戊基

The cytotoxicity of these compounds were valuated by MTT and SRB methods using three cancer cell lines: HL-60, A-549, P-388. Cyclo-shikonin, and cyclo-alkannin have high cytotoxicity against HL-60.The chiral center of side chain has no effect on their activity. 2- 1-(Acetyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (105) has strong inhibition effect on P-388 cells. 2- 1-(isooctyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (108) and 2- 1-(2-furoyloxy-4-methyl-3-pentenyl -5, 8-dihydroxy-1, 4-naphthoquinone (112) have high inhibition on A-549.Shikonin (1), alkannin (2), and their derivatives have the structural features of a planar chromophores and short side chain. We examined the ability to inhibit the telomerase.

抗肿瘤活性初步筛选测试采用小鼠白血病P-388肿瘤细胞和人肺癌A-549肿瘤细胞进行，结果表明侧链羟基的手性对抗肿瘤活性无明显影响；有数个化合物具有很好的体外抑制活性，特别是化合物2-（1-异辛酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（108）和2-[1-（2-呋喃甲酰氧基）-4-甲基-3-戊烯基]-5，8-二羟基-1，4-萘醌（112）体外显示对人肺癌A-549肿瘤细胞有强效；2-（1-乙酰氧基-4-甲基-3-戊烯基）-5，8-二羟基-1，4-萘醌（105）对小鼠白血病P-388肿瘤细胞有强效；环紫草素和环异紫草素对人白血病HL-60细胞有强烈抑制作用。

The crosslinked rubber with dicyclopentadienecrosslinkage was prepared by the reaction between the chlorohydrin rubberand the cyclopentadienyl sodium.

以环戊二烯基钠与氯醇橡胶反应，制得了含CPD侧基和双环戊二烯交联的聚合物。

Thus, an aldohexose is a hexose that has an aldehyde group; a ketopentose is a pentose with a ketone group, etc.

因此，己醛糖是带有醛基的己糖；戊酮糖是带有酮基的戊糖，以此类推。

So, by the Diels-Alder reaction of tetraphenylcyclopentadienone, acenaphthenecyclone and benzophenanthrenecyclone with the vinyl groups in C gum, three kinds of polymethylvinylsilicone oil with condensed aromatics are synthesized respectively: polymethylvinylsilicone oil with tetraphenylphenyl groups (called C_1 gum for short), polymethylvinylsilicone oil with acenaphthenyl groups (C_2 gum) and polymethylvinylsilicone oil with benzophenanthrene groups (C3 gum).

根据此原则，利用四苯基环戊二烯酮、苊式环戊二烯酮和菲式环戊二烯酮与C胶上的乙烯基进行Diels—Alder反应，分别合成了三种含稠环基团的乙烯基硅油：四苯基苯基乙烯基硅油(C_1胶)，苊式多苯基苯基乙烯基硅油(C_2胶)和菲式多苯基苯基乙烯基硅油(C_3胶)，并根据~1HNMR谱图上不同氢原子的积分面积计算了三种胶中稠环基团和乙烯基的含量。

Water,caprylic/capric triglyceride,mineral oil,butylene glycol,stearic acid,acetylated lanolin,glycerin,ethylhexyl methoxycinnamate,dimethicone,polyisoprene,triethanolamine,cyclopentasiloxane,butyl methoxydibenzoylmethane,titanium dioxide,persea gratissima oil unsaponifiables,sodium DNA,borago officinalis seed oil,oenothera biennis oil,simmondsia chinensisseed oil,hydrolyzed RNA,tocopheryl acetate,urea,hydrolyzed extensin,retinyl palmitate,sodium hyaluronate,helianthus annuusseed oil,tocopherol,ascorbyl palmitate,ascorbic acid,lanolin alcohol,c12-20 acid peg-8 ester,cyclotetrasiloxane,glyceryl stearate,dimethiconol,ceteareth-20,carbomer,magnesium aluminum silicate,propylene glycol,peg-8,silica,BHT,citric acid,phenoxyethanol,methylparaben,butylparaben,ethylparaben,isobutylparaben,propylparaben,chlorhexidine digluconate

