慢性

Objective To investigate the application of anterolateral thigh fasciocutaneous flap on abdominal chronic ulcer,and provide evidence for its clinical use. Methods From Oct 2005 to Dec 2008,5patients with abdominal ulcer caused by different reasons were repaired with anterolateral thigh fasciocutaneous flap, the flap pedicled with rami descenden of lateral circumflex femoral artery was designed according to the size of abdominal defect,the vessel pedicle was dissociated adequately, the flap was transferred to the abdominal wound under appropriate tension through tunnel, the donor site was sutured directly or repaired with skin-grafting. Results The anterolateral thigh fasciocutaneous flap survived well in all 5 patients,there were no other complication such as skin necrosis.

目的：探讨股前外侧皮瓣在下腹部慢性溃疡中的作用，为其临床应用提供依据；方法：2005年10月～2008年12月间，对5例不同原因引起的下腹部慢性溃疡患者进行修复，术前根据腹部组织缺损的大小设计以旋股外侧动脉降支为血管蒂的岛状股前外侧皮瓣，充分游离血管蒂部，在合适张力下经过皮下或开放隧道将皮瓣带蒂转移至下腹部创面，供区直接缝合或植皮修复。

Part I Role of glycogen synthase kinase 3 in squamous differentiation induced by cigarette smoke in porcine airway epithelial cell Squamous differentiation of airway epithelium induced by diverse stimuli, such as cigarette smoke, has been thought to be an adaptive response to chronic injury as well as a precancerous lesion of lung squamous carcinoma.

第一部分糖原合成酶激酶3在吸烟诱导的猪气道上皮细胞鳞状分化中的作用研究气道上皮的鳞状细胞化生常见于慢性支气管炎症、致癌剂刺激等，一般被认为是对慢性损伤的一种适应性反应，也是肺鳞癌的癌前病变，其分子机制尚未完全阐明。

Results The morality rate was zero and there were no cases of leakage at the pancraticojejunostomy and choledocojejunostomy. All patients were discharged from hospital 10-14 days after operation. Postoperative follow-up of long-term choronic complications showed only one patient (3.33%) suffered from chronic steatorrhea and malnutrition, the remaining 29 cases (96.67%) had a good function of digestion and normal nutrition. There were no cases of biler reflux gastric disease, retrograde infection, anastomostic ulcer of gastrojejunostomy, and dumping syndrome.

结果 本组手术死亡率为0，无胰、胆肠吻合漏发生，30例均于术后10～14天康复出院，术后远期慢性并发症随访显示，仅1例(3.33％)患慢性脂肪痢和营养不良症，余29例(96.67％)消化吸收功能正常，营养状况良好，全组无胆汁返流性胃炎、吻合口溃疡、上行性感染和倾倒综合征发生。

The possible inuence of mainly immunological risk factors early after transplantation leads to manifestation of CAN in a shorter period. 4. The study showed no impact of C4d expression on mean serum creatinine levels at the time of biopsy and during 1-year observation. More patients with peritubular C4d deposition lost their grafts during the study period. 5. Deficiency syndrome-type with CAN usually are spleen-kidney Qi deficiency and hepatic and renal Yin deficiency; Sthenia syndrome with CAN usually are syndrome of blood stasis and damp-heat syndrome

并且发生CAN时间早于阴性组；体液免疫因素在慢性移植物肾病早期可能是一个重要危险因素；4、两组的肌酐水平在穿刺时及穿刺后1、3、6、12月没有统计学意义，但C4d阳性组穿刺后1年内失功率高且预后差；5、慢性移植物肾病患者的中医证型特点是本虚标实；本虚主要是脾肾气虚、肝肾阴虚，标实主要是血瘀、湿热。

The surgery of submucous correction of nasal septum in evaluation is effective in treating chronic sinusitis.

鼻中隔偏曲在慢性鼻窦炎的发生发展中起着重要的作用，行鼻中隔矫正能达到治疗慢性鼻窦炎的目的。

Pediatric chronic pain patients previously underthe care of another subspecialist and subsequently referredto an anesthesiology-based pediatric chronic pain medicine programseemed to be experiencing significantly worse health-relatedquality of life.

患有慢性疼痛的病儿在接受麻醉为基础的慢性疼痛治疗计划之前，大多接受过其他亚专科的治疗，其健康相关的生活质量明显较低。

Chronic hepatitis B patients without （50 cases） or with superinfection with hepatitis A （50 cases） or with hepatitis E （50 cases） were included in this study.

方法慢性乙型肝炎重叠甲型肝炎组50例，慢性乙型肝炎重叠戊型肝炎组50例和单纯乙型肝炎组50例，其中每组各含4例肝硬化患者；对3组患者的临床表现实验室检查等进行对比分析。

Objective:To investigate the correlation among hepatitis B virus markers in gastric juice,serum and gastric mucosa in chronic patients with hepatitis B virus infection,the influence of HBV infection on gastric mucosa in chronic hepatitis B patients,and the possibility of infection by alimentary canal.

目的：通过研究慢性乙型肝炎病毒感染者胃液、胃粘膜及血清中乙肝病毒标志物的存在情况，分析它们之间的相互关系，以探讨乙型肝炎病毒感染对慢性乙型肝炎病毒感染者胃黏膜病变的影响及乙型肝炎病毒消化道传播的可能性。

Chronic high insulin results in down-regulation of PKB threonine phosphorylation and insulin gene expression in HIT-T15 Cells.

慢性高浓度胰岛素慢性刺激可下调HIT-T15细胞PKB苏氨酸磷酸化及胰岛素基因表达。

Background Slowly activating delayed rectifier potassium currentI_(Ks is important in therepolarization of human cardiomyocyte action potential,especially in forming andmaintaining plateau of action potential. I_ channel is combined byαandβsubunits,which are coded by KCNQ1 and KCNE1 respectively. Mutations ofhKCNQ1/hKCNE1 genes,chronic myocardial hypertrophy and chronic heartfailure will lead to dysfunction of I_ and ingenital or acquired LQTS which areimportant factor in hazardous ventricular arrhythmia such as Torsade depoints.

实验背景缓慢激活延迟整流钾电流I_(Ks是参与人心肌细胞动作电位复极，特别是平台期形成与维持的重要外向离子流。I_通道由KCNQ1基因编码的α亚单位及KCNE1基因编码的β亚单位组成。hKCNQ1/hKCNE1基因突变或慢性心肌肥厚、慢性心力衰竭等病理过程均可导致I_功能异常，引起遗传性或获得性长QT综合征，LQTS易引起尖端扭转型室性心动过速等心律失常，从而危及病人生命。

And Pharaoh spoke to Joseph, saying, Your father and your brothers have come to you.

47：5 法老对约瑟说，你父亲和你弟兄们到你这里来了。

Additionally, the approximate flattening of surface strip using lines linking midpoints on perpendicular lines between geodesic curves and the unconditional extreme value method are discussed.

提出了用测地线方程、曲面上两点间短程线来计算膜结构曲面测地线的方法，同时，采用测地线间垂线的中点连线和用无约束极值法进行空间条状曲面近似展开的分析。