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性功能障碍

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Results Primary clinical manifestation of 9 patients were abulia,behavior disorders,thalamic aphasia,left spatial neglect,visual space function disorders,memory disorders.

结果9例患者主要临床表现为:意志缺乏和行为障碍、丘脑性失语和左侧空间忽视及视空间功能障碍、记忆障碍,而均无脑神经损害及运动、感觉障碍。

Methods Re-operations were done in235cases with recurrent cardiac valve diseases from1985to2003.Aˉmong these patients,155cases had received closed mitral commissurotomy,12with mitral valvuloplasty,43with biologˉical prosthetic failure,6with mechanical prosthetic dysfuction,6with periprosthetic leakage,2with prosthetic valve enˉdocarditis,8with other valve disease after valve replacement,1with closed mitral commissurotomy and redo MVR,redo DVR,1with closed mitral commissurotomy and redo MVR,redo MVRand redo AVR.6cases received TVR and179with tricuspid valvuloplasty.

1985年1月~2003年9月,235例复发性心脏瓣膜病再次手术,其中二尖瓣闭式分离术后155例,二尖瓣直视成形术后12例,生物瓣衰43例,机械瓣功能障碍6例,瓣周漏6例,机械瓣心内膜炎2例,换瓣后其它瓣膜病8例,1例闭式分离术后MVR后瓣膜障碍再次DVR,1例闭式术后MVR后瓣衰再次MVR后再行AVR,1例MVR后AVR后TVR。

Domenstic and abroad academicians have disclosed the influence mechanism of these factors from different aspects, including the gene polymorphism and gene mutation in genetics, which are a susceptible factor for cardiovascular complication in type 2 diabetes patients; the dysfunction of endotheliocyte, the metabolic disorder of lipid, and dysfunction of vascular smooth muscle, which can lead to the formation of arteriosclerosis;the formation of immune complex,which can also accelerate the destruction of artery paries;the sctivation of protein kinase C and the dysfunction of platelet, which may ultimately result in the formation of thrombus and influence the function of cadiac muscle cells.

其中主要包括:遗传学方面的基因多态性和基因突变,二者均是2型糖尿病合并心血管疾病的一个易感因素,内皮细胞功能障碍、脂质代谢异常及血管平滑肌细胞功能异常均可导致动脉粥样硬化的形成;免疫复合物的形成可加速动脉壁的破坏;蛋白激酶C的激活及血小板功能受损最终导致血栓形成并影响心肌细胞的功能。

Compared with the previous experiment model, this model which adopts the pressure Saccule to create gradually the pressure on the cervical spinal cord has its own advantages as follows: simple to operate, safe to carry out, successful rate is higher; cheaper catheter to obtain, oppressing the machine creation the convenience; to achieve the purpose that gradually pressure on the ventral lateral spinal cord, the medical screenage and electric physical examination reflect accurately the degree of the chronic pressure on the spinal cord; the change of Pathologic histology with the impediment on spinal cord function is similar to in the characteristic changes that of human CSM. ideally simulated the pathological procedure of the gradual chronic pressure in the course of the breakout of the CSM.

与既往实验模型比较,此模型采用压力球囊法致慢性颈脊髓压迫具有以下优点:手术操作简单易行,安全性及成功率较高;导管廉价,压迫器制作方便;达到了渐进性压迫的目的;影像学及电生理检测比较准确地反映了慢性颈脊髓压迫的程度;脊髓功能障碍后脊髓病理组织学改变类似于人类脊髓型颈椎病的特征性改变;较理想地模拟CSM发病中的慢性渐进性压迫的病理过程。

BACKGROUND: Reactive depression and depressive neurosis are both psychogenic emotional disorders, clinically manifested by memory deterioration,impaired concentration, slow reaction, and bradyphrenia, among other cognitive function impairments.

背景:反应性抑郁症和抑郁性神经症为心因性情绪障碍,临床上均有记忆力减退、注意力不集中、反应迟钝、思维迟钝等认知功能损害的主诉,患者这种主观体验是否属实,对这类疾病认知功能损害客观的实验室的依据较少。

Results The clinical manifestations of TOBS comprised transient unconsciousness, vertigo, dyskinesia of eyeball, abnormality of pupils, dyskinesia of limbs, hemianopsia or cortical blindness, ataxia and memory impairment. MRI showed the local infarction in thalami, cerebellum, midbrain, pons, occipital lobe, temporal inner surface. The features of DSA were occlusion or stenosis in basilar artery and vertebral artery.

结果 TOBS的临床主要表现为一过性意识障碍、眩晕、眼球运动障碍及瞳孔的变化、肢体运动障碍、偏盲或皮质盲、共济失调及记忆功能损害;磁共振显示梗死灶在丘脑、小脑、中脑、脑桥、枕叶、颞叶内侧面;数字减影血管造影显示为基底动脉及椎动脉闭塞或狭窄。

Under the same concentration, tadalafil induce higher ratio of relation responses in the smooth muscles of CRF rabbit cavernosal strips, compared with papaverine and sodium nitroprussiate, with most significant difference occurring under the concentration indicators of 10-5 mol/L and 10-4 mol/L (P.01). Conclusions The effects of tadalafil on relaxation responses in CRF rabbit cavernosal strips highly depend on its concentration. The effect of tadalafil on relaxation responses in CRF rabbit cavernosal strips is better than that of papaverine and sodium nitroprussiate. Tadalafil may be an effective drug for treating CRF reduced erection dysfunction.

同一浓度下,他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张百分比与罂粟碱、硝普钠相比较,舒张百分比均大于罂粟碱和硝普钠,且在10~(-5)mol/L、10~(-4)mol/L浓度,他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张百分比,与罂粟碱、硝普钠相比较有显著性差异(P<0.01)结论他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张反应的影响具有浓度依赖性,他达拉非对慢性肾功能衰竭兔阴茎海绵体平滑肌舒张反应的影响优于罂粟碱及硝普钠,他达拉非可能是治疗慢性肾功能衰竭性阴茎勃起功能障碍的理想药物。

Long-term success in lung transplantation continues to be challenged by chronic graft dysfunction,which is manifest as obliterative bronchiolitis.

肺移植的长期成功率受到慢性移植物功能障碍的限制,而慢性移植物功能障碍主要原因是闭塞性细支气管炎。

Objective To assess the changes of local and global left ventricular systolic long axis function in patients with diastolic heart failure by strain rate imaging and compare with isolated left ventricular diastolic dysfunction and left ventricular systolic heart failure to discuss its clinical value.

目的 应用应变率显像技术检测舒张性心力衰竭患者左心室局部及整体心肌长轴收缩功能的变化,并与单纯性左心室舒张功能障碍和收缩性心力衰竭患者进行比较,进一步探讨其临床意义。

Many of researches previous demonstrated that mature mammalian hair cells of Corti organ were lack of capability of regeneration absolutely,but preserved a limit regeneration capacity still in vestibular sensory epithelium.

目前,周围性前庭功能障碍的减轻主要依靠中枢性前庭功能的代偿,而不是前庭感觉上皮本身结构和功能的恢复。

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