恶性胶质瘤

The level of ADAR gene expression was expressed as ratio expression rate of ADAR gene /β-actin acc...

ADAR3在正常人脑胶质细胞及苯乙酸处理前后的胶质瘤细胞中，均未见表达。结论ADAR2 mRNA水平高表达，可能与高恶性度胶质瘤的发生有关。

Objective To test the expression of Cathepsin B protease in gliomas and to investigate its correlation with the malignance and angiogenesis of gliomas.

目的 探讨组织蛋白酶B在人胶质瘤中的表达及其与胶质瘤恶性程度、血管生成的关系。

The purpose of this study was to investigate the CDK1 expression levels in gliomas and the effects of CDK1 knockdown on phenotype of glioma cells.

目的探讨周期蛋白依赖性激酶1（CDK1）在胶质瘤组织中的表达及其沉默对胶质瘤细胞恶性表型的影响。

We found that malignant human glioma cells constitutively expressed matrix metalloproteinase-2 (MMP-2), and the MMP-2 activities were correlated well with their malignancies.

我们发现恶性人类神经胶质瘤细胞会持续的表现matrix metalloproteninases-2 (MMP-2)，而且MMP-2的活性和肿瘤细胞的恶性度有密切的关系。

Results among 34 cases of orbital tumor,29 cases were with benign tumor, 5 cases of malignant tumor, 8 cases of hemangioma,5 cases of dermoid,5 cases of inflammatory pseudotumor,3 cases of liparomphalus,3 cases of haematoma,3 cases of mixed tumor of lacrimal gland,2 cases of optic nerve glioma, 2 cases of cancerometastasis,2 cases of adenocarcinoma,1 cases of malignant lymphoma.

结果 34例眼眶肿块患者中，良性肿块29例，恶性肿瘤5例；其中血管瘤8例，皮样囊肿5例，炎性假瘤5例，脂肪瘤3例，泪腺混合瘤3例，血肿3例，视神经胶质瘤2例，腺癌2例，转移性癌2例，恶性淋巴瘤1例。

RESULTS A variable degree of vascular hyalinization and glioma intercellular with enhanced tenascin immunostaining was observed.Expression of tenascin and cell proliferation in gliomas correlated positively with each other and increased with the degree of tumor malignancy.

结果 胶质瘤与其增生血管内皮细胞均表达Tenascin，Tenascin基因表达与肿瘤细胞增殖指数呈显著正相关，随胶质瘤恶性程度提高，Tenascin和Ki-67表达均增强。

The malignant growth of neuroepithelial cell will result in glioma with high invasiveness and rapid growth.

神经胶质细胞的恶性生长导致胶质瘤，胶质瘤侵袭性强、生长迅速。

This research has proved that an artificial neural network is capable to differentiate the reactional enhancement of malignant intracranial gliomas in postoperative MR images and the enhancement caused by tumor residual. As a innovative differentiation approach, it requires further studies and researches to determine its applicability in practice, including the increase of training samples, image de脚本ion standardization, effects to doctoral diagnosis, as well as parameter optimization. With improvements in these elements, the performance of the network will be optimized.

本研究成功地证明了人工神经网络能够鉴别颅内恶性胶质瘤术后磁共振图像的反应性强化与肿瘤残存所致的强化，为解决二者的鉴别这一复杂问题提供了一个新的方法，但是本研究只是初步的应用探讨，能否在实际中应用，还有待于进一步的研究，如训练样本的增加、图像描述的规范化、对医师诊断影响程度、参数的优化等，网络的性能会不断完善和提高。

Neural stem cells have a strong self-renew mechanism and it can transform after a little break. Neural stem cells have a long term survival, which mean that it has more probability of wrong copy than mature cells. These cells are formed glioma stem cells in the end. The genes who adjust neural stem cells can express in glioma stem cells, which hold out glioma stem cells from neural stem cells. There is another presume that glioma stem cells come from differentiated cells. Through the gene break of these cells, they can obtain characteristics of stem cells, then form glioma stem cells.

神经干细胞具有很强的自我更新机制，获得较少突变即有可能恶性转化，而且干细胞存活时间较长，这意味着干细胞比成熟细胞发生细胞复制的错误几率更大，因外界环境的刺激而发生突变的机会更多，最终形成脑胶质瘤干细胞，同时调节神经干细胞增殖和自我更新的基因在脑胶质瘤的脑胶质瘤干细胞中也表达，这也是支持神经干细胞是脑胶质瘤干细胞来源的；也有推测认为它可能起源于已分化的细胞，由这些细胞突变发生去分化得来，并通过基因突变而获得了干细胞自我更新的特性，从而形成脑胶质瘤干细胞。

Malignant gliomas are more aggressive in older people. Ted Kennedy is seventy-six years old.

恶性胶质瘤对年长的人危害更大，K已经76岁了。

She gently rebuff ed him, but agreed that they could be friends

她婉言拒绝了，但同意作为朋友相处。

If in the penal farm, you were sure to be criticized.

要是在劳改农场，你等着挨绳子吧！