戊巴比妥钠

METHOD: The following tests were made:①test with of hemopoietic inhibition induced by cyclophosphamide on mice,②Carban particles clearance test,③Erythrolysin formetien test,④Swimming test,⑤Hypoxia test,⑥Sedation test,⑦Hypnosis test.

①由环磷酸胺引起的小鼠造血系统抑制模型；②小鼠碳粒廓清试验；③小鼠溶血素形成试验；④小鼠游泳试验；⑤小鼠耐缺氧试验；⑥小鼠旷野活动试验；⑦由戊巴比妥钠引起的小鼠催眠模型。

The extremities were titanic, and there was no response to touch stimulations.Our results suggested that Pentobarbital sodium inhibited neuronal firing through GABA_A receptors, therefore the local field potentials and neural firing rates were inhibited; Urethane acted on many kinds of receptors including inhibitory and excitory ones, so the local field potentials did not change significantly; however, because of the multiform receptors on the neurons, the changing of firing rates to different neurons were not the same; Ketamine mainly acted on the NMDA receptors, therefore the local field potentials and neural firing rates were enhanced, and most neural firing rates would be increased.

从这三种麻醉剂的底层作用机制来看，戊巴比妥钠通过作用于GABAA受体对神经细胞发挥抑制性作用，因此表现为场电位和神经元放电的降低；氨基甲酸乙酯同时作用于多种受体通道，既有兴奋性受体，也有抑制性受体，因此，对场电位的影响不大，但对单个神经元来说，每个神经细胞上的受体通道分布差异较大，因此，单个神经元的放电频率变化会有所不同；盐酸氯胺酮主要作用于兴奋性的NMDA受体，故整体场电位活性增加，多数神经元的放电频率也会有所升高。

GroupⅤwas perfused with pentobarbital sodium and nikethamide(5mmol/L).

I组用Kreb氏液洗脱，Ⅱ-Ⅴ组用戊巴比妥钠Kreb氏液洗脱。

Methods The effects of Wuweizi Ningshen Oral Liquid on sedation,hypnotics and anti-convulsion in mice were observed by counting spontaneous behavior,prolonging sleeping time cooperated with pentobarbital sodium and antagonizing convulsion induced by Nikethamide injection.

采用镇静、催眠、抗惊厥实验观察五味子宁神口服液对小鼠自主活动的影响，协同戊巴比妥钠对小鼠的催眠作用及对小鼠尼可刹米惊厥的抑制作用。

MethodsThe effects of Wuweizi Ningshen Oral Liquid on sedation,hypnotics and anti-convulsion in mice were observed by counting spontaneous behavior,prolonging sleeping time cooperated with pentobarbital sodium and antagonizing convulsion induced by Nikethamide injection.

方法采用镇静、催眠、抗惊厥实验观察五味子宁神口服液对小鼠自主活动的影响，协同戊巴比妥钠对小鼠的催眠作用及对小鼠尼可刹米惊厥的抑制作用。

Results:It is suggested that the drug significantly protectes liver from CCl4,thioacetamide and galactosamine in mice and rats,lowers the activity of enzyme ALT in serum,shorten the sleep duration of CCl4-damaged mice induced by embuter,inhibites HBsAg in vitro,and potentiates non-specific immunity in mice and rats.

结果：研究表明，该药对四氯化碳、硫代乙酰胺和氨基半乳糖引起小鼠及大鼠的急性肝损伤有明显的保护作用，能降低谷丙转氨酶；缩短CCl4肝损伤小鼠戊巴比妥钠的睡眠时间；抑制体外乙肝病毒表面抗原；对非特异性免疫有一定增强作用。

Blood pressurewere recorded and blood were drawn from inferior vena cava and kidneys, adrenals were removed.

第8周末，大鼠在戊巴比妥钠麻醉下，直接测量颈总动脉血压，开腹抽取下腔静脉血及剖取肾脏、肾上腺。

When we begin to the medicine, urine protein was measured in urine volume of 24 hour the every two day. 4. Specimen collections and laboratory check: In the 21 days of pregnant rats, infants were taken which registered weight and height after aesthesia. Cr and BUN in the blood were measured.

标本收集和实验室检查：于妊娠第21天在戊巴比妥钠(50mg/kg)麻醉下，剖宫取胎，记录胎仔体重，身长；同时抽取腹腔静脉血，分离血清以待测定血尿素氮，血肌酐；取左肾部分置于10%甲醛液浸泡固定，待用HE染色、PAS染色及免疫组织化学染色；另取部分肾脏剪成体积约1cm〓大小组织块，生理盐水冲洗至发白，-70℃保存。

Rats in the group R and group M were exposed to thoracic radiation at a dose of 20 Gy by linear accelerator after intrabdminal injection pentobarbital Sodium by 40 mg/kg.

照射组和治疗组腹腔内注射戊巴比妥钠40 mg/kg给予直线加速器照射，照射剂量单次20 Gy/min，照射前7 d，照射组给予等量生理盐水腹腔内注射，治疗组给予氨溴索35 mg/kg。

On pentobarbital anesthetized rabbits, a three-wavelet compound potential to cervical vagal afferent stimulation was recorded in ipsilateral nucleus tractus solitarius.

在戊巴比妥钠麻醉兔，电刺激颈迷走神经中枢端，在同侧孤束核区可记录到一个由三个子波组成的复合电位。

Shop assistant: Please check at the door.

店员：请您到门口柜台交费。

In the end, transportation of PAHs in the environmental matrix was preliminarily investigated and discussed according to PAHs data of soils and sediments from a certain region in Shanghai. The result indicated that there are two or more pathways on PAHs transportation in the environmental matrix.

最后，对上海特定地区内PAHs在环境介质中的迁移径途进行了分析讨论，结果表明上海市土壤和沉积物等环境介质中PAHs的迁移存在多种途径。