性功能

1、Neural network correlated with LIFG and RIFG exists in normal subjects in resting-state,which might be the neural foundation in retaining the normal language function;2、The left fusiform gyrus,bilateral medial frontal gyrus and right anterior cingulum in aphasia patients after stroke showed low degree correlation,that might be one of the mechanisms of aphasia;3、The brain regions showed positive correlation with RIFG in aphasia patients only exist in right hemisphere in resting-state as well as which exist in bilateral hemisphere in normal subjects,suggested that RIFG is out of correlation with the left hemisphere in aphasia patients;4、The left thalamus showed positive correlation with RIFG only in normal subjects, inferred that the left thalamus might be an important mesomerism structure in the correlation of bilateral hemisphere;5、Left insula showed stronger positive correlation with RIFG in normal subjects than that in aphasia patients,suggested that dominant hemisphere insula is important in retaining in normal language function.

1、正常人在静息状态下即存在与LIFG和RIFG具有相关性的神经网络，该网络可能是维持正常语言功能的神经基础；2、脑梗死后运动性失语患者左侧梭状回、双侧额叶内侧回、右侧前扣带与LIFG的连接程度的减低可能是运动性失语的发生机制之一；3、与RIFG正相关的脑区在对照组为双侧半球分布，而在患者组仅出现在右侧半球，说明患者组RIFG与左侧半球的连接中断；4、RIFG与左侧丘脑的正相关性仅出现在正常对照组中，推测左侧丘脑可能是联系两侧半球功能区的重要中介结构；5、对照组与RIFG正相关性明显高于患者组的脑区位于左侧岛叶，说明优势半球岛叶对维持正常语言功能具有重要作用；第二部分脑梗死运动性失语患者语言恢复机制的静息态fMRI初步探讨目的：运用fMRI技术，采用种子点方法在静息状态下分析脑梗死运动性失语患者不同的恢复阶段语言功能连接方式。

In chapter three, molecular imprinting chiral stationary phases against amino acid derivatives utilizing 2-vinylpyridine+acrylamide (2-VP+AM) as combined functional monomers were prepared. Comparing combined functional monomer 2-VP+AM with AM and methacrylic acid+2-VP, the former, 2-VP+AM showed higher imprinting ability. Explanation was given according to the compatibleness between the functional monomer and the imprinted molecule.

第三章系统考察了复合功能单体2-乙烯基吡啶+丙烯酰胺制备氨基酸衍生物分子烙印手性固定相的情况，发现复合功能单体2-乙烯基吡啶+丙烯酰胺烙印体系与丙烯酰胺及复合功能单体2-乙烯基吡啶+甲基丙烯酸烙印体系相比，对氨基酸衍生物表现出更好的烙印能力，验证了功能单体与烙印分子之间存在着匹配性的观点。

ResultsThe similarity, digit span, digit sign, picture, picture remembrance , vision renew in patients after treatment were higher than those before treatment ( P .05). As to the total number, total error number and persistent error number of WCST (P . 05).DiscussionIn this study, thirty - five patients who took Risperdal treatment have cognitive function disorder in different disagree, after 12 weeks, nine items among twelve items reflecting cognitive function have significant difference , indicate cognitive deficits in schizophrenia are reversible and related to new type antipsychotic drug .

实验结果 35例患者在服用利培酮治疗前和治疗12周后认知功能的测验的比较，在相似性、数字广度、数字符号、填图、图片回忆、视觉再生测验中有显著性差异（P＜O.05L在＊qT中，总测验数、总错误数、持续错误数均有显著性差异沙＜o.05人讨论本研究中35例病人应用利培酮治疗前均有程度不同的认知功能损害，经12周治疗后，反映认知功能的十二项分测验中的九项均与治疗前呈显著性差异，提示精神分裂症的认知功能损害具有可逆性，且与新型抗精神病药物密切相关。

［Objective］To explore the technique of arthroscopy plus radiotherapy in the treatment of pigmented villonodular synovitis of the knee and to evaluate its clinical value［Method］A total of 14 cases of pigmented villonodular synovitis of the knee were treated from January 2000 to July 2003Intraarticular excision under arthroscope with a combined application of routine intrusments and Bipolar radiofrequency was performed on all these 14 cases,and postoperative radiotherapy for diffused pigmented villonodular synovitis of the knee,13 patients were followed up for 10~45 months,and were evaluated for range of motion,pain,swelling effusion［Result］Thirteen cases according to the International Knee Documentation Committeecriteria,subjective knee score was (587+64) and (865 ±57) respectively before surgery and at the last followup［Conclusion］In case of pigmented villonodular synovitis of the knee joint,arthroscopical synovectomy can make good surgical results,and postoperative radiotherapy is an effective treatment for diffused pigmented vilionoclular synovitis of the knee

