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The anticonvulsive effect of etomidate varies in degree in the four experimental models of convulsion.

依托咪酯对小鼠电惊厥、士的宁、NMDA及利多卡因惊厥均有拮抗作用。

Objective To set up an animal model of subthreshold convulsant discharges and to study the effects of SCD on learning and memory ability of space changes in rats.

目的 建立惊厥阈下脑放电动物模型,研究惊厥阈下脑放电对大鼠空间变换学习记忆的影响。

Methods: Totally 16 healthy adult rabbits of both sexes were randomly divided into SP group and NS group. The rabbits in SP and NS group were given Thiopental (3 mg/kg) and normal saline (1 ml/kg) respectively by intravenous injection via ear vein after establishing convulsant models by injecting Strychnine into the other ear vein. QPEEG and power spectral analysis were used to analyze the changes of δ-band of QPEEG in convulsant rabbits before and after administering drugs.

成年家兔16只,雌雄不限,随机分为硫喷妥钠组和生理盐水组,每组8只,在建立惊厥兔模型后,分别耳缘静脉注射硫喷妥钠3 mg/kg、生理盐水1 ml/kg,应用QPEEG,采用功率谱分析法,分析惊厥家兔给药前后QPEEG δ频段的变化。

METHODS In convulsive mice caused by strychnine to observe the latent period of convulsion,dying time,mortality in mice.

采用士的宁致小鼠惊厥法,观察酸枣仁生物碱对小鼠惊厥潜伏期、死亡时间和死亡率的影响。

Phenothiazine compounds should not be used in patients receiving large doses of hypnotics, and should be used, with caution in patients with a history of convulssive disorders, since grand mal convulsions have been known to occur.

接受大剂量安眠药的患者不应使用吩噻嗪化合对有惊厥病史的患者应慎用,物,对有惊厥病史的患者应慎用,因为已知有发生过癫痫大发作。生过癫痫大发作。

For lidocaine, 100 mice were divided into 10 groups,with10rates in each group who received dose of 183.11, 163.77, 146.48,131.02, 117.19, 93.75, 75.00, 60.00, 48.00, 38.40 mg/kg respectively. For each local anes thetic, the rates of convulsion or death were tried to distribute on both sides of 50% symmetrically.

不同剂量的局麻药腹腔注射时,尽量使每种麻醉药致各组小鼠的惊厥率和致死率对称分布在50%左右,给药5 min后记录各组的致惊厥率和死亡率。

The effects of single and multiple seizures on cholecystokinin mRNA levels in amygdala of audiogenic seizure-prone rats (P77PMC) were examined by in situ hybridization.

铃声刺激诱发惊厥,原位杂交法检测遗传性听源性癫痫易感大鼠(P77PMC)一次与多次惊厥发作对杏仁核内胆囊收缩素 mRNA含量的影响。

Transgenic expression of IL-1ra and degree of audiogenic seizure of P77PMC rats were observed after infection with pHSV-IL-1ra virus (〓 virus particles) by i. c. v injection and hippocampus injection. Results show: 1. Overexpression of IL-1ra by pHSV-IL-1ra significantly inhibited seizure attacks of P77PMC rat.

实验结果提示IL-1β可导致神经细胞NMDAR mRNA表达及受体活性增加,从而使其兴奋性增高;脑中内源性IL-1系统的异常很可能是形成P77PMC遗传癫痫易感大鼠惊厥易感性的重要因素之一;我们首次构建并鉴定了pHSV-IL-lra重组质粒,并成功地进行了脑内基因转移,使P77PMC大鼠的惊厥程度明显降低。

Objective To explore the clinical value of rectal administration of clonazepam solution for seizure control in children.

安定溶液直肠给药能及时控制惊厥发作,这对静脉穿刺困难或医院外惊厥发作的现场急救有重要价值。

The ictal group included 21 infants, serum PRL levels were signisicantly higher at the first time than at the second time, and also higher than the same time of nonictal group and control group;②.

无惊厥组第1时间点的血清PRL水平与第2时间点无明显差异,低于惊厥组,却明显高于对照组。③。

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