成骨的

Then the cultivated chondrocytes were embedded in fibrin glue fused on spongy bone, covered with priosteal flap; the complex was used to repair the femoral trochlea osteochondral defect which size is 3mm × 4mm × 4mm made in rabbit knee joint.

在A组的每只兔子的一侧膝关节股骨滑车部人为造成3mm×4mm的骨软骨缺损，骨刀切除软骨下骨到髓腔渗血为止(厚约4mm)，压迫后FG止血；取髂骨骨块，并尽可能保留松质骨，取下的骨块用PBS反复清洗，以除去血细胞，将松质骨填充在骨缺损处，松质骨面朝向关节腔，高度与周边软骨下骨齐平，把骨膜片生发层朝向关节腔，用无创伤缝合线缝合在周边的软骨或滑膜组织上；向EP管中加入1/2悬液体积的FG主体胶溶液并混匀，再与主体胶等体积的催化剂溶液一同注射入骨膜与骨块密闭的腔隙中；同理处理另一侧膝关节。B组处理与A组相比只是不加入软骨细胞；C组造成骨软骨缺损，FG覆盖创面后单纯用骨膜修复缺损。

Miyamoto A, Shigematsu T, Fukunaga T, et al. Medical baseline data collection on bone and muscle change with space flight［J］. Bone, 1998, 22(5):7982.［2］ Otto F, Thoenell AP, Crompton T, et al. Cbfα1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblasts differentiation and bone development ［J］.

讨论 FSS对成骨细胞功能的影响骨骼按遗传基因的调控建设骨骼的雏形，并在骨的生长发育中根据所承受载荷的需要对自身不断地进行改建与重塑，以试图实现用最小的骨量达到最大的骨强度，这就是骨的功能适应性。

Results :①The MVs were formed by osteoblast of the secret type、dentinoblast and process;② There was a mature process of the MVs in the extracellular matrix.The appearance of the hydroxyapatite was a major mature feature;③ HAP formed initially in the MVs entered into collage matrix and eventually mineralized;④ The shifting sign of HAP from MVs to the surface of collage fibril was observed.

结果：①MVs是由分泌型成骨细胞、成牙本质细胞及其突起芽生进入胶原基质；②MVs在细胞外胶原基质中有一个逐渐成熟的过程，并以羟基磷灰石（hydroxyapatite，HAP）晶体的出现为其主要特征；③HAP在MVs内形成、增多，最终进入胶原基质并进一步沉积、钙化；④部分胶原原纤维表面沉积的HAP 晶体与MVs分泌的晶体有明显的移形迹象。

AOPA, by "multiple relevant convergence reaction", adjusts and affects systematically the endocrinal function of bone metabolism,improves the levels of estrogen and CT/PTH, reverses the declining tendency of pituitary-thyroid axis function and improves thyroid function so as to weaken osteocyte in the bony absorption, enhance osteoblast in osteogenesis and increase bone density.

AOAP可以通过&多位点相关集合效应&综合调控影响骨代谢的内分泌功能，提高雌激素、降钙素/甲状旁腺素水平，扭转垂体-甲状腺轴功能减退的趋势，改善甲状腺的功能，使破骨细胞的骨吸收减弱，成骨细胞的骨形成增强，增加骨密度。

We have, therefore, investigated the direct effects of adiponectin on primary cultures of osteoblastic and osteoclastic cells in vitro and determined its integrated effects in vivo by characterizing the bone phenotype of adiponectin-deficient mice.

为此，我们研究了脂联素对离体培养的原代成骨细胞和破骨细胞的直接影响，并通过对脂联素缺陷小鼠的骨基因表型的研究明确其在体内的综合作用。

TCP porous ceramics, as a system among bone-defectsrepairing materials, have immeasurable advantage compared with the otherbiomaterials. But at the same time, the preparing process and osteogenetic processof this kind of material are very complicated, and to the material's Ca, Pcomparison and micro-construction is expected extremely high.

TCP多孔陶瓷作为骨替代材料中的一员，有着其它生物医用无机材料无可比拟的优势，但同时，这种材料的制备工艺及在生物体内的降解和成骨过程也比较复杂，材料的Ca、P比例以及微观结构的要求也更高。

The results showed that HGF not influenced the proliferation and osteogenic differentiation of bone marrow-derived mesenchymal stem cells.

结果表明，重组人HGF不影响骨髓间充质干细胞的增殖和向成骨细胞的分化，但可明显促进骨髓间充质干细胞的迁移并抑制anoikis诱导的细胞凋亡；PI-3K和MAPK途径参与了HGF促进细胞迁移的作用。

ABSTRACT Purpose By adding additives in carbonated hydroxyapatite cement to increase its rheology to prepare injectable carbonated hydroxyapatite cement.(1) Test the physicochemistry characteristics of ICHA cement.(2) Evaluate the biocompatibility of ICHA cement.(3) Biomechanieal appreciation of ICHA cement used in distal radius fracture.(4) Study the mechanical stability, degradation and bone formation ability of ICHA cement used in goat lateral tibial plateau compression fracture.

目的 在碳酸化羟基磷灰石(Carbonated hydroxyapatite，CHA)水泥原位固化基础上进行改性研究，通过改变其流变学特性，达到具有良好注射性能的可注射性碳酸化羟基磷灰石(Injectable carbonated hydroxyapatite，ICHA)水泥，为骨科的微创治疗提供新方法：(1)制备ICHA水泥，完成理化性质的检测；(2)进行ICHA水泥的生物相容性评价；(3)探讨ICHA水泥在桡骨远端骨折应用的生物力学固定强度；(4)研究ICHA水泥在实验性大动物胫骨平台压缩性骨折中应用的力学稳定性、降解性能及成骨性能。

The present study has demonstrated the pattern of TNF-α and IL-6 expression, has defined the effect of cellular immunity on BMP-induced osteogenesis at the implant site, and has clarified the immunoregulation by BMP subsequent to bone xenografting, thus opening up a new field of molecular immunology associated with bone xenograft, allowing for the search for a more ideal approach to preventing immune rejection and developing a highly effective xenogenous graft material.

本研究结果揭示了异种骨移植局部TNF-α和IL-6的定位表达及其规律，基本上阐明了移植局部细胞免疫对BMP诱导成骨作用的影响及BMP在异种骨移植局部的免疫调节作用等问题，开辟了异种骨移植分子免疫学新领域，并为选择更理想的移植排斥防治途径和研制高效的异种骨移植材料提供了可靠的实验及理论依据。

It is one of the key pathogeneses of postmenapausal osteoporosis that estrogen deficiency leads to the decrease of OPG、TGFβ expression and the increasing expression of some bone-resorbing cytokines as OPGL、M-CSF and TRAIL, then stimulates osteoclast differentiation and activity, which potentiates bone resorption and bone loss:(2) ICI182780 shows partial transactivating function in osteoblasts, so it should belong to a kind of selective estrogen receptor modulators .

雌激素缺乏可能导致HOB中OPG、TGFβ的表达减少，而解除了对OPGL、M-CSF和TRAIL等刺激OC生成和活化的细胞因子的抑制作用，OC的数量和活性增加，导致骨吸收增强和骨量丢失，这是导致绝经后骨质疏松症的一个重要的发病机制；ICI182780在成骨细胞内表现出促转录活性，因此它并非纯ER拮抗剂，而应属于选择性雌激素受体调节剂(selective estrogen receptor modulator，SERM)。

Plunder melds and run with this jewel!

掠夺melds和运行与此宝石！

My dream is to be a crazy growing tree and extend at the edge between the city and the forest.

此刻，也许正是在通往天国的路上，我体验着这白色的晕旋。