患病期

Objective To investigate the clinical features, causes of blindness and diagnosis of Vogt Koyanagi Harada syndrome Methods The data of 157 patients with VKH syndrome were reviewed and analyzed Patients were carefully examined with slit lamp, ophthalmoscope, three mirror lens, fundus fluorescein angiography, indocyanine green angiography and HLA typing Results Headache was noted in 73 5% of these patients Simultaneous involvement of both eyes occurred in 80 8% of these patients Chroiditis,papilledema and edema of the retina adjacent to the optic nerve were noted in 100% of these patients in the posterior uveitis stage, whereas recurrent granulomatous anterior uveitis (98 4%),"sunset glow" fundus (95 8%) and Dalen Fuchs nodules (71 2%) were the common ocular findings in the recurrent anterior uveitis stage The common causes of blindness were papillitis, exudative retinal detachment and complicated cataract in the posterior uveitis stage, anterior uveal involvement stage and its recurrent stage Poliosis (36 3%) and alopecia (35 0%) were the most common extraocular findings Early irregular patches of fluorescence, followed by localized hyperfluorescent spots were the typical findings of FFA Dilation of choroidal vessels and leakage of ICG from the choroidal vessels were the common ICGA findings The prevalence of HLA DR4 and HLA DRw53 in patients (54 9% and 71 8% respectively) was significantly higher than that in controls (14 7% and 38 2% respectively) Conclusions VKH syndrome is characterized by chroiditis, papillitis or neuroretinitis in the posterior uveitis stage, followed by a generalized uveitis with a typical recurrent granulomatous anterior uveitis Extraocular findings and relevant examinations including FFA, ICGA and HLA typing are helpful to the diagnosis of VKH syndrome

目的探讨Vogt-Koyanagi-Harada综合征患者的临床特征、盲目原因及诊断等有关问题。方法对在1996年1月至2000年12月间就诊资料完整的157例VKH综合征患者进行回顾性分析，并对裂隙灯、眼底镜、三面镜、荧光素眼底血管造影(fundus fluorescein angiography，FFA)、吲哚青绿血管造影(indocyanine green angiography，ICGA)及人类白细胞抗原分型等检查结果进行分析。结果 VKH综合征最常见的前驱症状为头痛(102例，73.5%)，双眼同时患病118例(80.8%)；后葡萄膜炎期眼部主要表现为脉络膜炎、视乳头及附近视网膜水肿(100.0%)；前葡萄膜炎反复发作期眼部表现为复发性肉芽肿性前葡萄膜炎(128例，98.4%)、晚霞状眼底改变(95.8%)及Dalen-Fuchs结节(71.2%)；后葡萄膜炎期、前葡萄膜受累期及前葡萄膜炎反复发作期导致盲目的主要原因分别为视乳头炎、视网膜脱离及并发性白内障；毛发变白(36.3%)及脱发(35.0%)是最常见的眼外表现；炎症活动期FFA典型表现为斑驳状高荧光，ICGA发现脉络膜血管扩张、通透性增高等改变；VKH综合征患者HLA-DR4及HLA-DRw53的阳性率(54.9%及71.8%)显著高于正常对照组(14.7%及38.2%)。结论 VKH综合征患者在后葡萄膜炎期眼部典型表现为双侧脉络膜炎、视乳头炎或神经视网膜炎，随后出现以反复发作的肉芽肿性前葡萄膜炎为特征的全葡萄膜炎。眼外症状及相关的辅助检查包括FFA、ICGA 及HLA分型等有助于VKH综合征的诊断。

Results In this pedigree,there are 1 3 people showed typical AI S symptoms,8 died of this disease,but most of them present varing period of fasciculation before onset.

结果：该家系有6代、237人，其中1 3人患病，8人死于AI s，具典型ALS症状，但起病前有较长一段时间肌肉纤颤期。

Results In this pedigree,there are 13 people showed typical ALS symptoms,8 died of this disease,but most of them present varing period of fasciculation before onset.

结果该家系有6代、237人，其中13人患病，8人死于ALS，具典型ALS症状，但起病前有较长一段时间肌肉纤颤期。PCR-SSCP法检测SOD1基因未发现突变，为非SOD1基因突变的ALS家系。

ABSTRACT Objective: IgA nephrosis is one of the most common pathologic types of primary glomerular diseases, there are about 50% p...

目的： IgA肾病是原发性肾小球疾病中最常见的病理类型之一，约有50％的患者在患病20年后进行性发展至终末期肾衰竭。

ABSTRACT Objective: IgA nephrosis is one of the most common pathologic types of primary glomerular diseases, there are about 50% patients with IgAN going to the end stage renal failure.

