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Objective To observe the effect of acrous gramineus and its main component α-asarone on eclamptic behaviors and frontal lobe discharge in the young rats with experimental epilepsy induced by pentylenetetrazol.

目的:观察中药石菖蒲及其主要成分α-细辛醚对戊四氮诱发的实验性癫痫幼鼠惊厥行为和额叶皮层放电的影响。

Objective To observe the effect of acrous g ramineus and its main component α-asarone on eclamptic behaviors and frontal lobe discharge in the young rats with experimental epilepsy induced by pentylenetetrazol.

目的:观察中药石菖蒲及其主要成分α-细辛醚对戊四氮诱发的实验性癫痫幼鼠惊厥行为和额叶皮层放电的影响。

The COD value in the dorsal and dorsolateral subdivisions of the PAG in the kindled audiogenic seizures-prone rats were significantly higher than that in the naive audiogenc seizures-prone rats.

用光镜观察PAG各节段各亚区切片上突触密度的变化,以期在光镜水平上了解PAG在惊厥状态下超微结构的某些变化。

Results The value of corrected optical density of the synaptophysin P38 immunoreactivity in the PAG of the naive and kindled audiogenic seizures-prone rats were significantly higher than that of the normal Wistar rats.

据此,本实验以P38免疫细胞化学反应的强度为指标,间接地对听源性惊厥易感大鼠(P77PMC)中脑导水管周围灰质(periaqueductal gray, PAG)各亚区突触的分布情况进行了研究。

The main peaks of the EEG power spectra were in delta and theta frequency range. In the stage of ethanol exposure, the rats exhibited much more act of attack than the control, the alpha waves of EEG decreased, while the delta waves increased. The EEG power spectra analysis showed the delta power increased and the theta power decreased. In the stage of ethanol withdrawal, the rats showed some withdrawal behaviors such as wet dog shakes, sniffing, groomingand tonic-clonic seizures for audiogenic stimulus. Spikes and spike-slow waves were found in the EEG. In power spectra analysis, the delta power decreased while the alpha and the theta power increased, the EEG frequency band moved to the high-frequency rang. These changes were found obviously on the sixth day and disappeared on the 1 Oth day after the ethanol was removed.

本研究发现:1、对照组大鼠行为无异常,伏核EEG以α节律为主,散在出现δ和θ节律;功率主峰在δ和θ频段范围,整个过程中未发现手术对伏核EEG及脑电功率谱有影响。2、在慢性饮酒过程中,大鼠攻击性行为增加,伏核 EEG的α节律明显减少,散在出现的高幅慢活动δ波逐渐增多,功率谱分析表明δ频段功率百分比明显增加,而θ频段功率百分比明显减少,总功率减少。3、停饮后,大鼠出现湿狗样抖动、打喷嚏等撤药综合症,并且高频声音刺激能引发惊厥;伏核EEG出现棘波和棘慢综合波,并持续增多,功率谱分析显示δ频段功率百分比 5 南京医科大学硕士学位论文逐渐减少,而0和以频段功率百分比逐渐增加,总功率增加。

objective to set up mode of management,prevention and cure on epilepsy among rural population in ningxia by primary medical care system,then extend toward others rural regions.methods doctors in county,countryside and villege level were trained how to screen,diagnose,prevention and treat epilepsy among 140 countrysides and 3,786 thousand rural populations in ningxia.cluster sampling was adopted to screen convulsibility epileptics,to freely treat with pb.

目的 建立宁夏农村地区癫痫的防治和管理有效模式,并逐步向其它农村地区推广。方法采取整群抽样方法,选择宁夏农村地区140个乡,共计378.6万人群。通过对县、乡、村医生的专业培训,筛选惊厥性癫痫患者,采用苯巴比妥单药免费治疗,分别在第3、6、9和12个月对其疗效进行评估。结果培训了172名县、乡、村医生。

Some of derivatives of 3-substitutedphthalides were obtained by reduction of derivatives of 3-phthalidylacetic amides by borane-methyl sulfide complex in THF.

GABAa受体是中枢神经系统主要的抑制性神经递质受体,在中枢神经系统中广泛存在,是一种介导抗焦虑药物、镇静药物、抗惊厥药物、癫痫和失忆活动的多功能药物作用靶标。

Large doses of hypnotics, and should be used, with caution in patientswith a history of convulssive disorders, since grand mal convulsions havebeen known to occur.

接受大剂量安眠药的患者不应使用吩噻嗪化合物,对有惊厥病史的患者应慎用,因为已知有发生过癫痫大发作。

In the current study, we evaluated the behavioral effects of two standard drugs used clinically for neuropathic pain, the anticonvulsant gabapentin and antidepressant imipramine, in rats at different times after peripheral nerve injury.

现在的研究,我们评估了两种神经性头痛临床治疗的一线药物在老鼠周围神经损伤后不同时间段行为效应,即抗惊厥药加巴喷丁和抗抑郁药丙咪嗪。

Possible mechanism of anticonvulsant effect of ketamine in mice [J].

氯胺酮的抗惊厥作用及对兔呼吸、血压的影响[J]。

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