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The dose-response curve of histamine was shifted parallely to the right. pA2 was 9.34±0.61. The guinea-pigs were effectively reduced the rate of histamine induced death, decreased reaction extent of shock (P<0.01) and prolonged latency period of shock (P<0.05) by orally administered cetirizine ranged from 0.1, 0.2 and 0.4 mg.kg-1. The capillary permeability to intracutaneous injection of histamine was potently inhibited by orally administered cetirizine ranged from 0.0625 to 0.25 mg.kg-1 in mice, blue area obviously decreased (P<0.01), and dose-response curve existed obviously. In which the effect of these dosage groups were superior to the group of chlorphenamine.

结果:西替利嗪3×10-8~3×10-7mol.L-1可剂量依赖性地对抗组胺引起的肠肌收缩,使组胺的量效曲线平行右移,pA2为9.34 ± s 0.61,西替利嗪0.1,0.2及0.4 mg.kg-1口服给药时,能明显减轻豚鼠静脉注射组胺所致休克反应的严重程度(P<0.01),并可延长豚鼠惊厥反应的潜伏期及降低死亡率(P<0.05),西替利嗪0.0625~0.25 mg.kg-1口服给药可显著对抗组胺引起的小鼠皮肤血管通透性的增高,使蓝染面积显著缩小(P<0.01),且存在明显的量效关系,3个剂量组的作用均优于氯苯那敏组。

Convulsion was induced by intravenous strychnine 0.25 mgkg^(-1. Normal saline and the different dose of ketamine were intravenously administered, respectively. Mortality and duration of tonic state were observed. The EEG activity was monitored continuatively.

耳缘静脉注射士的宁0.25mgkg^(-1)制作惊厥模型,分别静脉注射氯胺酮或相应剂量的生理盐水,观察氯胺酮对家兔的死亡率和强直持续期的影响。

The pertussis vaccine may cause fever as high as 106 degrees, pain, swelling, diarrhea, projectile vomiting, excessive sleepiness, high-pitched screaming (not unlike the so-called cri encephalique, or encephalitic scream associated with central nervous system damage), inconsolable crying bouts, seizures, convulsions, collapse, shock, breathing problems, brain damage, and sudden infant death syndrome.

百日咳疫苗也许会引起高达106华氏度的高烧,疼痛,肿胀,腹泻,喷射式呕吐,整天昏昏欲睡,高声调的尖叫(和称为喊叫脑炎或者与中枢神经系统损伤的脑炎尖叫相象),难以自拔的不断叫喊,惊厥,抽搐,虚脱,休克,呼吸困难,脑部损伤以及婴儿卒死综合症。

Researchers concluded,"This patient's positive rechallenge for seizure activity increases suspicion that varicella vaccine may be more than a coincidental factor in observations of postvaccinal convulsions."

研究人员断定,&这个病人对于惊厥行为刺激的反应度的激发增强了对这一事件的怀疑:在对接种后的抽搐观测中,水痘疫苗也许不止是一个巧合的因素。&

In the meantime, even in their present form, the cell tra lants may still help some people - a roximately 10 percent of those with Type 1 diabetes, who frequently suffer from severe episodes of low blood sugar, or hypoglycemia, that strike without warning and can cause confusion, fainting or even seizures.

同时,即便是在他们现在的情形下,细胞移植对于大约10%的患有I型糖尿病的患者可能依然有用。这些患者经常受到严重的低血糖症状或者低血糖症的折磨,这些疾病会在没有任何征兆的情况下发生,并能诱发神志不清、昏迷甚至惊厥。

Patients with mild or moderate hepatic failure or intestinal fat-malabsorption syndromes, as well as patients who are taking anticonulsant medications, glucocorticoids, or other drugs that actiate steroid and xenobiotic receptor, require higher doses of itamin D (Table 3).7,88 Exposure to sunlight or ultraiolet B radiation from a tanning bed or other ultraiolet B–emitting deice is also effectie.

有几类病人需要更高剂量的维生素D(表3)[7,88],如轻中度肝功能不全、肠脂肪吸收不良综合征的病人,服用抗惊厥类、糖皮质激素类以及可激活类固醇和异生质受体类药物的病人。病人通过适当的日光照射、躺在晒黑床上紫外线B照射或其他紫外线B放射仪治疗,也能取得增加维生素D用量的效果。

Methods: After intranasal or intraperitoneal administration of r-HuEPO, the behavioral and electroencephalographic changes were observed in pentylenetetrazol and maximal electroshock induced seizure or electrical amygdaloid-kindled seizure of rats.

另外,大鼠经鼻给r-HuEPO后,观察对最大电休克诱导的惊厥发作级别,前肢或后肢强直性伸展时间的影响;对杏仁核电点燃后阈刺激诱导的行为等级,大发作持续时间及后放电的影响。

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