念珠

Along with the fluconazole solution density rise,the experimental two kind of strain various glucose density is higher,showe d the glucose consumption are less,takes the logarithmof the medicine de nsity,discovered the logarithm the medicine density and each glucose den sity presents the linear relations;Carries on the analysis comparison to under the fluconazole function two kind of strain linear relations,disc overed the relations of the two strains has the nonuniformity.3 Compare the fluconazole induction reaiatance SC5314 strain and sens itive strain compares,its difference gene expression mainly concentrates in:The code proteinase body and the protein hydroltyic enzyme gene,in the code sugar fat metabolism process is connected the protein gene,the cell cycle correlation gene,the duplication and the translation adjustme nt correlation gene,the stress response correlation gene,the line plast ochondria correlation gene,the cell wall function related gene.4 Candida albicans SC5314 induction resiatance strain was processed b y Xianglian solution,its expression change gene mainly is:Code stress re sponse family protein gene,biomembrane relevant gene,a code proteinase body gene race,code cell cycle related protein gene,duplication and tra nslation adjustment related protein gene.5 The clinical reaiatance strain Candida albicans was processed by Xi anglian solution,its expression change gene mainly is:Codes the hot sho ck protein gene,the serine/threonine protein activating enzyme gene,the proteinase body family gene,the regulation copies and translates the ge ne.

随着氟康唑药液的浓度上升，试验的两种菌株各孔葡萄糖浓度越高，说明葡萄糖消耗越少，经过药物浓度取对数后进行分析，发现取对数后的药物浓度和每孔中葡萄糖浓度者呈现线性关系；对氟康唑作用下的两种菌株的线性关系进行分析比较，发现对两种菌株作用具有不一致性。3氟康唑诱导的耐药SC5314菌株与诱导前的敏感株相比，其差异基因表达主要集中在：编码蛋白酶体及蛋白水解酶的基因，编码糖脂代谢过程中相关蛋白的基因，细胞周期相关基因，转录及翻译调节相关基因，应激反应相关基因，线粒体相关基因，细胞壁功能相关基因。4白念珠菌SC5314诱导耐药株经香莲外洗液作用后，其表达变化的基因主要是：编码应激反应家族蛋白的基因，生物膜相关性基因，编码蛋白酶体基因一族，编码细胞周期相关蛋白基因，转录及翻译调节的相关蛋白基因。5白念珠菌临床耐药菌株经香莲外洗液作用后，其表达变化的基因主要是：编码热休克蛋白基因，丝氨酸/苏氨酸蛋白激酶基因，蛋白酶体家族基因，调控转录及翻译基因。

Fluconazole is a reasonable alternative in selected patients in settings where the risk of Candida glabrata and C. krusei are low and who have not been treated with azole antifungals in the past 3 months.

对于光滑念珠菌和克柔念珠菌感染风险较低的医疗机构中的患者以及过去3个月内未接受过唑类抗真菌药物治疗的患者，也可用氟康唑替代。

In the present study, we examined the large-scale gene expression profiles with six sets of matched clinical and experimental fluconazole susceptible and resistant C. albicans strains by microarray analysis. We observed that azole resistances developed in multiple circumstances are all associated with increased expression of CDR mRNA. We also identified some common differential expressed genes and some interesting function-linked gene groups involved in drug-resistance.

利用所构建的基因芯片我们研究了共六对氟康唑敏感和耐药白念珠菌配对菌株的大规模基因表达谱，证实不同环境下产生的白念珠菌耐药性均与多药耐药基因CDR的mRNA表达增加有关，并从中鉴定了一些与药物耐受性相关的共同差异表达基因和一些有趣的功能连锁基因群。

And according the results of the fluconazole sensitivity, differential expression level of CDR1 mRNA was showed on the candida albicans azole resistance and sensitive isolates, we want to discover the molecular mechanism of CDR1 expression regulation by detecting whether there were the mutations on the upper stream of the CDR1 gene.

CDR1基因在白念珠菌唑类耐药/敏感菌株中的表达情况观察，对念珠菌的mRNA进行NORTHERN BLOT检查，发现唑类耐药株与敏感株在CDR1基因表达上存在显著差异。3。

And according the results of the fluconazole sensitivity, differential expression level of CDRl mRNA was showed on the Candida albicans azole resistance and sensitive isolates, we want to discover the molecular mechanism of CDRl expression regulation by detecting whether there were the mutations on the upper stream of the CDRl gene.

CDRI基因在白念珠菌哇类耐药／敏感菌株中的表达情况观察，对念珠菌的mRNA进行NORTHERN BLOT检查，发现哇类耐药株与敏感株在CDRI基因表达上存在显著差异。3。

Methods①The minimum inhibitory concentration and the minimum fungicidal concentration of citral against C.

方法①参照NCCLS M27A方案中的微量液基稀释法测定柠檬醛和氟康唑对原始白念珠菌的最低抑菌浓度和最低杀菌浓度；②采用多步诱导法，观察在含梯度浓度(1～50MIC)柠檬醛培养基上连续转种的白念珠菌MIC的变化情况，以氟康唑作为阳性对照，同时设空白对照和溶媒对照；③将敏感性下降的诱导株在无药培养基上连续转种10次后，检测其MIC值；④测定柠檬醛对氟康唑敏感性下降诱导株的MIC值。

VEC of conglutinate of bacterium of beads of conclusion SIgA dialogue has inhibition, of SIgA level reducing is one of reasons that CV comes on, with Bai Nianzhu bacterium source has nothing to do.

结论sIgA对白念珠菌粘附VEC有抑制功能，sIgA水平的降低是CV发病的原因之一，和白念珠菌来源无关。

The method uses radiative immunity law to determine CV group, healthy group and content of the SIgA in taking secretion of bacterium group vagina, method of the conglutinate outside using system determines white beads bacterium is epithelial to the vagina (the conglutinate ability of VEC), the influence of VEC of conglutinate of white beads bacterium when observing SIgA standard.

方法采用放射免疫法测定CV组、健康组及带菌组阴道分泌物中sIgA含量，用体外粘附方法测定白念珠菌对阴道上皮细胞的粘附能力，观察sIgA水平时白念珠菌粘附VEC的影响。

Objective: To understand the situation of genotype and the result of drug susceptibility of Candida albicans isolated.

目的：了解白色念珠菌的基因分型情况以及不同基因型白色念珠菌的药敏试验结果。

Candida colonisation did not enhance oalbumin permeation in mast cell deficient W/W mice but did in congenic littermate control +/+ mice. Reconstitution of mast cells in W/W mice by transplantation of bone marrow deried mast cells restored the ability to increase oalbumin permeation in response to Candida colonisation.

念珠菌定植不加强肥大细胞缺陷W/W小鼠的蛋白通透性，而其同系同窝对照+/+小鼠则有加强，W/W小鼠通过骨髓肥大细胞移植重建肥大细胞功能可恢复念珠菌定植后对卵白蛋白通透性的增强作用。

On the other hand, the more important thing is because the urban housing is a kind of heterogeneity products.

另一方面，更重要的是由于城市住房是一种异质性产品。

Climate histogram is the fall that collects place measure calm value, cent serves as cross axle for a few equal interval, the area that the frequency that the value appears according to place is accumulated and becomes will be determined inside each interval, discharge the graph that rise with post, also be called histogram.

气候直方图是将所收集的降水量测定值，分为几个相等的区间作为横轴，并将各区间内所测定值依所出现的次数累积而成的面积，用柱子排起来的图形，也叫做柱状图。