目的： IgA肾病是原发性肾小球疾病中最常见的病理类型之一，约有50％的患者在患病20年后进行性发展至终末期肾衰竭。

Results: 1. Childhood trauma history: the patients with BPD had significantly higher scores of emotional abuse, physical abuse, sex abuse, emotional neglect and physical neglect than the non-personality disorder patients. 2. The parental rearing style: comparing with the Chinese norm, the scores of emotional warmth / comprehension of BPD group were lower; the scores of punishment/rigorousness and rejection /deny of BPD group were higher; The differences were significant. 3. Family environment: comparing with Chinese norm, the scores of intimacy/ affection expression/ independence/ success/ culture/ entertainment/ morality and religion/sense of organization of BPD group were lower; the scores of contradictory were higher.4. Correlation analysis revealed that the childhood trauma history of BPD was correlated with the unhealthy parents' rearing style and family environment. 5. Logistic regression analyses revealed that gender, emotional abuse, physical abuse, emotional neglect are the risk factors for BPD.

结果1、BPD儿童期创伤经历：BPD患者在情感虐待、躯体虐待、性虐待、情感忽视、躯体忽视及总体虐待程度显著高于精神科门诊中非人格障碍患者。2、 BPD父母养育方式：BPD患者的父母养育方式与中国常模相比存在较多显著差异，父亲在情感温暖理解、过度保护方面远低于对照，而在惩罚、严厉，拒绝、否认方面远高于对照；母亲在情感温暖、理解方面远低于对照，而在拒绝、否认，惩罚、严厉方面远高于对照。3、 BPD家庭环境：患者家庭的亲密度、情感表达、独立性、成功性、文化性、娱乐性、道德宗教观、组织性等方面均显著低于中国常模；而矛盾性方面显著高于常模。4、 BPD儿童期创伤与不恰当的父母养育方式和不良的家庭环境显著相关。5、BPD的影响因素：经Logistic回归分析，性别、年龄，情感虐待、躯体虐待、情感忽视是影响BPD患病与否的关键因素。

Case 3, uremic patients JIANG Jing Gang, male, 26 years old, Jintang County of Chengdu City in Sichuan Province and Technical Supervision cadres, he is sick of the news center in the "Understanding" magazine in May 2002 on the semimonthly period,"thought his brother Oliver back, tied with his brother ill shore where entangled" The article on that, in their contacts with the patients have been in the General Hospital of Chengdu Military Region of the last two months and more hemodialysis treatment, but returned home service medicine, there has been more than mouth the risk of hemorrhage, relatives of patients with the Center should request that since May 13, 2002 sent by train from Qingdao arrived home patients using onboard eternal secret Chinese medicine, and patients and their families in the village under suspicion, were completed in two days time, so patients with mouth and nose bleeding more than the danger of the stop, not bleeding, it is no longer need to do hemodialysis, and the medical miracle that I am afraid people will only see personally believe.

病例3，尿毒症患者蒋某某，男，26岁，四川省成都市金堂县某局的干部，他患病的消息是本中心在《知音》杂志2002年5月期上半月刊"仗义哥哥苦海回头，苦命弟弟绝症缠身何处有岸"的文章上得知的，在与他们的联系中，患者已经在成都军区总医院治疗血透了二个多月，后来回家服中药，出现了口鼻出血不止的危症，本中心应患者亲属请求，自2002年5月13日派人从青岛乘火车赶到患者家中，用自带的千古秘方中药，在患者及其家人和全村的怀疑下，仅用了2天的时间，就把患者口鼻出血不止的危症止住了，不出血了，也无需再去做血透了，这样的医疗奇迹恐怕只有亲眼所见才会有人相信。

The study included patients aged 30 and older who had a diagnosis of idiopathic PD of less than or equal to 5 years in duration, a baseline UPDRS Motor Function examination score of at least 10, a Hoehn and Yahr stage score less than or equal to 3, and 2 or more cardinal signs of PD, including bradykinesia, resting tremor, rigidity, or postural instability.

该实验患者为30岁及30岁以上诊断为突发性帕金森病患病5年或5年以下者，其UPDRS运动评分至少为10，按帕金森病hoehn - Yahr 分级标准至少3期，有2项或2项以上帕金森病主要症状，包括行动迟缓、静止性震颤、肌僵直、或姿势不稳定。

Nosema disease is a kind of zoonoses, of all ages can be affected by pollution, for human carinii infection and host immune function of severely inhibited closely related to people before that Nosema without sexual reproduction period .

微孢子虫病是一种人兽共患病，各年龄组均可受染，人类为孢子虫感染与宿主的免疫功能严重地受到抑制有密切关系，以前人们认为微孢子虫无有性生殖期。

Everyone is going to die, either when one is too old or becomes ill or has a disaster when still young. Sooner or later, one has to deal with a longer or shorter thanatological period of time, and also experience some degree of pain while dying.

既然人人皆会死，无论是正常老死或是患病罹祸而早夭，因此每个人都迟早会面临一段或长或短的临终期，也必然要经历或深或浅之临终前的痛苦。

In the United States, chronic alcoholism and hepatitis C are the most common ones.

在美国，慢性酒精中毒，肝炎是最常见的。

If you have any questions, you can contact me anytime.

如果有任何问题，你可以随时联系我。