法的合理性和滚圈-托轮接触应力的结果的正确性；最后，利用ANSYS的APDL的二次开发技术，针对2档回转窑，就滚圈-托轮接触应力的整体有限元分析法进行了二次开发。

The sulfamate moiety in the structure of topiramate is chemically related to known CA inhibitors, and in fact, topiramate inhibits CA activity. To further explore the pharmacological action of topiramate, and clarify the possibility of anti-tumor growth and metastasis of CA inhibitors and its relation with AQP1, we studied the effect of topiramate on adhesion of high metastatic prostate carcinoma to laminin, and established the spontaneous metastatic model of Lewis lung carcinoma to studied the influences of topiramate on tumor growth and metastasis and AQP1 expression in lungs and primary tumors of mice.

为了深入研究托吡酯的药理作用，阐明CA抑制剂和水通道蛋白AQP1相互作用影响肿瘤生长和转移的可能性及其机制，我们研究了托吡酯对高转移的前列腺癌细胞粘附于基质成分层粘连蛋白的影响；以Lewis肺癌自发性转移为模型，考察了托吡酯对肿瘤生长和转移的影响；同时观察了托吡酯对荷瘤小鼠肺组织及原发瘤组织AQP1表达的影响；检测了其对血管新生的作用；利用体外AQP1表达模型，研究了CA抑制剂对AQP1功能的影响；此外，用蛋白质组学的关键技术，通过对模型组与托吡酯治疗组血清蛋白质组的比较分析，来寻找与肿瘤转移相关的蛋白质，探索托吡酯的可能作用靶点。

Chang Jia direct selling all kinds of perennial driving drum, bend drum, electric drum, drum magnetic separator, the trough roller, roller transition, the buffer roller, friction-aligning roller, parallel roller, cleaning, roller, reducer, Motors, housings, couplings, coupling, brakes, Nizhi, conveyors, roller stamping parts and mining machinery, and other components.

常年厂价直销各种传动滚筒、改向滚筒、电动滚筒、磁选滚筒、槽形托辊、过渡托辊、缓冲托辊、摩擦调心托辊、平行托辊、清扫器、辊子、减速机、电机、轴承座、联轴器、偶合器、制动器、逆止器、输送带、托辊冲压件及矿山机械等部件。

The finger-length Ouachita madto沃希托河lives only in the Saline River in Arkansas.

手指长度的沃希托河的madto生活仅仅在含盐分河流在阿肯色州。

Lloyd Nicolson,布里斯托尔（I'm a chartered physio at Bristol City and we had a young lad with aninjury almost identical to your own.

我是布里斯托尔的一位特许理疗师。我们以前治疗过一个和你病情相似的小伙子，他是2009年9月最后一周受的伤。

Companies in major U.S. cities such as: New York, Los Angeles, San Francisco, Chicago, Dallas, such as Canada: Toronto, Vancouver and other places are equipped with Acting branch in Europe such as:菲利克斯托, Andrew Wei-pu, Hamburg, Rotterdam, Oslo, Gothenburg, Dublin, Genoa, such as South America: Rio de Janeiro, Sao Paulo, Iquique, Buenos Aires; Southeast Asia, Taiwan, Korea, Singapore, Pakistan's Karachi, such as the Oceania: Australia, and other companies to The network is also a good agent.

公司于美国各大城市如：纽约，洛杉机，三藩市，芝加哥，达拉斯；加拿大如：多伦多，温哥华等地均设有代理分公司；在欧洲如：菲利克斯托，安特维普，汉堡，鹿特丹，奥斯陆，哥德堡，都柏林，热那亚；南美如：里约热内卢，圣保罗，伊基克，布宜诺斯艾利斯；东南亚的台湾，韩国，新加坡，巴基斯坦的卡拉奇，大洋州如：澳大利亚等地公司亦有良好的网络代理公司。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。