作者：王晓旭，廖瑛，黄华扬，席雅文，李朝旭，韩志关节镜；放射治疗；膝关节；滑膜炎；色素绒毛结节性摘要：［目的］探讨采用关节镜结合放射治疗膝关节色素沉着绒毛结节性滑膜炎的方法及其临床应用价值。［方法］2000年1月～2003年7月，共收治14例膝关节色素沉着绒毛结节性滑膜炎患者，采用关节镜下常规器械加双极射频进行关节内病变切除，术后弥漫性色素沉着绒毛结节性滑膜炎辅以放疗，13例通过10~45个月的随访，了解患膝活动度、疼痛、肿胀情况。［结果］13例随访患者，术前国际膝关节评分委员会膝关节功能主观评分为（587±64）分，最后随访时，IKDC膝关节功能主观评分为（865±57）分。［结论］通过关节镜能完成膝关节色素沉着绒毛结节性滑膜炎滑膜较彻底切除，对弥漫性膝关节色素沉着绒毛结节性滑膜炎辅以术后放疗是一种有效方法。

Results: Tyroserleutide can significantly increase the life span of H22 tumor-bearing mice by 50-70% in dosages of 20ug/kg/d-80ug/kg/d,specially the high dosage of 80ug/ml can significantly increase the life span by 69.24%; Tyroserleutide can inhibit the growth of transplanted hepatocellular tumor BEL-7402 in nude mice,the rate of tumor inhibition was25-50% in dosages of 40-320ug/ml ,the inhibition rate of 160ng/ml was 44.03%; Tyroserleutide could inhibit the growth of H22 and BEL-7402 tumor in a dose-dependent manner. Simultaneously, tumoricidal activity of tyroserleutide against BEL-7402 cell line in vitro was observed hinger when compared with the control group(P.05).The inhibition effect of 72hrs was higher than 24hrs,48hrs,96hrs.And specially the high dosage of 160ug/ml can significantly inhibit growth of tumor cell by 19.36%. Tyroserleutide can activated PEM and marked enhance cytotoxicity andphagocytosis functions in vitro and in vivo. The OD values of cytotoxicity were observed hinger when compared with the control group(P.05).The cytotoxicity of macrophages activated by tyroserleutide against BEL-7402 and B16-F10 was 35.58%,61.2% in vitro and21.39%,47.63% in vivo. The cytotoxicity rate of nude mice PEM was 32.86%,73.07% in vivo. Furthermore, tyroserleutide alone could stimulated the production of IL-1B TNF- a and NO by M . Tyroserleutide and LPS could synergistically activated M producing more cytotoxicity effectors. Conclusion: Tyroserleutide had inhibition functions against hepatoma carcinoma .Its possible mechanisms were related to the affect that Tyroserleutide could inhibit tumor cell directively and induce tumor cells apoptosis or death effectively.

结果：酪丝亮肽能显著延长腹水型肝癌H_(22)小鼠的生存时间，给药剂量为80μg／kg／d时疗效最显著，达到69.24％，在20μg／kg／d-80μg／kg／d剂量范围内生命延长率为50-70％，给药剂量与荷瘤鼠生存时间呈现一定量效关系；酪丝亮肽能显著抑制人肝癌BEL-7402移植瘤裸鼠的肿瘤生长，给药剂量为160μg／kg／d时疗效最显著，抑制率为44.03％，并且在40-320μg／kg／d剂量范围内抑制率为25-50％，给药剂量与肿瘤抑制率呈现一定量效关系；酪丝亮肽体外对人肝癌BEL-7402细胞生长有一定的抑制作用，在作用72hrs时各浓度酪丝亮肽对肿瘤细胞的抑制作用较24hrs、48hrs、96hrs明显，其中浓度为100μg／ml时抑制率达19.36％；酪丝亮肽体内外均能增强小鼠腹腔巨噬细胞对肿瘤细胞的杀伤：体外作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与效应细胞对照组相比有显著性差异(P＜0.05)杀伤率分别达到35.58％、61.2％；体内作用中巨噬细胞对BEL-7402、B16-F10的杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P 。05)，杀伤率分别达到21.39%、47.63%；裸鼠腹腔巨噬细胞经酪丝亮肤作用后对BEL一7402、B 16一F10杀伤功能明显增强，与生理盐水对照组相比有显著性差异(P.05)，最高杀伤率分别达到32.86%、73.07%；酪丝亮肤能增强单核巨噬细胞系统的吞噬功能，吞噬指数与生理盐水组比较有显著性差异(P.05)；酪丝亮肤体外作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与效应细胞对照组相比有显著性差异(P.05)；酪丝亮肤体内作用能促进小鼠腹腔巨噬细胞分泌合成细胞毒效应分子IL一lp、TNF一Q和NO，与生理盐水对照组相比有显著性差异(P.05)；酪丝亮肤能促进鼠巨噬细胞株R戌W264.7分泌合成IL一1p和NO，IL一1日、NO水平分别在酪丝亮肤作用24hrs、12hrs时达到高峰，酪丝亮肤单独应用能提高巨噬细胞的分泌合成功能，而且酪丝亮肤能与LPS协同作用刺激巨噬细胞的细胞毒效应分子分泌合成。

Result:the incidence of AP went up year by year;(2)bile tract disease is the major reason,but hyperlipdemic AP should be attach importance to for its higher and higher incidence;(3)mean age of biliary AP is higher than alcohlolic and hyperlipdemic AP;(4)the difference of sex is significant in biliary AP and alcohlolic AP;(5)the incidence of local omplications is lower than alcohlolic and hyperlipdemic AP,but the difference is of no significance in view of systemic complications;(6)lungis of the most liability for dysfunction,and renal dysfunction is most closely related to death ;(7)ESS is associated with AP and related to the severity and prognosis .

