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戊胺

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Using pentaerythritol as initiator, boron trifluoride diethyl etherate as catalyst.dichloroethane as dispersion agent, the chloride polyether polyol is synthesized based on the mechanism of cationic ring-opening polymerization of epiclilnrohyclrin.The azide polyether polyol is synthesized, in DMF through A and sodium azide, and the non-reported azide energetic curing agent is synthesized through the adduction of B and IIDI.

以季戊四醇为起始剂,三氟化硼乙醚为催化剂,1,2—二氯乙烷为分散剂,环氧氯丙烷经阳离子开环聚合反应制成氯化聚醚多元醇,A在N,N—二甲基甲酰胺中与叠氮化钠反应制得叠氮聚醚多元醇,B与六亚甲基二异氰酸酯加成反应制得未见文献报道的叠氮固化剂。

The extremities were titanic, and there was no response to touch stimulations.Our results suggested that Pentobarbital sodium inhibited neuronal firing through GABA_A receptors, therefore the local field potentials and neural firing rates were inhibited; Urethane acted on many kinds of receptors including inhibitory and excitory ones, so the local field potentials did not change significantly; however, because of the multiform receptors on the neurons, the changing of firing rates to different neurons were not the same; Ketamine mainly acted on the NMDA receptors, therefore the local field potentials and neural firing rates were enhanced, and most neural firing rates would be increased.

从这三种麻醉剂的底层作用机制来看,戊巴比妥钠通过作用于GABAA受体对神经细胞发挥抑制性作用,因此表现为场电位和神经元放电的降低;氨基甲酸乙酯同时作用于多种受体通道,既有兴奋性受体,也有抑制性受体,因此,对场电位的影响不大,但对单个神经元来说,每个神经细胞上的受体通道分布差异较大,因此,单个神经元的放电频率变化会有所不同;盐酸氯胺酮主要作用于兴奋性的NMDA受体,故整体场电位活性增加,多数神经元的放电频率也会有所升高。

The main research now is focused on the polymerization of difluoramino substituted oxetane monomers, the preparation of neopentyl difluoramino nitrato plasticizers, and the molecular design and synthesis of cyclic N2 nitramino geminal difluoramino oxidizers.

目前该领域的研究工作主要集中在二氟氨基取代环氧丁烷聚合物合成,新戊基二氟氨基硝酸酯增塑剂制备,以及环N2硝胺基偕二氟氨基氧化剂的分子设计与合成上。

METHODS: In fed rats, the effects of pentobarbital,isoflurane, sevoflurane, ketamine-medetomidine-atropine, and sufentanil-propofol-morphine on the cardiaccellular localization of hexokinase and levels of plasmaglucose and insulin were determined and compared with valuesobtained in nonanesthetized animals.

测定戊巴比妥、异氟烷、七氟烷、氯胺酮-美托咪定-阿托品和苏芬太尼-丙泊酚-吗啡麻醉下人工饲养大鼠心肌细胞己糖激酶定位和血浆葡萄糖及胰岛素浓度,并将之与未麻醉大鼠的对应参数作对比。

All dates were analyzed by the principal component analysis through using the SIMCA-P 10.0 software. Result: The PCA demonstrated that the metabolome between treated group and control group had difference in rat urine sample after of 22 days administrated, for treated group 169 kinds of biomarkers were found including oxalacetic acid, malic acid, 2-ketoglutaric acid, NE, arachidonic acid, 5-HIAA and other compounds, the result was consistent with pharmacological effects of R.coptidis , such as antiinflammatory, inhibiting biosynthesis of CA biosynthesis, anti-central nerve and energy metabolism inhibition.

结果:给药22 d,黄连组与对照组大鼠尿样代谢组有较大差异,发现了169个生物标记物,其中可能的化合物为草酰乙酸、苹果酸、2-酮戊二酸、去甲肾上腺素、花生四烯酸、5-羟吲哚乙酸等物质,这与黄连抗炎、阻止儿茶酚胺的生物合成、抑制中枢神经、降低能量代谢的药理作用相一致。

Adopting intumescent flame retardant that uses ammonium phosphate as acid source, melamine as gas source, pentaerythrite as carbon source to treat cotton fabric.

采用聚磷酸按为酸源、三聚氰胺为气源、季戊四醇为碳源的膨胀型阻燃剂对棉织物进行整理。

Polyethylene glycol ethers of alkyl alcohols having the general formula CH3(CH2)xCH2(OCH2CH2)nOH wherein x is 8 to 20 (of which ceteareth-20, steareth-20 and steareth-100 are preferred), poloxamer 185, poloxamer 407, N,N-dimethyl dodecylamine N-oxide, and mixtures thereof, are employed to increase follicular delivery and/or follicular residence time of certain water soluble ornithine decarboxylase inhibitors of which 2-2,5-diamino pentanoic acid and its pharmaceutically acceptable salts, hydrates, optical enantiomers and racemic mixture are preferred.

使用通式为CH3(CH2)xCH2(OCH2CH2)nOH的烷基醇的聚乙二醇醚,其中x为8-20(其中鲸蜡硬脂醇醚-20、硬脂醇醚-20和硬脂醇醚-100是优选的)、poloxamer 185、poloxamer 407、N,N-二甲基十二烷胺N-氧化物及其混合物来提高某些水溶性的鸟氨酸脱羧酶抑制剂的毛囊传输和/或毛囊停留时间,优选的抑制剂是2--2,5-二氨基戊酸及其药学上可接受的盐、水合物、光学对映异构体及外消旋混合物。

One of these compounds, 2-diethyl- aminoethyl-5--(4-methoxybenzylidene) cyclo- pentanone hydrochloride (T81) possessed sig- nificant antiinflammatory and analgesic ac- tivity when administered orally.

Ⅲ类化合物完全无抗癌活性,对其中一个化合物2-二乙胺乙基-5--(4-甲氧基苯亚甲基)环戊酮盐酸盐(T81)试验结果表明,它经口给药时具有显著的抗炎、镇痛活性。

The lignin-quaternary/polyvinyl alcohol composite resin was made from lignin after phenolization and amination,using glutaraldehyde as cross-linking agent,PVA as carrier.

利用木质素为原料,经酚化、胺化改性后,以戊二醛为交联剂,聚乙烯醇为载体,合成了季铵型木质素/PVA复合阴离子交换树脂。

Diaminoalkanes react with sym - tetrachloroethane to give crystaline 2,2'- Bis -( hexahydropy-rimidine) derivatives 1 - 5, after treatment with aqua ammonia.

利用均四氯乙烷及二氯甲烷的胺化反应,合成了联氢化嘧啶衍生物1~5,4a,8b-反-4,5,8a,9a-四氮杂全氢芴(6)和8b,8c-顺-3a,4a,7a,8a-四氮杂环戊并全氢芴(7)。

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