惊厥性

Result: Both doses of SAE and verapamil ig all raised the convulsant threshold of phenytoin-resistant rats (480.38±18.48)μA, there were statistical differences ( P .05) compared to themselves before drugs-treated.

结果：全蝎乙醇提取物2种剂量及维拉帕米，均可使耐苯妥英钠大鼠惊厥阈值(480.38±18.48)μA明显升高，与惊厥模型组和耐苯妥英钠惊厥模型组相比均有显著性差异( P 。01)。

MethodsⅠMaximal electroshock seizure was adopted to analyse the relative of dose and effect, relative of time and effect, including maximal efficacy and potency of these five extractives in mice given by ig administration.ⅡMetrazol seizure test was used to compare seizure latency, anticonvulsant rate and mortality of mice with every extractives.ⅢPharmacodynamic parameters of five alcoholic extractives were assayed by means of Pharmacological Effective Method.ⅣUsing the model of seizure rats induced by penicillin localized injected in cortex,we studied the effect of extractives on seizure latency, frequency of epileptiform discharge, highest wave of hippocampus EEG(Recoded by RM6240C multichannel physiological signal collection and analysis recorde), the changes of convulsant behaviors and the latency of seizure.

方法①采用最大电休克惊厥模型，分析灌胃小鼠各药的量效和时效关系，比较其效价强度和效能；②采用戊四唑惊厥模型，比较ig小鼠各药的惊厥潜伏期、抗惊厥率和死亡率；③采用药效法，运用数学模式及参数来模拟各药在体内的药效动力学过程；④制备大鼠皮层定位注射青霉素点燃模型，采用RM6240C型多道生理信号采集处理系统记录脑电图，比较ig各药对痫性发作潜伏期及发作程度、痫性放电潜伏期、痫波发放频率及最高波幅的影响；⑤采用HPLC法测定海马区癫痫相关递质的含量，比较各药对Glu、Asp、Gly、GABA的影响。

IL-1βmRNA expression in the developmental brain in Wistar rat: IL-1β mRNA in hippocampus, cerebral cortex and subcortex was detected by postnatal day 1 and gradually increased with development, reached a peak at postnatal day 21, and then gradually decreased to lower level at adult; In P77PMC rat, IL-1β mRNA expression was similar to Wistar rat before postnatal day 14, then gradually increased and surpassed Wistar rat at postnatal day 28, reached a peak in adult.

原位杂交显示谷氨酸诱导Wistar大鼠惊厥和P77PMC大鼠听源性惊厥后脑内IL-1βmRNA表达情况。结果发现，两种不同惊厥模型大鼠惊厥后脑内IL-1βmRNA表达存在明显的差异。谷氨酸引起惊厥诱导脑内皮层、海马和丘脑IL-1βmRNA表达增高的程度远较P77PMC大鼠听源性惊厥为低，而且惊厥后IL-1βmRNA表达增加较慢，于4-8h达高峰，而听源性惊厥可于惊厥后2h迅速达高峰。但两种形式惊厥诱导脑内IL-1βmRNA表达最高的部位均是海马。

A large number of neurons in the PAG of the audiogenic seizures-prone rats participated in the process of the audiogenic seizures.

听源性惊厥易感大鼠PAG内大量神经元参与了听源性惊厥发作过程。

Results:The three groups of P77PMC rats which experienced 30 and less than 30 times of audiogenic seizure and the Wistar control group did not display MF sprouting in dentate gyrus, however, the group of P77PMC rats which experienced 50 times of AGS was found hippocampal MF sprouting into the inner molecular layer of dentate gyrus.

结果：在全身性强直阵挛性惊厥发作次数少于30次的P77PMC大鼠以及对照的Wistar大鼠海马内均未见到MF发芽表现；而在经历50次Ⅳ～Ⅴ级听源性惊厥发作的一组P77PMC大鼠海马内观察到了MF发芽的现象，在海马齿状回内分子层内见到Timm染色呈棕黑色颗粒异常分布的MF末梢。

Periaqueductal gray neurons exhibit increased responsiveness associated with audiogenic seizures in the genetically epilepsy-prone rat.

总之，听源性惊厥发作诱导PAG内大量神经元表达c-fos基因，揭示了PAG内神经元功能活动的剧烈改变，N'Gouemo［12］的电生理研究也发现，听源性惊厥易感大鼠PAG内许多神经元表现为异常的高反应性状态，而且出现与强直相关的神经元异常放电，这些都进一步说明PAG参与了听源性惊厥发作过程，但其中的神经化学机制尚需进一步探讨。

Methods The compound preparation was administered intragastrically in mice, whose spontaneous activity was observed along with their tolerance of the preparation after long-term administration. The hypnotic effect of the compound was assessed by investigating the changes in the pentobarbital sodium-induced sleeping. The compound was tested for its antiseizure effect in mice with pentetrazole-induced clonic and tonic convulsion. Diazepam was used as the standard control in all experiments.

利用光电计数法观察灌胃给予复方酸枣仁油栀子油对小鼠自发活动的影响，以及长期使用药物对小鼠耐受性的影响；利用延长戊巴比妥钠睡眠时间实验和戊巴比妥钠阈下催眠剂量实验，观察复方酸枣仁油栀子油的催眠作用；利用戊四氮诱发小鼠阵挛性、强直性惊厥观察复方酸枣仁油栀子油的抗惊厥作用；本实验用地西泮进行平行对照实验，并进行了组方设计和实验。

Objective To explore the changes and clinical significance of neuropeptide Y and neuron-specific enolase levels in children with convulsibility diseases.

目的 探讨神经肽Y和神经元特异性烯醇化酶在小儿惊厥性疾病中的水平变化及其临床意义。

Patients with convulsibility epileptics were diagnosed.78% seizures was obviously decreased.59% seizures was ended.conclusion mode of management,prevention and cure on epilepsy among rural is effective in populations of ningxia.it is worth to make use of management,prevention and cure on many chronic diseases among rural areas in china.curative effect of pb is positive and has few side effects.it is cheap and convenient for application and extention among rural regions.

治疗效果：79%发作次数明显减少，59%发作终止，副作用随疗程的延长而减少。结论宁夏农村地区癫痫的防治和管理模式是有显著成效的，该防治管理模式对常见、多发慢性疾病在中国农村地区防治管理值得借鉴。苯巴比妥单药治疗惊厥性癫痫发作，疗效肯定，副作用少、价廉、方便，适合在农村贫困地区广泛应用和推广。

objective to set up mode of management,prevention and cure on epilepsy among rural population in ningxia by primary medical care system,then extend toward others rural regions.methods doctors in county,countryside and villege level were trained how to screen,diagnose,prevention and treat epilepsy among 140 countrysides and 3,786 thousand rural populations in ningxia.cluster sampling was adopted to screen convulsibility epileptics,to freely treat with pb.

目的 建立宁夏农村地区癫痫的防治和管理有效模式，并逐步向其它农村地区推广。方法采取整群抽样方法，选择宁夏农村地区140个乡，共计378.6万人群。通过对县、乡、村医生的专业培训，筛选惊厥性癫痫患者，采用苯巴比妥单药免费治疗，分别在第3、6、9和12个月对其疗效进行评估。结果培训了172名县、乡、村医生。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。