惊厥的

RESULTS: Both two recipes showed potent antifebril,anticonvulsive and sedative effects.

采用酵母引起的大鼠发热模型、伤寒副伤寒疫苗引起的兔发热模型、士的宁致小鼠惊厥及电惊厥模型等观察了2种配方的解热、抗惊厥和镇静作用。

The effect of different dose of lidocaine on conclusion duration and c-fos expression in brain with different doses.Forty mice were divided into 4 groups with 10 rates in each group who received 0, 30％, 60％ and 90％ convulsant doses of lidocaine intraperitoneally.

不同剂量利多卡因对小鼠惊厥时间和大脑c-Fos表达的影响：选择40只小鼠，随机分成4组：空白对照组、30％致惊厥剂量组、60％致惊厥剂量组、90％致惊厥剂量组，10只/组。

Methods Three doses of etomidate were administered intraperitoneally. Five minutcs later, convulsion was induced by electricity or drugs . The convulsant latency, duration of tonic state, incidence of convulsion, mortality and survival time were noted.

以电刺激或致惊剂〔士的宁、N-甲基－D-天冬氨酸、利多卡因〕建立不同类型的小鼠惊厥模型，观察腹腔注射3种剂量的依托咪酯对小鼠强直性惊厥潜伏期、持续期、惊厥发生率、小鼠死亡率以及小鼠存活时间的影响。

Methods Three doses of etomidate were administered intraperitoneally.Five minutcs later,convulsion was induced by electricity or drugs ［strychnine.N-methyl-D-aspartate.lidocanine］.The convulsant latency,duration of tonic state,incidence of con-vulsion,mortality and survival time were noted.

以电刺激或致惊剂〔士的宁、N-甲基-D-天冬氨酸、利多卡因〕建立不同类型的小鼠惊厥模型，观察腹腔注射3种剂量的依托咪酯对小鼠强直性惊厥潜伏期、持续期、惊厥发生率、小鼠死亡率以及小鼠存活时间的影响。

MethodsⅠMaximal electroshock seizure was adopted to analyse the relative of dose and effect, relative of time and effect, including maximal efficacy and potency of these five extractives in mice given by ig administration.ⅡMetrazol seizure test was used to compare seizure latency, anticonvulsant rate and mortality of mice with every extractives.ⅢPharmacodynamic parameters of five alcoholic extractives were assayed by means of Pharmacological Effective Method.ⅣUsing the model of seizure rats induced by penicillin localized injected in cortex,we studied the effect of extractives on seizure latency, frequency of epileptiform discharge, highest wave of hippocampus EEG(Recoded by RM6240C multichannel physiological signal collection and analysis recorde), the changes of convulsant behaviors and the latency of seizure.

方法①采用最大电休克惊厥模型，分析灌胃小鼠各药的量效和时效关系，比较其效价强度和效能；②采用戊四唑惊厥模型，比较ig小鼠各药的惊厥潜伏期、抗惊厥率和死亡率；③采用药效法，运用数学模式及参数来模拟各药在体内的药效动力学过程；④制备大鼠皮层定位注射青霉素点燃模型，采用RM6240C型多道生理信号采集处理系统记录脑电图，比较ig各药对痫性发作潜伏期及发作程度、痫性放电潜伏期、痫波发放频率及最高波幅的影响；⑤采用HPLC法测定海马区癫痫相关递质的含量，比较各药对Glu、Asp、Gly、GABA的影响。

IL-1βmRNA expression in the developmental brain in Wistar rat: IL-1β mRNA in hippocampus, cerebral cortex and subcortex was detected by postnatal day 1 and gradually increased with development, reached a peak at postnatal day 21, and then gradually decreased to lower level at adult; In P77PMC rat, IL-1β mRNA expression was similar to Wistar rat before postnatal day 14, then gradually increased and surpassed Wistar rat at postnatal day 28, reached a peak in adult.

原位杂交显示谷氨酸诱导Wistar大鼠惊厥和P77PMC大鼠听源性惊厥后脑内IL-1βmRNA表达情况。结果发现，两种不同惊厥模型大鼠惊厥后脑内IL-1βmRNA表达存在明显的差异。谷氨酸引起惊厥诱导脑内皮层、海马和丘脑IL-1βmRNA表达增高的程度远较P77PMC大鼠听源性惊厥为低，而且惊厥后IL-1βmRNA表达增加较慢，于4-8h达高峰，而听源性惊厥可于惊厥后2h迅速达高峰。但两种形式惊厥诱导脑内IL-1βmRNA表达最高的部位均是海马。

Periaqueductal gray neurons exhibit increased responsiveness associated with audiogenic seizures in the genetically epilepsy-prone rat.

总之，听源性惊厥发作诱导PAG内大量神经元表达c-fos基因，揭示了PAG内神经元功能活动的剧烈改变，N'Gouemo［12］的电生理研究也发现，听源性惊厥易感大鼠PAG内许多神经元表现为异常的高反应性状态，而且出现与强直相关的神经元异常放电，这些都进一步说明PAG参与了听源性惊厥发作过程，但其中的神经化学机制尚需进一步探讨。

RESULTS: The latency of the first seizure in group A was longer than that in group B, while the seizure times in group A was less than that in group B. Besides, in group A, both the neuron loss amount in the hippocampus and hilus and the GAD positive cell loss amount in the hippocampus were less than those in group B.

结果：牛黄防治组惊厥发作的潜伏时间较对照组长，发作次数较惊厥组少，而在海马及门区的神经元和在海马的GAD阳性细胞的丢失数量较惊厥组的少。

IL-1ra could reduce the frequency of epi leptiform discharges in acute seizure, but had no effect on latencies of seizure attack and epileptiform discharges or on acute seizure degree.

IL -1ra能减少急性惊厥痫波发放频率，对急性惊厥发作及痫波发放的潜伏期和惊厥发作强度无明显影响。

IL-1ra could reduce the frequency of epi leptiform discharges in acute seizure, but had no effect on latencies of seizure attack and epileptiform discharges or on acute seizure degree.

IL -1ra能减少急性惊厥痫波发放频率，对急性惊厥发作及痫波发放的潜伏期和惊厥发作强度无手术明显影响。

By the time of its fall, most of the prisoners were writers who had written against the corruptions of the government.

到它被攻陷的时候，里面多数的犯人是写了反对政府贪污文章的作家。

The most obvious variation to ovum morphological character was that the color was changed from light green to sepiaceous in embryonic development, and all the ovums were almost hatched after 96h.

在胚胎发育过程中卵的形态特征最明显的变化是颜色从淡绿到深褐色，卵在发育96h后卵基本全部孵化。