惊厥

RESULTS: Of the 115 patients, 71 ( 61.7%) had intracranial hemorrhage and 44 ( 38.3%) showed cerebral parenchyma lesions; 64 ( 55.6%) had high risk factors associated with brain damages; 34 ( 29.6%) had abnormal neurological signs: convulsion, hypertonia or irritability.

结果：115例存在胎儿期脑损伤的患儿中，不同部位颅内出血71例(61.7%)，双侧脑半球实质性病变44例(38.3%)。64例(55.6%)存在妊娠期多种合并症，34例(29.6%)新生儿期表现出惊厥、肌张力异常或激惹状态。

It indicated that a derivative of γ-aminobutyric acid with an imine link to a lipophilic carrier may have useful anticonvulsant activity.

通过亚胺键将一个亲脂性载体接到γ-氨基丁酸上制成的衍生物可能具有抗惊厥活性。

Seizure model of rats were induced by inhalant flurothyl daily in 6 consecutive days.

通过三氟乙醚反复吸入（连续6次，每天1次）制作发育期大鼠惊厥动物模型。

The dose-response curve of histamine was shifted parallely to the right. pA2 was 9.34±0.61. The guinea-pigs were effectively reduced the rate of histamine induced death, decreased reaction extent of shock (P＜0.01) and prolonged latency period of shock (P＜0.05) by orally administered cetirizine ranged from 0.1, 0.2 and 0.4 mg.kg-1. The capillary permeability to intracutaneous injection of histamine was potently inhibited by orally administered cetirizine ranged from 0.0625 to 0.25 mg.kg-1 in mice, blue area obviously decreased (P＜0.01), and dose-response curve existed obviously. In which the effect of these dosage groups were superior to the group of chlorphenamine.

结果：西替利嗪3×10-8～3×10-7mol.L-1可剂量依赖性地对抗组胺引起的肠肌收缩，使组胺的量效曲线平行右移，pA2为9.34 ± s 0.61，西替利嗪0.1，0.2及0.4 mg.kg-1口服给药时，能明显减轻豚鼠静脉注射组胺所致休克反应的严重程度(P＜0.01)，并可延长豚鼠惊厥反应的潜伏期及降低死亡率(P＜0.05)，西替利嗪0.0625～0.25 mg.kg-1口服给药可显著对抗组胺引起的小鼠皮肤血管通透性的增高，使蓝染面积显著缩小(P＜0.01)，且存在明显的量效关系，3个剂量组的作用均优于氯苯那敏组。

In order to clarify further molecular pathological mechanisms of epilepsy induced by coriaria lactone.

NMDA受体与惊厥和癫疒易感性的形成密切相关。

At the beginning, the domestic and external scholars studied it on the cattle, rat, lapin, fish , pig and cat etc , the result showed that the physiological effect of Coriaria lactone was similar to that of picrotoxinin , which effected nerve system , made the muscle and respiration exited and the vascular contracted , animated the heart restraint center so lead to the animal coma , startle , spasm etc symptom .

人们很早就认识到了它的毒性，最初国内外学者分别在牛、鼠、兔、蛙、鱼、猪和猫等动物上研究证明，马桑毒素的生理效应与苦毒素的生理效应极其相似，是通过作用于神经系统，产生肌肉兴奋，呼吸亢奋，血管收缩，激活心动抑制中心等从而导致抽搐、昏迷、惊厥、癫痫等症状。

The present study determined the effect of laudanosine on the minimum alveolar concentration of halothane and the influence of different inhaled anesthetics on the plasma concentration-seizure effect relationship for laudanosine in rabbits.

本文研究了Laudanosine在家兔中的药物代谢动力学及其对家兔氟烷MAC的影响，观察了几种常用吸入麻醉剂对家兔Laudanosine致惊厥血浆阈浓度的影响。

To determine the effect of anesthetic agents on the plasma concentration of laudanosine that produces seizure activity, the author administered laudanosine by i. v. infusion to rabbits with 7 different regimens.

家兔按Wagner氏双速率法静脉点滴Laudanosine溶液使血浆浓度达200，400，800ng/ml左右时，其氟烷MAC较对照（1.08±0.28%）分别增高8，22和30%左右，但无惊厥体征或脑电变化出现。

Over supply and high partial pressure of oxygen can bring about toxicity effect on neurons.

在过高的氧压下，高压氧作为一种神经毒性因子发挥作用，可导致惊厥。

The control group were treated with phenobarbital,while the observation group were treated with the phenobarbital and diazepam.

对两组治疗效果和并发症进行比较目的探讨苯巴比妥联合地西泮治疗小儿惊厥的效果。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。