惊厥性

Objectives:To explore clinical characteristic of febrile convulsionand the meaning of electroencephalogram changes.

目的：探讨小儿热性惊厥的临床特点和脑电图变化的意义。

It indicated that a derivative of γ-aminobutyric acid with an imine link to a lipophilic carrier may have useful anticonvulsant activity.

通过亚胺键将一个亲脂性载体接到γ-氨基丁酸上制成的衍生物可能具有抗惊厥活性。

The dose-response curve of histamine was shifted parallely to the right. pA2 was 9.34±0.61. The guinea-pigs were effectively reduced the rate of histamine induced death, decreased reaction extent of shock (P＜0.01) and prolonged latency period of shock (P＜0.05) by orally administered cetirizine ranged from 0.1, 0.2 and 0.4 mg.kg-1. The capillary permeability to intracutaneous injection of histamine was potently inhibited by orally administered cetirizine ranged from 0.0625 to 0.25 mg.kg-1 in mice, blue area obviously decreased (P＜0.01), and dose-response curve existed obviously. In which the effect of these dosage groups were superior to the group of chlorphenamine.

结果：西替利嗪3×10-8～3×10-7mol.L-1可剂量依赖性地对抗组胺引起的肠肌收缩，使组胺的量效曲线平行右移，pA2为9.34 ± s 0.61，西替利嗪0.1，0.2及0.4 mg.kg-1口服给药时，能明显减轻豚鼠静脉注射组胺所致休克反应的严重程度(P＜0.01)，并可延长豚鼠惊厥反应的潜伏期及降低死亡率(P＜0.05)，西替利嗪0.0625～0.25 mg.kg-1口服给药可显著对抗组胺引起的小鼠皮肤血管通透性的增高，使蓝染面积显著缩小(P＜0.01)，且存在明显的量效关系，3个剂量组的作用均优于氯苯那敏组。

Objective To find out the relationship between the periaqueductal gray and the audiogenic seizures.

目的 探讨中脑导水管周围灰质与听源性惊厥的关系。

Objective To find out the changes of synaptic density in the periaqueductalgray of the naive and kindled audiogenic seizures-prone rats.

目的 分析正常及点燃后听源性惊厥易感大鼠中脑导水管周围灰质内突触密度的变化情况。

Results The value of corrected optical density of the synaptophysin P38 immunoreactivity in the PAG of the naive and kindled audiogenic seizures-prone rats were significantly higher than that of the normal Wistar rats.

据此，本实验以P38免疫细胞化学反应的强度为指标，间接地对听源性惊厥易感大鼠(P77PMC)中脑导水管周围灰质(periaqueductal gray， PAG)各亚区突触的分布情况进行了研究。

Methods The neuronalstaining method and the immunocytochemical method were used to identify the Fos-postive neurons in the PAG of the audiogenic seizures-prone rats(P77PMC) after audiogenic seizures.

用神经细胞染色和免疫细胞化学技术，观察听源性惊厥发作后易感大鼠(P77PMC)PAG内即早基因c-fos的表达情况。

Qingyangshenylycosides is a mixture of several related compounds derived from the root of a Traditional Chinese Medicine, Cynanchum Otophyllum. Pharmacological characterization of the compounds indicated that the drug had a significant antiepileptic and anticonvulsant activity on kindling, rat audiogenic seizures and ferrous sulfate-induced epilepsy.

青阳参总甙(Qingyangshenylycosides，QYS)是萝摩科鹅绒属植物青阳参根粉提取物，已有动物实验表明QYS对大鼠听源性惊厥(audiogenic seizure，AGS)发作、&点燃&效应以及硫酸亚铁诱导的癫痫发作具有明显的对抗作用，表现出显著的抗癫痫效应。

These circumstances are believed to cause metabolic disturbances in neurons in the hippocampus, which may disappear and be subsequently replaced by gliosis.

MTS被认为与婴幼儿其的发热性惊厥和持续癫痫状态相关，这些事件被认为引起了海马区神经元代谢异常，这些神经元丢失并被神经胶质所取代。

Methods: Blood now velocity and spectral pattern of cerebral artery in forty-five healthy children and thirty-six children with hyperpyretic convulsion were detected by Transcranial Doppler ultrasound.

采用经颅多普勒超声技术，测定 36例发热性惊厥患儿及 45名健康儿童脑底动脉血流速值和频谱形态。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。