成骨的

OBJECTIVE: To observe the osteogenic property of platelet-rich plasma induced human BMSCs in vivo and to explore the feasibility of ectopic osteogenesis of platelet-rich plasma induced human BMSCs and combined coralline hydroxyapatite.

目的：观察富血小板血浆诱导培养人骨髓基质干细胞在体内的成骨特性，探讨采用富血小板血浆诱导培养的人骨髓基质干细胞与珊瑚羟基磷灰石材料体内异位成骨的可行性。

Objective To understand the effects of Erigeron Breviscapus on suture osteogenesis during maxillary protraction in animal models.

目的 观察灯盏花在上颌前牵引动物模型中对骨缝成骨的影响。

The "regulable osteoinduction microcirculation/microenvironment system in vivo" has characteristics as follows: the culture conditions are controlled. For example, the release of a variety of growth factors can be controlled stably and quantitatively at bone defect site. Early nutrition and revascularization in the center of tissue-engineered bone can be effectively solved; some shortcomings resulted from construction of tissue-engineered bone in vivo, including secondary injury, high level technical requirements, and complex operation, can be avoided; vascularization and osteogenesis can be constructed simultaneously; simple safe and efficient operation.

可调控的体内灌注诱导成骨微循环系统具有以下特点：可以控制诱导培养条件，如调控各种生长因子微量稳定的缓控释放；能有效解决大块组织工程骨中心部位的早期营养和血运重建难题；避免了组织工程骨体内构建存在的二次损伤，需要较高的技术条件、操作较为复杂等缺陷；实现血管化与成骨的同步构建；操作简便，安全高效。

DATA SYNTHESIS: Compared with the control group, VEGF can promote osteogenesis, bone formation and remodeling through the effect of VEGF on endochondral ossification and intramembranous ossification.

资料综合：与对照组相比，VEGF能通过对软骨内成骨、膜内成骨的影响促进骨的发生、形成和改建。

The aim of the study was to compare the long-term stability of membranous and endochondral autogenous bone grafts with or without combined application of guided bone regeneration. Twenty-fie, male, 6-month old, albino rats were used in the study.

本研究的目的是为了比较当联合应用或不联合应用引导性骨再生技术时，膜形成骨及软骨内成骨的自体骨移植的长期稳定性有无不同。

In my study, a three-dimensional finite element model of human cranial-maxillary complex osteodistraction was established. The stress distribution and displacement under different loads were evaluated. The experiment results were feasible and effective to the stress analysis in the process of orthodontic and orthognathic treatment.

本实验通过建立颅上颌复合体三维有限元模型，分析上颌骨LeFort Ⅰ型截骨后牵张成骨的生物力学特性，明确在不同牵引方向时上颌骨复合体各部位的应力分布特点及位移趋势，为临床改良和优化颅面部牵张成骨的治疗方案提供一定的参考依据。

Objective To investigate the effect of Simvastatin on function of osteoblastic cell differentiation of human bone marrow stromal cells in vitro, and to study the mechanisms of anabolic effect of Simvastatin on bone formation.

目的 观察辛伐他汀对体外培养的人骨髓基质干细胞(Human Bone Marrow Stromal cells， hBMCs)成骨分化功能的影响，探讨其刺激成骨的作用机制。

However, whether the human fibroblasts behave in a similar way has not been reported to our knowledge. In the present study fibroblasts collected from human foreskin were cultured in vitro so as to investigate into the fibro blastic osteogenetic role as well as its mechanism.

本实验包括四个部分：1、人皮肤成纤维细胞体外培养成骨的实验研究。2、猪骨形态形成蛋白（pBMP的提取及生物活性测定。3、pBMP对成纤维细胞成骨影响的实验研究。4、成纤维细胞体外培养过程中骨钙素变化。

Objective: The purpose of this study is to establish a periosteal distraction model on rabbit mandiblar ramus, to observe the formation of newly formed bone and its structure in each phase after distraction of periostea, to observe the changes of periostea after being secondary to distraction forces, to investigate the possibility of osteogenesis by periosteal distraction in oral and maxillofacial region, and to study the possibility of a new restoration method of clincal alveolar and other bony defect.

目的：本研究在兔下颌升支建立骨膜牵张成骨模型，观察牵张骨膜后，在骨膜下新骨的形成，以及新骨在各个阶段的结构，同时观察了骨膜受到牵张力后的改变，研究骨膜牵张在口腔颌面部成骨的可能，为牙槽骨缺损及其他口腔颌面部骨组织缺损探讨新的重建方法。

The periostea of both experimental and control side of the mandibular ramus were taken and prepared, 2 of each 5 rabbits in a group were prepared for HE stain detection and 3 for proliferating cell nuclear antigen immunohistochemical detection.Results:1, The newly formed bone was detected on the lateral aspect of mandibular ramus after periosteal distraction. The bone was shaped like a hill. It looked very low and was full of holes at postoperative day 28. With the time of consolidation period lengthened, the newly formed bone matured gradually. X-ray examination showed the new bone shaped like a hill. The average values of new bone height at postoperative days 28,35,42 and 56 were 1.86 + 0.15mm, 2.29 + 0.29mm,3.19 + 0.13mm and 4.70 + 0.45mm. Histological examination of both HE stain and picricacid-fuchsin stain showed the increase in the number of osteoblasts and the change in the orientation of collagen fibers and bone trabecula. There were no significant differences between newly formed bone and original bone on the lateral aspect of mandibular ramus at postoperative day 56 histologically.2 Compared with the control side, the distracted periostea proliferated obviously under the microscope, and the number of periostealcells increased with satiation of cellular nuclear per unit area. The images of PCNA immunohistochemical stain of periosteum showed that the experimental periosteum proliferated obviously after distraction compared with the control side.

结果：骨膜牵张成骨的实验研究南京医科大学硕{学位论文l、骨膜牵张后，可见下领升支外侧的骨皮质上有新骨形成，新骨呈山峰状凸起，术后第28天的新生骨较低平，多孔隙，随着固定时间的延长，新骨逐渐成熟；下领升支前后向切线位X线投照显示新骨呈山峰样隆起；经测量，术后第28、35、42和56天组平均新生骨厚度分别为x.86士0.15mm、2.29士0.29mm、3.19士0.13mm和4.70 土0.45mm；脱钙骨组织的HE染色和不脱钙骨组织的苦味酸一品红染色的组织学观察均显示了新生骨在成骨细胞数量上的增长，以及胶原纤维和骨小梁排列方向上的变化，术后第56天的新生骨在组织学上与原升支骨组织已无明显区别。2、HE染色显示，与对照组相比较，实验侧骨膜增生明显，细胞间排列紧密，单位面积内骨膜细胞数增多，细胞核饱满；骨膜PCNA 免疫组化染色显示，与对照侧相比较，实验侧骨膜在牵张后出现了明显的增生迹象，PCNA阳性细胞分布紧密，单位面积内阳性细胞数较对照组多，靠近骨表面的骨膜中的阳性细胞数更多而且分布更为紧密。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。