惊厥

Phenothiazine compounds should not be used in patients receiving large doses of hypnotics, and should be used, with caution in patients with a history of convulssive disorders, since grand mal convulsions have been known to occur.

接受大剂量安眠药的患者不应使用吩噻嗪化合对有惊厥病史的患者应慎用，物，对有惊厥病史的患者应慎用，因为已知有发生过癫痫大发作。生过癫痫大发作。

For lidocaine, 100 mice were divided into 10 groups,with10rates in each group who received dose of 183.11, 163.77, 146.48,131.02, 117.19, 93.75, 75.00, 60.00, 48.00, 38.40 mg/kg respectively. For each local anes thetic, the rates of convulsion or death were tried to distribute on both sides of 50％ symmetrically.

不同剂量的局麻药腹腔注射时，尽量使每种麻醉药致各组小鼠的惊厥率和致死率对称分布在50％左右，给药5 min后记录各组的致惊厥率和死亡率。

A large number of neurons in the PAG of the audiogenic seizures-prone rats participated in the process of the audiogenic seizures.

听源性惊厥易感大鼠PAG内大量神经元参与了听源性惊厥发作过程。

Results:The three groups of P77PMC rats which experienced 30 and less than 30 times of audiogenic seizure and the Wistar control group did not display MF sprouting in dentate gyrus, however, the group of P77PMC rats which experienced 50 times of AGS was found hippocampal MF sprouting into the inner molecular layer of dentate gyrus.

结果：在全身性强直阵挛性惊厥发作次数少于30次的P77PMC大鼠以及对照的Wistar大鼠海马内均未见到MF发芽表现；而在经历50次Ⅳ～Ⅴ级听源性惊厥发作的一组P77PMC大鼠海马内观察到了MF发芽的现象，在海马齿状回内分子层内见到Timm染色呈棕黑色颗粒异常分布的MF末梢。

The effects of single and multiple seizures on cholecystokinin mRNA levels in amygdala of audiogenic seizure-prone rats (P77PMC) were examined by in situ hybridization.

铃声刺激诱发惊厥，原位杂交法检测遗传性听源性癫痫易感大鼠(P77PMC)一次与多次惊厥发作对杏仁核内胆囊收缩素 mRNA含量的影响。

Transgenic expression of IL-1ra and degree of audiogenic seizure of P77PMC rats were observed after infection with pHSV-IL-1ra virus (〓 virus particles) by i. c. v injection and hippocampus injection. Results show: 1. Overexpression of IL-1ra by pHSV-IL-1ra significantly inhibited seizure attacks of P77PMC rat.

实验结果提示IL-1β可导致神经细胞NMDAR mRNA表达及受体活性增加，从而使其兴奋性增高；脑中内源性IL-1系统的异常很可能是形成P77PMC遗传癫痫易感大鼠惊厥易感性的重要因素之一；我们首次构建并鉴定了pHSV-IL-lra重组质粒，并成功地进行了脑内基因转移，使P77PMC大鼠的惊厥程度明显降低。

Methods The compound preparation was administered intragastrically in mice, whose spontaneous activity was observed along with their tolerance of the preparation after long-term administration. The hypnotic effect of the compound was assessed by investigating the changes in the pentobarbital sodium-induced sleeping. The compound was tested for its antiseizure effect in mice with pentetrazole-induced clonic and tonic convulsion. Diazepam was used as the standard control in all experiments.

利用光电计数法观察灌胃给予复方酸枣仁油栀子油对小鼠自发活动的影响，以及长期使用药物对小鼠耐受性的影响；利用延长戊巴比妥钠睡眠时间实验和戊巴比妥钠阈下催眠剂量实验，观察复方酸枣仁油栀子油的催眠作用；利用戊四氮诱发小鼠阵挛性、强直性惊厥观察复方酸枣仁油栀子油的抗惊厥作用；本实验用地西泮进行平行对照实验，并进行了组方设计和实验。

More neurospheres were derived from the hippocampi of mice that had exhibited prolonged seizures than from those in which seizures occurred in short bursts.

然后发现长时间惊厥的小鼠所产生的神经群落较短期爆发惊厥的小鼠多。

Methods The effects of Wuweizi Ningshen Oral Liquid on sedation,hypnotics and anti-convulsion in mice were observed by counting spontaneous behavior,prolonging sleeping time cooperated with pentobarbital sodium and antagonizing convulsion induced by Nikethamide injection.

采用镇静、催眠、抗惊厥实验观察五味子宁神口服液对小鼠自主活动的影响，协同戊巴比妥钠对小鼠的催眠作用及对小鼠尼可刹米惊厥的抑制作用。

MethodsThe effects of Wuweizi Ningshen Oral Liquid on sedation,hypnotics and anti-convulsion in mice were observed by counting spontaneous behavior,prolonging sleeping time cooperated with pentobarbital sodium and antagonizing convulsion induced by Nikethamide injection.

方法采用镇静、催眠、抗惊厥实验观察五味子宁神口服液对小鼠自主活动的影响，协同戊巴比妥钠对小鼠的催眠作用及对小鼠尼可刹米惊厥的抑制作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。