结果表明：(1)急性胰腺炎发病率呈逐年上升趋势；(2)胆道疾病仍是急性胰腺炎的首要病因，高脂血症性胰腺炎明显增多，应受到重视；(3)胆源性胰腺炎患者年龄高于酒精性和高血脂性等其它原因的胰腺炎；(4)性别差异在胆源性、酒精性胰腺炎中显著；(5)胆源性胰腺炎出现局部并发症几率少于酒精性和高血脂性胰腺炎，而在全身并发症上无明显差异；(6)重症急性胰腺炎中，肺脏最易发生功能障碍，肾功能障碍与死亡关系最密切；(7)急性胰腺炎易伴发正常甲状腺病态综合症，并与其严重程度和预后相关。

Had rarely or never used protective;(11) MiceGrayAuto had realized the automatic processing of video data from the sexual preference observation system of rats, and MiceGrayManu had accomplished the analysis of images of sexual behaviors of rats;(12) Peripheral given of high dose androgen to female rats before its brain sexual differentiation had caused masculinization and defemininization in female rats, therefore led to homosexuality, and based on the results, we had established the female rat homosexual model;(13) Peripheral given of estrogen to male rats before its brain sexual differentiation had little effects on the sexual preference and sexual behavior of adult rats;(14) Peripheral given of estrogen antagonist to male rats before its brain sexual differentiation had markedly reduced masculine sexual behavior and interfered male sexual preference, but had no effect on feminine sexual behavior, and based on such results, we had established the male rat homosexual model, however the model have to be improved for better sensitivity;(15) The volume of sexually dimorphism nucleus of the preoptic area of the high dose androgen-treated female rats was significantly greater, while on the other hand the volume of AVPV of which was significantly lesser, than the female rat control.

并且有17.79％的男性同性恋者在1年内与异性保持着性关系。但在与异性阴道性交时，绝大多数（92.51％）偶然或不使用安全套；(11)MiceGrayAuto软件实现了大鼠性偏爱视频数据自动处理功能，MiceGrayManu软件实验了大鼠性行为图象分析功能；(12)大脑性分化前高剂量的雄激素有促雌鼠雄性化和去雌性化的作用，并表现为同性性倾向，建立了雌鼠同性恋模型；(13)在雄鼠大脑性分化前外周给予雌激素对成年后的性偏爱和性行为未产生明显影响；(14)在雄鼠大脑性分化前外周给予雌激素拮抗剂明显削弱雄性性行为，阻碍了雄性性偏爱，但雌性行为无明显变化，雄鼠的同性恋模型还有待进一步调整和改进：(15)高剂量雄激素处理的雌鼠SDN-POA体积明显大于对照雌鼠组，而AVPV体积明显小于对照雌鼠组。

Peer acceptance is the mediator of the relationship between externalizing problem behaviors and loneliness.

结果发现，儿童的外部问题行为在家庭功能与同伴接受性之间起着中介作用，同伴接受性在外部问题行为与孤独感之间起着中介作用；内部问题行为是家庭功能影响儿童孤独感的中介，而外部问题行为与同伴接受性依次组成家庭功能与孤独感联系的另一间接作用路径；不仅如此，家庭功能对儿童孤独感还有较强的直接作用。

All through the simplicity of their forms, colors richness, the diversity patterns, exchange and create the kind of lyrical, sexual summarized its aesthetic characteristics, and aesthetic functions of reflection, inspiration functional, educational functions and self-entertainment functions describes its aesthetic function.

本文通过对其形式的简易性、音色的丰富性、形态的多样性、交流的亲切性以及创造的抒情性等概括它的审美特征，并以审美的反射功能、激励功能、教育功能和自娱功能等描述了它的审美功能。

A better understanding of the function of spleen has been gained recently, owing to the in-depth studies on the structure, cellular function, secretion and innervation of spleen. It is generally accepted that the spleen is the important part of the regulation network between immune, nerve and endocrine system. The spleen has much more function besides blood filtering and storage, haematogenesis, and immunization, and its immune function has characteristics of \\\\\\\"two-way\\\\\\\" and \\\\\\\"phase\\\\\\\".

近年来，随着对脾脏组织结构、细胞功能、分泌功能和神经支配的深入研究，对于脾脏的功能有了更加深入的认识：脾脏是机体免疫-神经-内分泌网络调节中心的一个重要组成部分，其功能并不仅仅局限于滤血、免疫、造血和储血等，而且脾脏的免疫功能具有&双向性&和&时相性&的特点。

Do you know, i need you to come back

你知道吗，我需要你回来

Yang yinshu、Wang xiangsheng、Li decang,The first discovery of haemaphysalis conicinna.

1〕 杨银书，王祥生，李德昌。安徽省首次发现嗜群血蜱。