惊厥

RESULTS: Both two recipes showed potent antifebril,anticonvulsive and sedative effects.

采用酵母引起的大鼠发热模型、伤寒副伤寒疫苗引起的兔发热模型、士的宁致小鼠惊厥及电惊厥模型等观察了2种配方的解热、抗惊厥和镇静作用。

The effect of different dose of lidocaine on conclusion duration and c-fos expression in brain with different doses.Forty mice were divided into 4 groups with 10 rates in each group who received 0, 30％, 60％ and 90％ convulsant doses of lidocaine intraperitoneally.

不同剂量利多卡因对小鼠惊厥时间和大脑c-Fos表达的影响：选择40只小鼠，随机分成4组：空白对照组、30％致惊厥剂量组、60％致惊厥剂量组、90％致惊厥剂量组，10只/组。

Result: Both doses of SAE and verapamil ig all raised the convulsant threshold of phenytoin-resistant rats (480.38±18.48)μA, there were statistical differences ( P .05) compared to themselves before drugs-treated.

结果：全蝎乙醇提取物2种剂量及维拉帕米，均可使耐苯妥英钠大鼠惊厥阈值(480.38±18.48)μA明显升高，与惊厥模型组和耐苯妥英钠惊厥模型组相比均有显著性差异( P 。01)。

Methods Three doses of etomidate were administered intraperitoneally. Five minutcs later, convulsion was induced by electricity or drugs . The convulsant latency, duration of tonic state, incidence of convulsion, mortality and survival time were noted.

以电刺激或致惊剂〔士的宁、N-甲基－D-天冬氨酸、利多卡因〕建立不同类型的小鼠惊厥模型，观察腹腔注射3种剂量的依托咪酯对小鼠强直性惊厥潜伏期、持续期、惊厥发生率、小鼠死亡率以及小鼠存活时间的影响。

Methods Three doses of etomidate were administered intraperitoneally.Five minutcs later,convulsion was induced by electricity or drugs ［strychnine.N-methyl-D-aspartate.lidocanine］.The convulsant latency,duration of tonic state,incidence of con-vulsion,mortality and survival time were noted.

以电刺激或致惊剂〔士的宁、N-甲基-D-天冬氨酸、利多卡因〕建立不同类型的小鼠惊厥模型，观察腹腔注射3种剂量的依托咪酯对小鼠强直性惊厥潜伏期、持续期、惊厥发生率、小鼠死亡率以及小鼠存活时间的影响。

MethodsⅠMaximal electroshock seizure was adopted to analyse the relative of dose and effect, relative of time and effect, including maximal efficacy and potency of these five extractives in mice given by ig administration.ⅡMetrazol seizure test was used to compare seizure latency, anticonvulsant rate and mortality of mice with every extractives.ⅢPharmacodynamic parameters of five alcoholic extractives were assayed by means of Pharmacological Effective Method.ⅣUsing the model of seizure rats induced by penicillin localized injected in cortex,we studied the effect of extractives on seizure latency, frequency of epileptiform discharge, highest wave of hippocampus EEG(Recoded by RM6240C multichannel physiological signal collection and analysis recorde), the changes of convulsant behaviors and the latency of seizure.

方法①采用最大电休克惊厥模型，分析灌胃小鼠各药的量效和时效关系，比较其效价强度和效能；②采用戊四唑惊厥模型，比较ig小鼠各药的惊厥潜伏期、抗惊厥率和死亡率；③采用药效法，运用数学模式及参数来模拟各药在体内的药效动力学过程；④制备大鼠皮层定位注射青霉素点燃模型，采用RM6240C型多道生理信号采集处理系统记录脑电图，比较ig各药对痫性发作潜伏期及发作程度、痫性放电潜伏期、痫波发放频率及最高波幅的影响；⑤采用HPLC法测定海马区癫痫相关递质的含量，比较各药对Glu、Asp、Gly、GABA的影响。

The ictal group included infants with typical clinical behaviors and/or with electrographic seizures, and nonictal group included infants without electrographic seizures and without clinical behaviors.

研究对象为42例急性脑病新生儿，以有无临床典型惊厥发作和/或脑电图出现放电活动分为惊厥组、无惊厥组。

Although the clinical experience and the results of animal experiments indicate that the adminis- tration of atracurium at recommended doese is unlikely to result in laudanosine concentrations capable of producing seizure activity, Hennis et al found that at a plasma concentration below that causing convulsions, laudanosine "awaken"dogs lightly anesthetized with halothane.

临床病人应用常用剂量阿屈宁后，血浆Laudanosine选低于使动物发生惊厥所需的浓度，数百万例应用阿屈宁的病人中也未见有因代谢生成之Laudanosine而发生惊厥体征或脑电征象者。可以认为，阿屈宁的临床应用是不会因Laudanosine的生成而引起惊厥的。

IL-1βmRNA expression in the developmental brain in Wistar rat: IL-1β mRNA in hippocampus, cerebral cortex and subcortex was detected by postnatal day 1 and gradually increased with development, reached a peak at postnatal day 21, and then gradually decreased to lower level at adult; In P77PMC rat, IL-1β mRNA expression was similar to Wistar rat before postnatal day 14, then gradually increased and surpassed Wistar rat at postnatal day 28, reached a peak in adult.

原位杂交显示谷氨酸诱导Wistar大鼠惊厥和P77PMC大鼠听源性惊厥后脑内IL-1βmRNA表达情况。结果发现，两种不同惊厥模型大鼠惊厥后脑内IL-1βmRNA表达存在明显的差异。谷氨酸引起惊厥诱导脑内皮层、海马和丘脑IL-1βmRNA表达增高的程度远较P77PMC大鼠听源性惊厥为低，而且惊厥后IL-1βmRNA表达增加较慢，于4-8h达高峰，而听源性惊厥可于惊厥后2h迅速达高峰。但两种形式惊厥诱导脑内IL-1βmRNA表达最高的部位均是海马。

Methods Sample dosages were used 15mg,20mg,25mg/ by gstro gavage.The conrulsion rates was induced by maximum electric shock,ip cardiazin mice and lateral intracereral injection of curine in rats were observed.

方法采用克癫胶囊251、5、20mg/灌胃给药，观察最大电休克致小鼠惊厥率和筒箭毒碱侧脑室注射致大鼠惊厥率及戊四唑诱发小鼠惊厥的抗惊厥作用。

The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应，而且减少跟风的可能性。