戊四唑

A drug, C6H10N4, that is a stimulant of the central nervous system and is used chiefly as an analeptic.

戊四唑一种对中枢神经系统有刺激的药物c6h10n4，主要用作兴奋剂

MethodsⅠMaximal electroshock seizure was adopted to analyse the relative of dose and effect, relative of time and effect, including maximal efficacy and potency of these five extractives in mice given by ig administration.ⅡMetrazol seizure test was used to compare seizure latency, anticonvulsant rate and mortality of mice with every extractives.ⅢPharmacodynamic parameters of five alcoholic extractives were assayed by means of Pharmacological Effective Method.ⅣUsing the model of seizure rats induced by penicillin localized injected in cortex,we studied the effect of extractives on seizure latency, frequency of epileptiform discharge, highest wave of hippocampus EEG(Recoded by RM6240C multichannel physiological signal collection and analysis recorde), the changes of convulsant behaviors and the latency of seizure.

方法①采用最大电休克惊厥模型，分析灌胃小鼠各药的量效和时效关系，比较其效价强度和效能；②采用戊四唑惊厥模型，比较ig小鼠各药的惊厥潜伏期、抗惊厥率和死亡率；③采用药效法，运用数学模式及参数来模拟各药在体内的药效动力学过程；④制备大鼠皮层定位注射青霉素点燃模型，采用RM6240C型多道生理信号采集处理系统记录脑电图，比较ig各药对痫性发作潜伏期及发作程度、痫性放电潜伏期、痫波发放频率及最高波幅的影响；⑤采用HPLC法测定海马区癫痫相关递质的含量，比较各药对Glu、Asp、Gly、GABA的影响。

After pretreated with antagonist of α 2 noradrenoceptors yohimbine 2 mg·kg -1 ip,the effects of clonidine on kindled rats was then o...

中枢突触后α2 去甲肾上腺素受体参与大鼠杏仁核电刺激点燃和戊四唑化学点燃的调控作用

Methods Sample dosages were used 15mg,20mg,25mg/ by gstro gavage.The conrulsion rates was induced by maximum electric shock,ip cardiazin mice and lateral intracereral injection of curine in rats were observed.

方法采用克癫胶囊251、5、20mg/灌胃给药，观察最大电休克致小鼠惊厥率和筒箭毒碱侧脑室注射致大鼠惊厥率及戊四唑诱发小鼠惊厥的抗惊厥作用。

The animals were sacrificed 55 minutes later, then immunohistochemical methods were used to show the change of nNOS in hippocamp.

采用免疫组织化学法，观察中药复方对戊四唑致痫小鼠nNOS表达的影响。

The effects of Caoguozhimu Decoction, a TCM antiepileptic, on NMDA receptor binding capacity and the expression of NMDAR1 mRNA in pentylene tetrazole-kindled rat model were observerd by the ligand-receptor method and i n situ hybridization, with MK-801 as a contrast.

观察抗癫痫中药草果知母汤在阻断戊四唑点燃模型形成过程中，对兴奋性氨基酸类神经递质Glu的受体NMDA结合力及其NMDAR1 mRNA的影响。以NMDA的竞争性拮抗剂MK- 801为对照，用配基受体法、原位杂交法检测相应指标的变化。

A trademark used for a medicinal preparation of meperidine.

戊撑四唑，卡地阿佐戊四氮的一个商标名

Methods:By pentylenetetrazol kindling in chemical method, we built the chronic epilepsy model.

采用戊四唑化学点燃方法，建立慢性癫痫模型。

Objective: To study the antagonism of dihydropyridine calcium channel blocker nicardipine against pentylenetetrazol kindling.

目的：研究二氢吡啶类钙通道阻滞剂尼卡地平对大鼠戊四唑化学性点燃的拮抗作用。

METHODS Electricalamygdala kindling, pentylenetetrazol kindling models in rats and maximalelectroshock in mice were used to observe the effects of β-AR agonists andantagonists.

建立大鼠杏仁核电刺激点燃和戊四唑化学性点燃模型，观察β-AR亚型激动剂和拮抗剂对点燃和小鼠最大电休克的影响。

For a big chunk of credit-card losses; the number of filings (and thus charge-off rates) would be rising again, whether

年美国个人破产法的一个改动使得破产登记急速下降，而后引起了信用卡大规模的亏损。

Eph. 4:23 And that you be renewed in the spirit of your mind

弗四23 而在你们心思的灵里得以更新