水，辛酸/癸酸三酸甘油酯，矿物油，丁二醇，硬脂酸，乙醯化羊毛脂，甘油，4-甲氧基肉桂酸-2-乙基己基酯，地美司康，聚异戊烯，三乙醇胺，环戊硅氧烷，丁基甲氧基二苯甲醯基甲烷，二氧化钛，酪梨油，DNA 钠盐，琉璃苣種子植物油，月见草油，荷荷巴籽油，水解RNA，醋酸盐维他命E，尿素，水解伸展蛋白，维他命A酯，透明质酸钠，葵花籽油，维生素E，抗坏血酸棕榈酸酯，维生素C衍生物，羊毛脂醇，C12-20 酸 PEG-8酯，环四硅氧烷，甘油硬脂酸，聚二甲基硅氧烷醇，鲸蜡硬脂醇醚-20，卡波姆，硅酸镁铝，丙二醇，聚乙二醇-8，二氧化硅，二丁基羟基甲苯，柠檬酸，苯氧乙醇，羟苯甲酯，羟苯丁酯，羟苯乙酯，羟苯甲酸异丁酯，羟苯丙酯，洗必泰葡萄糖酸盐

However, the first one enzyme 1-deoxy-D-xylulose 5-phosphate synthase gene and the second one enzyme 1-deoxy-D-xylulose 5-phosphate reductoisomerase gene in MEP pathway had been reported and expressed in the latex of rubber tree, indicating that MEP pathway may be involved in rubber biosynthesis.4 - hydroxy -3 - methyl -2 -- butenyl -4 - phosphate reductaseis the last enzyme that catalytic 4 - hydroxy -3 - methyl -(2E)- butenyl -4 - phosphate to generate isopentenyl pyrophosphate.

然而已有报道MEP途径中第1个酶1-脱氧-D-木酮糖-5-磷酸合成酶（1-deoxy-D-xylulose 5-phosphate synthase，DXS）基因和第2个酶1-脱氧-D-木酮糖-5-磷酸还原酶（1-deoxy-D-xylulose 5-phosphate reductoisomerase ，DXR）基因在橡胶树胶乳中的表达，这表明MEP途径可能参与橡胶的生物合成。4-羟基-3-甲基-2--丁烯基-4-磷酸还原酶（4-hydroxy -3-methyl-2--butenyl-4-diphosphate reductase，HDR）是异戊烯基焦磷酸合成途径之一甲基赤藓糖磷酸（methylerythritol phosphate，MEP）途径中的最后一个酶，催化4-羟基-3-甲基-(2E)-丁烯基-4-磷酸生成异戊烯基焦磷酸。

After the supplement of L-Leu, extracellular isovaleric acid was accumulated in vitro and then reabsorbed for eutilization, the ultimate relative content of isovalerylspiramycin II, isovalerylspiramycin III was increased by 41% and 50% respectively, and the relative content of total isovalerylspiramycins increased by 41.9% with the biological titer of biotechspiramycin being equal to that of the control group.

添加Leu对初级代谢影响不大，异戊酸在胞外积累，随后被重新吸收利用，最终异戊酰基螺旋霉素II和异戊酰基螺旋霉素III组分分别提高了41%和50%。同时总异戊酰基螺旋霉素相对含量也比对照提高了41.9%，效价和对照基本一致。

