成牙骨质细胞

Apoptosis of HERS cells may be the signal of cementum development, and some HERS cells may be directly participate in the progress.

HERS细胞的凋亡可能会为成牙骨质细胞分化提供信号，部分HERS细胞可能参与牙骨质的形成。

RESULTS: BMP-2 was mainly found in the plasma of fibroblast, osteoblast, cementocyte, odontoblast separately.

结果：牙周膜成纤维细胞、成骨细胞、成牙骨质细胞及胶原纤维中均可见BMP-2阳性染色。

He effect of antibiotics in inducing the formation of apices is to prevent infection of root canal, rather than direct induction. And TGF-β1 might act as an inductive factor in the cell differentiation of the above-mentioned cells.

GF-β1参与了尖周组织的修复过程，可能诱导了成牙本质样细胞、成牙骨质样细胞和骨样细胞的分化，在牙根继续形成中起着重要作用。

On the other hand, extract of cemental matrix was separated and clarified from healthy teeth which were extracted because of orthodontic treatment.

从因正畸需拔除的健康牙体表面获得牙骨质基质提取物，分别观察不同作用时间、不同浓度的牙骨质基质提取物对牙龈成纤维细胞和牙周膜成纤维细胞在牙体表面附着的影响。

Results: The extract of cemental matrix could enhance the initial attachment of human gingival fibroblasts and human periodontal cells to the surface of root, and such effects were strengthened with increasing density and time.

且牙骨质基质提取物促牙周膜成纤维细胞附着的作用高于对牙龈成纤维细胞的作用。

The pathogenesis of root resorption is still not clear. Cementoblast plays a central role in repair root resorption by synthesizing cementum matrix.

成牙骨质细胞是牙骨质的功能细胞，在牙根形成、牙周病牙骨质的再生以及正畸相关炎性牙根吸收的修复中起着重要的作用。

Conclusions】 EMPs and BMP-2 have the ability to induce HDFCs to differentiate toward an osteoblast or cementoblast phenotype.

EMPs、BMP-2可使牙囊细胞表型向成骨、成牙骨质样细胞分化。

During the development of dental germ, enamel matrix proteins secreted by epithelial root sheath could induce dental follicle cells to differentiate towards cementoblast and form acellular cementum finally on the surface of tooth root. Many researches of domestic and oversea scholars suggest that enamel matrix proteins could effectively induce periodontal regeneration, and the structure and function of this regenerated tissue are similar to healthy periodontal tissue. Moreover, the regeneration process is nearly the same to that of embryonic development of periodontal tissue.

自发现釉基质蛋白可诱使牙囊细胞向成牙骨质细胞方向分化并在根表面形成无细胞性牙骨质以来，国内外学者做了大量研究，结果表明釉基质蛋白能有效诱导牙周组织的再生，且这种再生组织的结构和功能更接近于健康的牙周组织，并且再生过程也与牙周组织的胚胎发育过程类似。

RESULTS: During tooth root patterning, expression of MSX1 was found not only in dental papilla of the apical area, dental sac and odontoblasts, but also in dental attachment apparatus such as cementoblast, periodontal supporting tissues and alveolar bone.

结果：在牙根发育不同时期内，MSX1mRNA不仅在牙乳头、牙囊组织及成牙本质细胞中有阳性表达，而且在牙附着组织，如成牙骨质细胞、上皮根鞘、牙周组织及根周牙槽骨组织中也有表达。

However, it is not known how orthodontic force influences the function of cementoblast and what is the relationship between the function change of cementoblast with root resorption. So we studied the effect of mechanical stimuli on root resoption by examining the expression OPG and RANKL and exploring the related signal transduction pathway in cementoblast. Methods: Cementoblasts OCCM30 were cultured in DMEM with 10% FBS for 48 hours and starved in DMEM with no FBS for 24 hours, then subjected to mechanical strain by four-point bending system with tension and compression stress at 2000μstrain at 0.5Hz frequency. The flow cytometry was used to examine the cell cycle and proliferation activity after 3h, 6h, 12h, 24h loading respectively. OPG and RANKL mRNA were analysed with real time quantitive RT-PCR after the same loading period as FCM.

本课题利用四点弯曲力学加载系统，采用流式细胞术、实时荧光定量PCR、Western免疫印迹等方法，研究体外培养的成牙骨质细胞株OCCM-30在不同力学环境中增殖活性的变化，以及其表达骨保护素和破骨细胞分化因子的mRNA的变化，探讨应力刺激对成牙骨质细胞表达破骨细胞分化调控蛋白的影响，并通过对应力刺激下成牙骨质细胞分裂原活化蛋白激酶家族中的ERK1/2、P38MAPK活性的变化及其与OPG、RANKL基因表达变化关系的研究，对力学刺激调节破骨细胞分化调控蛋白的相关上游信号转导通路进行初步探讨。

It has been put forward that there exists single Ball point and double Ball points on the symmetrical connecting-rod curves of equilateral mechanisms.

从鲍尔点的形成原理出发，分析对称连杆曲线上鲍尔点的产生条件，提出等边机构的对称连杆曲线上有单鲍尔点和双鲍尔点。

The factory affiliated to the Group primarily manufactures multiple-purpose pincers, baking kits, knives, scissors, kitchenware, gardening tools and beauty care kits as well as other hardware tools, the annual production value of which reaches US$ 30 million dollars.

集团所属工厂主要生产多用钳、烤具、刀具、剪刀、厨具、花园工具、美容套等五金产品，年生产总值3000万美元，产品价廉物美、选料上乘、质量保证，深受国内外客户的青睐