成纤维细胞的

Proliferation of fibroblastic cells in bone marrow,caus in g anemia and sometimes enlargement of the spleen and liver.

骨髓纤维化，骨髓纤维变性在骨髓中成纤维细胞的扩散，常引起贫血症，而且有时也会导致脾和肝的增大

Expression of hepatocyte markers such as ALB and CK18 was measured with immunohistochemistry. RESULTS: Cells in control group kept the long spindle shape, with shape agent as 4.5±1.0 and small size, proliferated quickly, submitted typical fibroblast whirlpool or flamboyancy growth. Five to seven branches were observed at the late culture period, no cell rounded, and the rate of dikaryocyte was less than 0.1%.

结果：未进行诱导的对照组细胞保持长梭型，形状因子4.5±1.0，面积较小，增生较快，呈典型成纤维细胞的漩涡状或火焰状生长，培养后期可见5~7个分支，无细胞变圆，双核细胞率小于0.1%，逐渐老化，颗粒增多。

Aminoglycosides suppress termination at nonsense codons and result in functional improvement in a cystic fibrosis bronchial epithelial cell line, in muscle cells from mdx mice and in fibroblasts from individuals with Hurler syndrome.

氨基糖苷类物质可以通过抑制无意义密码子的终止作用，改善囊性纤维化的支气管上皮细胞、患肌营养不良的肌细胞和Hurler综合征病人的成纤维细胞的功能。

Methods 12 guinea pigs of 20 months with 3 cm×3 cm hair sheared from their backs were divided into control group and experimental group. Rhodosin and deer serum preparation was besmeared on the skin of guinea pigs in experimental group, and cosmetic matrix was besmeared on the skin of animals in control group for 60 d. The distribution of type Ⅲ collagen was observed with Sirius red staining and HE staining. The fission index of the cells of stratum basale, the thickness proportion of stratum corneum to epidermis, the volume density of the collagen fibers and small blood vessel in dermis, the number of fibroblasts in aging skin were meassured with technique of sterology.

背部被剪去3 cm×3 cm毛的12只20月龄豚鼠被随机均分为给药组和对照组，给药组涂抹红鹿制剂，对照组涂抹化妆品基质，连续涂抹60 d；应用天狼猩红、HE染色和体视学技术分别观察和测定老化皮肤中Ⅲ型胶原的分布、表皮基底层细胞的分裂指数、角质层同表皮厚度的比例、真皮胶原纤维和微血管的体密度和成纤维细胞的数目。

We hypothesized that MCP-1 may mediate fibrotic remodeling through recruitment of mononuclear cells and direct effects on fibroblasts.

我们假设MCP-1 可能通过单核细胞的复原和成纤维细胞的影响造成间接的纤维化重构。

Finally, we established rat model of PF induced by bleomycetin, and observed the interventional action of phenol total base to model. The analysis of experimental result including pathematologic and tissue biochemical indicator showed phenol total base of plumula nelumbinis have some therapeutic action to rat model of PF induced by BLM.

通过病理学观测及组织生化指标的检测(SOD、MAD、GSH一PX、Hyp)，说明莲子心酚性总碱对博莱霉素致大鼠肺纤维化有一定治疗作用，可能的作用机制：降低肺纤维时胶原含量；抑制肺成纤维细胞的增殖；抗自由基和抗脂质过氧化作用及提高了机体内GSH一Px含量。

The mechanism of action maybe include the depression in content of collagen, inhibition to proliferation of lung fibroblast, action of anti free redical and anti lipid peroxidation, and elevation of content of GSH-PX.So we think phenol total base of plumula nelumbinis is a sort of promising drug to healing PF.

综上所述，我们认为莲子心酚性总碱可能对肺纤维化的病理过程有多靶点作用：前期通过抗自由基作用，从而减轻肺泡炎损伤：后期直接抑制肺成纤维细胞的增殖及蛋白沉积，减轻纤维化病变程度。

Cell proliferation was measured with cell number,cell metabolic activity (WST-1 cleavage),DNA synthesis and cell cycle assayed with flow cytometry.

进行新西兰白兔心脏心肌成纤维细胞的培养；测定细胞计数，细胞活性（WST－1分解）和DNA合成，并以流式细胞仪测定细胞周期等以表示细胞增殖。

Methods: Cardiac myofibroblasts derived from heart of New Zealand rabbit were cultured and identified. Cell proliferation was measured with cell number,cell metabolic activity (WST-1 cleavage),DNA synthesis and cell cycle assayed with flow cytometry.

进行新西兰白兔心脏心肌成纤维细胞的培养；测定细胞计数，细胞活性（WST－1分解）和DNA合成，并以流式细胞仪测定细胞周期等以表示细胞增殖。

METHODS: We assessed the number of fibrocytes in bronchial biopsy specimens and peripheral blood from subjects with mild-to-severe refractory asthma versus healthy control subjects.

我们评估了轻－重度难治性哮喘患者气道活检标本和外周血中成纤维细胞的数量，同时通过体外实验，探讨了调控纤维细胞向气道平滑肌移行的可能机制。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新