惊厥

Objective To observe the effect of acrous g ramineus and its main component α-asarone on eclamptic behaviors and frontal lobe discharge in the young rats with experimental epilepsy induced by pentylenetetrazol.

目的：观察中药石菖蒲及其主要成分α-细辛醚对戊四氮诱发的实验性癫痫幼鼠惊厥行为和额叶皮层放电的影响。

Objective To find out the relationship between the periaqueductal gray and the audiogenic seizures.

目的 探讨中脑导水管周围灰质与听源性惊厥的关系。

Objective To find out the changes of synaptic density in the periaqueductalgray of the naive and kindled audiogenic seizures-prone rats.

目的 分析正常及点燃后听源性惊厥易感大鼠中脑导水管周围灰质内突触密度的变化情况。

The COD value in the dorsal and dorsolateral subdivisions of the PAG in the kindled audiogenic seizures-prone rats were significantly higher than that in the naive audiogenc seizures-prone rats.

用光镜观察PAG各节段各亚区切片上突触密度的变化，以期在光镜水平上了解PAG在惊厥状态下超微结构的某些变化。

Results The value of corrected optical density of the synaptophysin P38 immunoreactivity in the PAG of the naive and kindled audiogenic seizures-prone rats were significantly higher than that of the normal Wistar rats.

据此，本实验以P38免疫细胞化学反应的强度为指标，间接地对听源性惊厥易感大鼠(P77PMC)中脑导水管周围灰质(periaqueductal gray， PAG)各亚区突触的分布情况进行了研究。

Methods The neuronalstaining method and the immunocytochemical method were used to identify the Fos-postive neurons in the PAG of the audiogenic seizures-prone rats(P77PMC) after audiogenic seizures.

用神经细胞染色和免疫细胞化学技术，观察听源性惊厥发作后易感大鼠(P77PMC)PAG内即早基因c-fos的表达情况。

The main peaks of the EEG power spectra were in delta and theta frequency range. In the stage of ethanol exposure, the rats exhibited much more act of attack than the control, the alpha waves of EEG decreased, while the delta waves increased. The EEG power spectra analysis showed the delta power increased and the theta power decreased. In the stage of ethanol withdrawal, the rats showed some withdrawal behaviors such as wet dog shakes, sniffing, groomingand tonic-clonic seizures for audiogenic stimulus. Spikes and spike-slow waves were found in the EEG. In power spectra analysis, the delta power decreased while the alpha and the theta power increased, the EEG frequency band moved to the high-frequency rang. These changes were found obviously on the sixth day and disappeared on the 1 Oth day after the ethanol was removed.

本研究发现：1、对照组大鼠行为无异常，伏核EEG以α节律为主，散在出现δ和θ节律；功率主峰在δ和θ频段范围，整个过程中未发现手术对伏核EEG及脑电功率谱有影响。2、在慢性饮酒过程中，大鼠攻击性行为增加，伏核 EEG的α节律明显减少，散在出现的高幅慢活动δ波逐渐增多，功率谱分析表明δ频段功率百分比明显增加，而θ频段功率百分比明显减少，总功率减少。3、停饮后，大鼠出现湿狗样抖动、打喷嚏等撤药综合症，并且高频声音刺激能引发惊厥；伏核EEG出现棘波和棘慢综合波，并持续增多，功率谱分析显示δ频段功率百分比 5 南京医科大学硕士学位论文逐渐减少，而0和以频段功率百分比逐渐增加，总功率增加。

Qingyangshenylycosides is a mixture of several related compounds derived from the root of a Traditional Chinese Medicine, Cynanchum Otophyllum. Pharmacological characterization of the compounds indicated that the drug had a significant antiepileptic and anticonvulsant activity on kindling, rat audiogenic seizures and ferrous sulfate-induced epilepsy.

青阳参总甙(Qingyangshenylycosides，QYS)是萝摩科鹅绒属植物青阳参根粉提取物，已有动物实验表明QYS对大鼠听源性惊厥(audiogenic seizure，AGS)发作、&点燃&效应以及硫酸亚铁诱导的癫痫发作具有明显的对抗作用，表现出显著的抗癫痫效应。

Convulsion was induced by intravenous strychnine 0.25 mgkg^(-1. Normal saline and the different dose of ketamine were intravenously administered, respectively. Mortality and duration of tonic state were observed. The EEG activity was monitored continuatively.

耳缘静脉注射士的宁0.25mgkg^(-1)制作惊厥模型，分别静脉注射氯胺酮或相应剂量的生理盐水，观察氯胺酮对家兔的死亡率和强直持续期的影响。

Objective To explore the changes and clinical significance of neuropeptide Y and neuron-specific enolase levels in children with convulsibility diseases.

目的 探讨神经肽Y和神经元特异性烯醇化酶在小儿惊厥性疾病中的水平变化及其临床意义。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。