戊巴比妥钠

ResultsThe Ziziphus jujube leaf extract could inhibit autonomic activities of the mice, prolong the sleep time induced by pentobarbital sodium, enhance the rate of falling asleep induced by barbital sodium and inhibit the central stimulating effects induced by amphetamine.

结果酸枣叶提取物可对小鼠自主活动呈明显抑制作用，延长戊巴比妥钠诱导的小鼠睡眠时间，增加巴比妥钠诱导的小鼠睡眠发生率和缩短巴比妥钠诱导的小鼠睡眠潜伏期。抑制苯丙胺的中枢兴奋作用。

The effect of sleep improvement of the three dosages(570 mg/kg,1000 mg/kg and 2000 mg/kg)of Semen Ziziphi Spinosae was studied by the experiments of sleep-induced directly, prolonging sleeping time induced by pentobarbital sodium, affecting mouse sleeping rate under the threshold hypnogenesis dosage of pentobarbital sodium and affecting sleeping delitescence induced by tobarbital sodium. The content of 5-HT in the brain of mouse was measured by fluorescence assay.

通过直接睡眠实验、延长戊巴比妥钠睡眠时间实验、戊巴比妥钠阈下催眠剂量实验和巴比妥钠睡眠潜伏期实验，比较低、中、高3个剂量（570 ，1 000 及2 000 mg/kg）酸枣仁粉剂对小鼠睡眠的影响，并且用荧光法测定小鼠脑中 5-羟色胺含量。

Results The result showed that 0.7% and 1% sodium pentobarbital anesthesia duration was too short, 1.5% pentobarbital sodium easily made animal deaths, and 10% chloral hydrate used for anesthesia in mice was appropriate. And the glass cannula was more suitable than adhesive bandages for enswathement.

结果 0.7%和1%戊巴比妥钠麻醉持续时间过短，1.5%戊巴比妥钠和10%水合氯醛能维持足够手术操作所需的时间，但1.5%戊巴比妥钠易导致动物死亡，故采用10%水合氯醛麻醉小鼠较合适；玻璃套管法包扎的效果较创可贴法为好且更简便。

MethodsIts effect on sleep was observed through the experiments of sleep induced directly,prolonging sleeping time induced by pentobarbital sodium,affecting sleeping rate under the threshold hypnogenesis dosage of pentobarbital sodium,shortening sleep delitescence induced by tobarbital sodium.

方法通过直接睡眠实验、延长戊巴比妥钠睡眠时间、戊巴比妥钠阈下催眠剂量实验和缩短巴比妥钠睡眠潜伏期实验观察灵芝提取物对睡眠的作用。

Nembutal Sodium exerts a depressant action on the CNS and shares the sedative-hypnotic actions typical of the barbiturates.

戊巴比妥钠对中枢神经系统产生抑制作用，并显示戊巴比妥类特有的镇静催眠作用。

Methods The compound preparation was administered intragastrically in mice, whose spontaneous activity was observed along with their tolerance of the preparation after long-term administration. The hypnotic effect of the compound was assessed by investigating the changes in the pentobarbital sodium-induced sleeping. The compound was tested for its antiseizure effect in mice with pentetrazole-induced clonic and tonic convulsion. Diazepam was used as the standard control in all experiments.

利用光电计数法观察灌胃给予复方酸枣仁油栀子油对小鼠自发活动的影响，以及长期使用药物对小鼠耐受性的影响；利用延长戊巴比妥钠睡眠时间实验和戊巴比妥钠阈下催眠剂量实验，观察复方酸枣仁油栀子油的催眠作用；利用戊四氮诱发小鼠阵挛性、强直性惊厥观察复方酸枣仁油栀子油的抗惊厥作用；本实验用地西泮进行平行对照实验，并进行了组方设计和实验。

In groups B1, B2 and B3 , after 10 minutes of injecting the additional dose of pentobarbital sodium, pentoxifyllinel in doses of 60mg/kg, 30mg/kg and 15mg/kg were injected respectively. In group C, 125mg/kg of nikethamide was injected after 10 minutes of injecting the additional dose of pentobarbital sodium.

在B1、B2、B3 三组家兔，于再注戊巴比妥钠后(即加注15 mg/kg戊巴比妥钠后)10 分钟，按等比级数分别注射60mg/kg、30mg/kg、15mg/kg 剂量的己酮可可碱；在C 组家兔则注射尼可刹米125 mg/kg 作阳性对照药物。

In comparison with the control group, the time to falling asleep and the duration of sleep due to supraliminal dosage of sodium pentobarbital were shortened and prolonged significantly, respectively,in the small-dosage and large-dosage groups.

橙皮水提取物小剂量给药组，大剂量给药组能显著加速阈上剂量戊巴比妥钠的入睡时间和延长戊巴比妥钠的睡眠时间，差异有显著性意义。

Methods After taking triazolam and distilled water respectively, the mice sleeping-behavior state was observed and recorded; the ratio of sleeping mice was recorded after taking different of ingredients Eucommia ulmoides Oliv. combining with pentobarbital sodium at subliminal dose, and mice latent period and sleeping time at supraliminal dose. Measure the content of interleukin-1β(IL-1β) in mice brain with enzyme-linked immunosorbent assay, weigh spleen and thymus of mice.

通过观察记录日间小鼠睡眠行为状态，戊巴比妥钠阈下催眠剂量实验，延长戊巴比妥钠睡眠时间实验，酶联免疫吸附反应分别检测服用3种不同极性的提取部位、阳性对照物和空白对照组的小鼠脑组织中IL-1β含量，并结合脏器指数等综合分析。

ResultsThe Ziziphus jujube leaf extract could inhibit autonomic activities of the mice, prolong the sleep time induced by pentobarbital sodium, enhance the rate of falling asleep induced by barbital sodium and inhibit the central stimulating effects induced by amphetamine.

结果酸枣叶提取物可对小鼠自主活动呈明显抑制作用，延长戊巴比妥钠诱导的小鼠睡眠时间，增加巴比妥钠诱导的小鼠睡眠发生率和缩短巴比妥钠诱导的小鼠睡眠潜伏期。

Shop assistant: Please check at the door.

店员：请您到门口柜台交费。

In the end, transportation of PAHs in the environmental matrix was preliminarily investigated and discussed according to PAHs data of soils and sediments from a certain region in Shanghai. The result indicated that there are two or more pathways on PAHs transportation in the environmental matrix.

最后，对上海特定地区内PAHs在环境介质中的迁移径途进行了分析讨论，结果表明上海市土壤和沉积物等环境介质中PAHs的迁移存在多种途径。