成骨

Although Albee also described the use of calcium phosphates as an alternative to bone in the 1920s, it was not until 1965, when Marshall Urist identified "bone formation by autoinduction"2, that new options unfolded.

尽管Albee也曾在1920年代提出过使用硫酸钙作为骨的替代品，但直到1965年Marshall Urist确定了&自身诱导的成骨&，新的选择展现在了我们的面前。23年后Wozney小组及Luyten小组发现了引起这一现象的蛋白BMPs-2、 3和4。

Lane[1] and Sandhu introduced internal fixation; Albee[2] and Kushner, Henderson[3], Campbell[4], and others added osteogenesis to this principle to deelop bone grafting for nonunion into a practical procedure.

Lane和Sandhu[1]介绍了内固定方法；Albee[2] 和 Kushner、Henderson[3]、 Campbell[4]等人将成骨的概念引入植骨的原理中，使骨移植治疗骨不连成为一种实用的手术。

Although Albee also described the use of calcium phosphates as an alternatie to bone in the 1920s, it was not until 1965, when Marshall Urist identified "bone formation by autoinduction"2, that new options unfolded.

尽管Albee也曾在1920年代提出过使用硫酸钙作为骨的替代品，但直到1965年Marshall Urist确定了&自身诱导的成骨&，新的选择展现在了我们的面前。23年后Wozney小组及Luyten小组发现了引起这一现象的蛋白BMPs-2、 3和4。

METHODS: From January 2000 to May 2002, 52 cases with various types of bone defect were treated with tissue engineered bone, which was constructed in vitro by allogeneous osteoblasts from periosteum 1 x 10(6/ml with bio-derived bone scaffold following 3 to 7 days co-culture. Among them, there were 7 cases of bone cyst, 22 cases of non-union or malunion of old fracture, 15 cases of fresh comminuted fracture of bone defect, 4 cases of spinal fracture and posterior route spinal fusion, 3 cases of bone implant of alveolar bone, 1 case of fusion of tarsotarsal joint.

2000年1月～ 2002年1月，用同种异体骨膜来源的成骨细胞 1×106 / ml与生物衍生骨支架材料构建的组织工程骨，经体外培养 3～ 7天后，植入修复52例各种类型的骨缺损，其中骨囊性病变7例，陈旧性骨折不愈合或畸形愈合 2 2例，新鲜粉碎性骨折伴骨缺损 15例，脊柱骨折后路植骨融合术4例，牙槽骨植骨 3例，足跗中关节植骨融合 1例。

The results show that the hydrophilicity of PLA film is improved by introduction amido: the contact angle decreases from 78° to 56° and the free energy increases from 42.7mJ/m^2 to 51.4mJ/m^2. Compared with the control, osteoblast spread out more filopodia after 3 d incubation on amidation surface, and it entered cell division phase more quickly, which indicated that the surface amidation could promote the cell's adhesion and proliferation on the PLA film.

结果表明，酰胺基的引入改善了PLA膜的表面亲水性，其表面水接触角由78°减少到56°，自由能由42.7mJ/平方公尺增大到51.4mJ/平方公尺；与对照组相比，成骨细胞在改性表面培养3d后有大量的丝状伪足伸出，并且较快地进入了细胞分裂期，表明PLA膜表面的酰胺化能够促进细胞的黏附和增殖。

Objective This study is to investigate the expression of VEGF after exposure of human osteoblasts to anoxic stimuli .

目的 探讨缺氧对人成骨细胞 VEGF表达的影响。

A certain concentration of the antituberculosis drugs could decrease the quantity and activity of osteoblast.

结果：1。高浓度抗结核药物对成骨细胞的数量和功能具有抑制作用；2。

Only nine aspartic acid substitution in type I collagen has been fully reported in the world.

甘氨酸转变成天冬氨酸的这种突变对成骨不全表型具有重要的影响。

There were no cells on the SIS as control. They were implanted subcutaneously in the dorsa of the athymic mice. The implants were harvested after in vivo incubation for 4, 8 and 12 weeks.

将复合培养细胞与单纯材料分别植入无胸腺裸鼠皮下，扫描和透射电镜观察植入前和植入后4、8、12周成骨细胞、血管生成的变化过程。

Objective To observe the effects of the fracture-healing stimulin, a fracture healing increaseing drug from staphylococcus aurous on osteoblasts in vitro.

目的 观察骨折愈合刺激素对体外培养成骨细胞的作用。

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。