意义重大

Of housing as a social security nature products for the Home Ownership and presence of major significance.

经济适用房作为社会保障性的产品为使居者有其屋而存在意义重大。

It was actually quite momentous that she left.

实际上，她的离开意义重大。

Yes, that's a mouthful.

是的，意义重大的。

That the moneyed are munificent is welcome , but that the best brains in business take the giving seriously matters , too

有钱人愿意慷慨解囊当然是好事，不过这些商业精英能认真处理捐赠也是意义重大。

It is significant to note that these are the words of a foreign Naval Architect and Shipbuilding Expert.

留意这些外国海军建筑师和造船专家的措辞是意义重大的。

Nero: What? I thought this meant a lot to you...

什么？我觉得这个东西对你意义重大。

"The timing of this alliance is critical for the future health of the industry," commented Mike Wallenfels, president of Mountain Hardwear and chairman of the OIA Board of Directors.

对于这次合作Mountain Hardwear董事长暨美国户外产业协会理事会主席Mike Wallenfels表示：此次战略联盟的建立对美国户外产业的健康发展意义重大。

Opel is of critical importance to GM's future.

欧宝对通用汽车的未来意义重大。

As an improvement of prosecutor over-all qualities is significant to the reform of prosecutor system and the judicial reform.

作为司法官员重要组成部分的检察官，他们的整体素质的提高对检察体制改革，对司法改革意义重大。

Ultimately, vulnerable groups of neurons atrophy and die in a process that may involve excitotoxicity (overstimulation of neurotransmitter receptors on neuronal surface membranes), collapse of calcium homeostasis, inflammation, and depletion of energy and growth factors. A form of apolipoprotein E, apoE4, contributes to the abnormal accumulation of A and tau, but probably also damages mitochondria and the cellular cytoskeleton. A , tau, apoE and -synuclein interact with many other molecules and modulate diverse signalling cascades that regulate neuronal activity and survival.

最后，易感神经元会萎缩直至死亡，原因可能有兴奋性中毒（神经递质对神经元表面受体的过度刺激引起），钙稳态失衡，炎症反应，能量和生长因子的耗尽。apoE4的产生可导致A肽和tau蛋白的异常聚合，可能也损害线粒体和细胞骨架。A肽、tau蛋白、apoE和突触核蛋白可与很多分子反应，也可调节不同信号级联反应，这些级联反应对于维持神经元活动性和生存性意义重大。

With Death guitarist Schuldiner adopting vocal duties, the band made a major impact on the scene.

随着死亡的吉他手Schuldiner接受主唱的职务，乐队在现实中树立了重要的影响。

But he could still end up breakfasting on Swiss-government issue muesli because all six are accused of nicking around 45 million pounds they should have paid to FIFA.

不过他最后仍有可能沦为瑞士政府&议事餐桌&上的一道早餐，因为这所有六个人都被指控把本应支付给国际足联的大约4500万英镑骗了个精光。