患...病

Asked by Medscape Oncology to comment on this finding, Jayne Franklyn, MD, PhD, from Queen Elizabeth Hospital, in Birmingham, United Kingdom, who was not involved with the study, said: \"This is an important study, as it involved a large number of patients with a relatively rare form of thyroid cancer, specifically looking at those with the sporadic or noninherited variety of this cancer, and it presents the intriguing possibility that the presence of the mutation is associated with a prediction of tumor behavior and therefore prognosis.\"

Medscape肿瘤学邀请英国伊丽莎白皇后医院的Jayne Franklyn医师对此发现进行评论，未参与此研究的Franklyn医师表示，这是一个重要的研究，因為它纳入了此一少见甲状腺癌的许多病患，特别是此癌症的偶发或者非遗传变化，且展现出突变与预后有关的可能性；此外，该研究有潜在的临床冲击，但是首先，这些发现需要有其他研究证实重现；这项研究也指出各种甲状腺癌的基因突变与基因表现可提供预后资讯的远景。

The survey sample size are 5,284, after excluded noninsurance ,age under20 years old and professional military personnel ; our final sample include 3,288,and there are 1,151 chronic disease patients.After controlling for need factors eg.

其中问卷调查之完访人数为5，284人，最后纳入年龄20岁以上己纳保之受访者，以及由於职业军人之身份较为特殊，不将其列为本次研究范围内，因此最后之样本数为3，288人，其中罹患慢性疾病之人数为1151，其罹病率为21.7%。

Elisabetta Bugianesi, MD, PhD, who was not involved in the study, agrees that nonalcoholic fatty liver disease in particular is an important clinical entity that can be difficult to identify."NAFLD constitutes a special challenge for physicians for several reasons: any distinction between nonprogressive and progressive disease is only based on liver histology, but NAFLD patients are generally asymptomatic invasive procedures are not easy to propose to accept," she told Medscape via email.

未参与此项研究的Elisabetta Bugianesi医师同意非酒精性脂肪肝病是重要的临床表徵，但是却不易鉴别诊断；她以电子邮件向Medscape表示，NAFLD对医师们构成一个特别的挑战，因为在非进行性和进行性的疾病之间的差别，仅可从肝脏组织判断，但是NAFLD病患一般是没有症状的，所以对於侵入式的诊断方式难以接受。

In nonsmokers without pulmonary disease at baseline, there were no severe decreases in lung function attributed to Exubera, and high-resolution chest computed tomography revealed no evidence of notable lung changes. Completed phase 2 and 3 studies that followed patients for up to 4 years indicate that the differences over time in pulmonary function changes between patients treated with Exubera and control patients are small, nonprogressive, clinically insignificant, and reverse after discontinuation of Exubera therapy.

Feb。 9， 2006 --尽管一开始对於肺功能影响的顾虑，美国食品药物管理局仍然批准辉瑞药厂生产的吸入性胰岛素Exubera使用於成人第1、2型糖尿病；该核准案於1月27日通过，也就是欧盟核准该药物上市后隔天；自从胰岛素於1920年代被发现以来，吸入型粉状的基因重组人类胰岛素是第一个新的胰岛素投与选择；临床试验数据显示，使用exubera一开始会使肺功能下降，但是并非进行性的，其效果与一般胰岛素相当，而且具有病患顺从性较高的优点。

The result shows that the relationship between patient and religious hospital is stronger than than that the relationship between patient and nonreligious hospital. Therefore, we can infer that the attribute will affect relationship quality and revisit intent.

研究结果发现，宗教型医院的相关联结性大致上比非宗教型医院的相关联结性强，所以可以推论医院的成立组织属性会影响病患就诊的相关品质及感受。

We rearranged the patients into two subgroups by patients participated in the clinical trials or not, Trial group and Nontrial group.

再依照病患是否曾参与第一线合并化疗临床试验分组；一年存活率临床试验组 vs。

The average six-month cumulative treatment cost was 10.6% lower for Trial patients than Nontrial patients 306,892NTD vs.

两组病患从开始化疗药物治疗至之后半年、一年、两年、终身的累积费用分别为：半年累积总费用试验组比非试验组低10.6% 306，892元vs。

The treatment regimens of Trial patients who were randomized into control group (Trial-control group) were quite the same with the standard treatments of Nontrial group. There was no significant difference in median survival between Trial-control group and Nontrial group. The median survival of Trial group patients who were randomized into trial group was significantly longer than that of Nontrial group patients.

在Phase III的临床试验中，病患会被随机分派到试验组(Trial-trial)或是控制组(Trial-control)，控制组的治疗方式与非临床试验组类似，两组存活时间在统计上没有差异；使用新药或新疗程的Trial-trial组的存活时间比非试验组显著较长。2000-2003年间存活时间有较长的趋势，而医疗成本部分则是2004年比起2000年显著的升高。

Trial group incurred more outpatient costs and Nontrial group incurred more inpatient costs. Patients' median survival, receiving second line chemotherapy treatment, radiotherapy, surgery, patients with heart disease and those who received free drug while participating in clinical trials were all significant predictors of treatment costs.

分析影响病患医疗费用的因子，较长的存活时间、接受第二线以上化疗、接受放疗、接受手术、有心脏疾病等因子会显著增加费用，而参与由厂商提供免费新药的试验则会显著的使医疗费用减少。

Hauled stark over the gunwale he breathes upward the stench of his green grave, his leprous nosehole snoring to the sun.

隔着船帮硬被拽上来的尸首，散发出绿色坟墓似的恶臭。他那患麻风病般的鼻孔朝太阳喷着气。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。