These compounds were identified as follows:chrysophanol (FP-1),physcion(FP-2),eriosematin(FP-3),scoparone(FP-4),lupeol(FP-5),betulinic acid(FP-6),3\',4\'-Dihydroxy-trans-cinamic acid octacosyl ester(FP-7),β-sitosterol (FP-8),flemiphilippinone A(FP-9),monopalmitin(FP-10),emodin(FP-11),islandicin (FP-12),salicylic acid(FP-13),p-methoxyphenylpropionic acid(FP-14),trideca-1, 3-diene(FP-15),lupinifolin(FP-16),flemichin D(FP-17),flemiphilippinin A(FP-18), auriculasin(FP-19),erythrinin B(FP-20),6-C-prenylluteolin(FP-21), 8-(1,1-dimethylallyl) genistein(FP-22),flemiphilippinin E(FP-23),flemiphilippinin F (FP-24),5,7,3\',4\'-tetrahydroxy-6,8-diprenylisoflavone(FP-25),flemiphilippinin D (FP-26),dorsmaninsⅠ(FP-27),osajin(FP-28),6,8-diprenyleriodictyol(FP-29), lupinalbin A(FP-30),genistein(FP-31),3\'-O-methylorobol(FP-32),orobol(FP-33), 5,7,2\',3\',4\'-pentahrdroxyflavone(FP-34),the mixture of biochanin A and prunetin (FP-35 and 36),genistin(FP-37),sophororicoside(FP-38),3\'-O-methylorobol-7-glucoside(FP-39),the mixture of sissotrin and prunetin 4\'-O-β-D-glucoside(FP-40 and 41),adenosine(FP-42) and luteoloside(FP-43,mixture).

这些化合物分别为大黄酚(FP-1)、大黄素甲醚(FP-2)、eriosematin(FP-3)、滨蒿内酯(FP-4)、羽扇豆醇(FP-5)、白桦酸(FP-6)、咖啡酸二十八烷酯(FP-7)、β-谷甾醇(FP-8)、蔓性千斤拔酮A(FP-9)、单棕榈酸甘油酯(FP-10)、大黄素(FP-11)、islandicin(FP-12)、水杨酸(FP-13)、对甲氧基苯丙酸(FP-14)、十三烷-1，4-二烯烃(FP-15)、lupinifolin(FP-16)、千斤拔素D(FP-17)、蔓性千斤拔素A(FP-18)、auriculasin(FP-19)、erythrinin B(FP-20)、6-C-异戊烯基木犀草素(FP-21)、8-(1，1-二甲烯丙基)-染料木黄酮(FP-22)、蔓性千斤拔素E(FP-23)、蔓性千斤拔素F(FP-24)、5，7，3′，4′-四羟基-6，8-双异戊烯基异黄酮(FP-25)、蔓性千斤拔素D(FP-26)、dorsmaninsⅠ(FP-27)、osajin(FP-28)、6，8-双异戊烯基圣草素(FP-29)、lupinalbin A(FP-30)、染料木黄酮(FP-31)、3\'-O-甲基香豌豆苷元(FP-32)、奥洛醇(FP-33)、5，7，2′，3′，4′-五羟基黄酮(FP-34)、鹰嘴豆素甲和樱黄素的混合物(FP-35和FP-36)、染料木苷(FP-37)、槐属苷(FP-38)、7-葡萄糖基-3\'-O-甲基香豌豆苷(FP-39)、印度黄檀苷和樱黄素4′-O-β-D-葡萄糖苷的混合物(FP-40和FP-41)、腺嘌呤核苷(FP-42)和木犀草苷(FP-43，混合物)。

Advances in Research on Plants Reactions under Phosphate Starvation;2. Topics discussed in this article includes synthesis and structures of R2M24, the reactions of its metal-metal triple bond with various reagents such as nucleophiles, carbon-carbon mu.

本文对一类重要的ⅥB族金属叁键化合物R_2M_2_4(R为环戊二烯基及类环戊二烯基)近年来的研究成果进行了综述，综述重点是这类化合物的官能团M≡M参键的化学活性，全文包括R_2M_2_4的合成及结构，M≡M叁键与亲核试剂、与碳-碳重键，与氧或与金属羰基物等试剂的反应及其应用。

Topics discussed in this article includes synthesis and structures of R2M24, the reactions of its metal-metal triple bond with various reagents such as nucleophiles, carbon-carbon mu.

本文对一类重要的ⅥB族金属叁键化合物R_2M_2_4(R为环戊二烯基及类环戊二烯基)近年来的研究成果进行了综述，综述重点是这类化合物的官能团M≡M参键的化学活性，全文包括R_2M_2_4的合成及结构，M≡M叁键与亲核试剂、与碳-碳重键，与氧或与金属羰基物等试剂的反应及其应用。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。