性异常

Abstract］ objective to study the pathological features and histopathological type and differential diagnosis of hepatic focal nodular hyperplasia.methods the clinicopathological characteristics of 40 cases of fnh were studied.all were evaluted by use of paraffin embedded sections and he staining before light microcope observation.results there were 28 females and 12 males fnh patients whose age were from 16 to 62 years（median 41.3）,all alpha-fetoprotein was negative and had no hepatitis history.25 cases were classic type showed characteristic central stellate fibrotic scar,composed of fibrous connestive tissue and tortuous blood vessels.8 cases were telangiectic type,the left were mixed type and adenomatoid type.conclusion fnh is a reactive proliferation of hepatic cells to local blood vessel anomalies,it is not realy a tumor.its differential diagnosis includes hepatic adenomatous hyperplasia nodule,hepatic anaplasia nodular hyperplasia,fibrolamellar hepatocellular carcinoma and hepatocellular adenoma.

目的 探讨肝局灶性结节性增生的病理形态特点、组织分型及鉴别诊断。方法分析40例肝局灶性结节性增生的临床资料，并采用石蜡包埋he染色光镜下观察其组织学特点。结果 40例肝局灶性结节性增生患者中，女28例，男12例，年龄18~62岁，平均年龄41.3岁，所有病例术前均无肝炎病史，甲胎蛋白阴性，组织学上25例为经典型，有特征性的中央纤维瘢痕，由纤维结缔组织及扭曲血管组成。8例为毛细血管扩张型，其余为混合型及腺瘤样增生型。结论肝结节性增生是一种肝细胞对局部血管的异常反应性增生，并非真性肿瘤，主要与肝腺瘤样增生性结节、肝间变性结节状增生、肝纤维板层癌及肝细胞腺瘤鉴别。

Objective: To report CT and/or MRI findings in five cases with adrenal gland sex characteristics abnormality, and to discuss the diagnostic value and limitation of CT and MRI for them combined with the documents.

目的：报告5例肾上腺性征异常病变的CT和／或MRI影像学表现，并结合文献讨论这两种影像检查方法对肾上腺性征异常病变的诊断价值和限度。

"Resulting disorders include Down's syndrome, mental retardation, heart malformation, abnormal sexual development, malignancies, and sex-chromosome disorders (e.g., Turner's syndrome, Klinefelter's syndrome)."

所导致的疾病包括唐氏症候群、精神发育迟缓、心脏畸形、性发育异常、恶性肿瘤和性染色体异常(如特纳氏症候群、克兰费尔特氏症候群)。

"Resulting disorders include Down's syndrome, mental retardation, heart malformation, abnormal sex ual development, malignancies, and sex -chromosome disorders (e.g., Turner's syndrome, Klinefelter's syndrome)."

所导致的疾病包括唐氏症候群、精神发育迟缓、心脏畸形、性发育异常、恶性肿瘤和性染色体异常(如特纳氏症候群、克兰费尔特氏症候群)。

This paper proposed a network connection based anomaly detection approach with unlabeled training data.

提出了一种基于无类标训练数据的异常检测方法，该：于法克服了传统异常检测需要纯净训练数据或有类标训练数据的限制，提高了异常检测的可用性。

Cases were the diseases with two or super-two kings of abnormity, including 25 cases' chronic obstructive pulmonary disease, 7 cases' pulmonary alveolar proteinosis and 5 cases' viral pneumonia. The DGGO had presented mosaic-fashion's shadow or geographic change or crazing paving pattern, or the DGGO had centrally distributed with lobular central node, acinose node and interstitial fibrosis. Conclusion DGGO may be seen in various diseases.

两种因素或两种以上因素异常的疾病有慢性阻塞性肺病25例、肺泡蛋白沉积症7例及病毒性肺炎5例，慢性阻塞性肺病为通气-血流障碍所致，其磨玻璃影与低密度区形成马赛克样改变，常伴有桶状胸；而肺泡蛋白沉积症及病毒性肺炎同时具有气腔和固有肺结构异常，其磨玻璃影是间质性病变与实质性病变共同作用的结果。

At the one-cell stage, each embryo was injected with gradient doses of 2-8ng MO. The control morpholino, was purchased from Gene-Tools.To test the knockdown effectiveness of the morpholino, the tbx2-EGFP (enhanced green fluorescent protein) construct was generated. And coinjection of morpholino with mRNA tests its specificity of the morpholino. Overexpression of tbx2 via mRNA microinjection helps us understand gaining function of tbx2. Results The tbx2-EGFP construct tests the knockdown effectiveness of the morpholino. Zebrafish embryos lacking tbx2 function have defects in cardiac contractility, rhythm and morphology in a dose-dependent manner. The embryos with c-MO are normal in development. Coinjection of morpholino with mRNA rescue the phenotype of tbx2 knocking down. The phenotypes include pericardial edema, hypogenetic ventricle, dilation of atria, arrhythmia, bradycardia, asystole, abnormal atrioventricular canal, aberrant valve and blood regurgitation.

