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BACKGROUND: Osteoblasts derived from bone marrow stromal stem cells are the main force of the cells in bone marrow cavity. In the artificial joint replacement cases, their life situation is closely related to conductive pressure of prosthesis.

背景:骨髓基质干细胞来源的成骨细胞是骨髓腔内主要的受力细胞,在人工关节置换病例中,其生命活动状况与假体传导压力有密切关系。

Adipocytes in bone marrow cavity could decrease the activity of ALP, weaken the expression of Collagen Ⅰ mRNA, inhabit osteogenic potential of bone marrow stromal cell, and induce apoptosis of bone marrow stromal cells.

髓内脂肪细胞可降低骨髓基质细胞内ALP活性,减弱CollagenⅠ mRNA表达,干扰其成骨能力,并能诱导骨髓基质细胞发生凋亡,在骨质疏松症的发病中有着重要的意义。

RESULTS: After 3 days of operation, the BMP positive cells were found in the matrix of experimental group I.

将自体成骨样细胞即刻种植在胶原包埋的聚羟基乙酸基质材料上,然后将该复合体或单纯基质材料移植到兔颅骨的一侧全层骨缺损区,作为实验侧或实验侧。

RESULTS: The three kinds of osteotomy in which different levels of osteotomied maxillary complex area were advanced.

通过软硬组织三维有限元模型的建立,可成功模拟面中部牵张成骨术后软组织的变化。

Methods Primary metanephric mesenchyme stem cells were cultivated and multi-directional differentiation was induced.

方法原代分离培养后肾间充质干细胞,在体外特定诱导条件下观察细胞向成骨细胞、脂肪细胞及肾小管上皮细胞的分化及其形态演变,采用细胞免疫荧光检测细胞表面特定蛋白的表达变化。

Objective To investigate whether osteoblasts cultured in vitro can form mineralization nodes.

目的 了解体外培养成骨细胞的接种数量对钙化结节形成的影响。

Objective To investigate the effect of bone morphogenetic protein on the biological activity of osteoblast of healthy people in vitro.

目的 探讨骨形态发生蛋白(bone morphogenetic protein,BMP)对培养的正常人成骨细胞主要生物学行为的影响。

2Its one of cytology mechanisms of Qiang-gu-bao decoction on preventing and curing diabetes osteoporosis were related with promoting for osteoblastic cell proliferation 、 differentition and mineralization of formation,moreover inhibiting nonenzymic glycation reaction and reducing the formation of AGEs on the early stage, inhibiting the secretion of osseous absorptive cytokine, Consequently, Qiang-gu-bao decoction could inhibited bone resorption and promote for bone formation as well as regulated the bone metabolization.

2强骨宝方直接提取液及糖尿病模型大鼠载药血清均能促进 OB 增殖、分化及矿化成骨作用,并抑制早期糖基化反应,减少 AGEs 的形成,抑制 OB 分泌骨吸收因子,从而达到抑制骨吸收、促进骨形成、调节骨代谢,这可能是强骨宝方防治糖尿病性骨质疏松的细胞学机制之一。

Weeks after operation, the expression of integrin β1 mRNA in OVX PII group was similar to JGG group.

术后24周,预防Ⅱ组成骨细胞的Itgβ1 mRNA 的表达水平与健骨颗粒组相近。

The tibiale cortex and bone cell have increased in examination with microscope. The number and function of osteoblast have increased, ossein was improved, number and function of osteoelast were controls in examination with electron microscope.

透射电镜的观察,则进一步证实了其作用机理可能是增加了成骨细胞的数量和活性,抑制了破骨细胞数量和活性,从而增加了骨形成,减少了骨吸收。

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