结果荧光蛋白融合标记实验验证了tbx2-MO可以很好得阻抑斑马鱼胚胎tbx2的表达，tbx2-MO组胚胎在心脏收缩性、节律和形态学发生上出现了异常，心脏畸形随着注射剂量的增加而出现比较一致的表型，而c-MO组胚胎没有出现明显的畸形；tbx2-mRNA和tbx2-MO的共注射减少了tbx2-MO胚胎心脏畸形的发生率及减轻了心脏畸形的程度，验证了所设计合成的tbx2-MO对tbx2基因的抑制作用具有特异性；tbx2-MO组胚胎心脏缺陷包括心室发育不良、心房扩张、房室管和瓣膜异常以及心率缓慢、心律不齐、心脏停搏、血液返流等，并根据心脏发育异常的程度分为轻、中、重度畸形组tbx2-mRNA基因过表达胚胎没有见到心腔的形成。

Results All the children and their parents received interviews, otological examinations and clinical audiolugical teats. Their ages were between 4 and 15, with the average at 9.51±2.83.①The males were 341 (61.66%) and female 212 (38.34%), with the gender ratio of male to female as 1.61:1.②The peak of the age curves of treatment and the first onset of vertigo was 9.51 and 8.62-year-old, respectively.③20.98% of children with vertigo had normal results with peripheral vertigo more common in the rest.④ The semicircular canals were more likely to dysfunction if their relatives had vertigo or car sickness.

结果 ①553例儿童年龄4~15岁，平均9.51±2.83岁；男341例(61.66%)、女212例(38.34%)，男女之比为1.61：1；②就诊年龄和初次眩晕发病年龄的高峰期分别在9.51岁和8.62岁，发病无季节性，主要症状为自身或视物旋转，发作持续时间为数分钟至数小时；③约20.98%的儿童眩晕患者各项检查结果均正常，异常组中以外周性眩晕多见(78.04%， 341/437)，半规管功能异常者占63.83%(353/553)；④256例眩晕儿童直系家属中有眩晕史，其中171例(66.80%)出现水平半规管功能异常。

Part Ⅰ: Brain structural abnormalities in patients with a first episode of major depression — An Optimized Voxel-based morphonmetry MRI study OBJECTIVE: We examined the structural difference in regional gray matter density between unmedicated patients with a first episode of major depression and healthy comparison participants in order to find the base of pathophysiologic mechanism in MD.

第一部分首发重性抑郁症患者脑结构磁共振异常的研究—基于体素的优化形态测量学分析方法目的：探讨首发、未服药重性抑郁症患者全脑灰质密度的异常变化，以揭示抑郁症患者病理生理机制的脑结构基础。

His older brother suffers from cerebral palsy, a birth affliction whose motor functions had been permanently injured, leading to central movement disorders, and abnormal posture, often accompanied by a variety of other disabilities such as muscle symptoms of numbness, weakness, disorders, movement disorders.

哥哥患有大脑性瘫痪，即大脑在出生时已受到永久伤害，导致中枢性运动障碍及姿势异常，经常伴有其他多种残疾，症状是肌肉麻木、无力、失调、动作异常等。

However, as the name（read－only memory）implies, CD disks cannot be written onorchanged in any way.

然而，正如其名字所指出的那样，CD盘不能写，也不能用任何方式改变其内容。

Galvanizes steel pallet is mainly export which suits standard packing of European Union, the North America. galvanizes steel pallet is suitable to heavy rack. Pallet surface can design plate type, corrugated and the gap form, satisfies the different requirements.

镀锌钢托盘多用于出口，替代木托盘，免薰蒸，符合欧盟、北美各国对出口货物包装材料的法令要求；喷涂钢托盘适用于重载上货架之用，托盘表面根据需要制作成平板状、波纹状及间隔形式，满足不同的使用要求。