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Polarity,or action and reaction,we meet in every parto nature;in darkness and light;in heat and cold;in the ebband low o waters;in male and emale;in the inspirationand expkation o plants and animals;in the equation oquantity and quality in the luids o the anima1body;in thesystole and diastole20 the heart;in the undulations o luids-arjld--o sound:in the centriuga1and centripeta1gravity3;inelectricity,galvanism,and chemica1ainity.

两极性或作用与反作用在自然界中随处可见:黑暗与光明、炎热与寒冷、潮落与潮涨、雄性与性、动植物的吸气与呼气、动物体内的体液数量与质量的均衡、心脏的收缩与舒张、液体的波动和声音的起伏、离心力与向心力;此外在电荷、电流和化学的亲和性上也不难发现这点。

Combined with animal model of peradaptation to myocardium ischemia , the research observed the level of enzymatic dynamics of myocardium, SOD,MDA,ET and correlation peptide of calcitonin gene in peripheral blood and cardiac function, apoptic cell and expression of apoptosis regulatory gene, ultrastructure of myocardium with BIOPAC16, in situ end labeling and hybridism, optic microscope and electron microscope. The study of animal model of peradaptation to myocardium ischemia illustrated that the peradaptation and pretreatment with Wenxin capsule could be positively protective for the injury of ischemia reperfusion. The protection is mainly reflected by reduction of infarction area, correction of heart rhythm abnormality of ischemia reperfusion, melioration of the contraction and relaxation function of myocardium, recovery of the subcellular structure and themelioration of the abnormality of biochemical and bioactive substance in the myocardium.

并结合心肌缺血预适应动物模型,采用BIOPAC16导生理记录和分析处理系统处理心肌功能指标,采用原位末端标记及原位杂交技术标记凋亡细胞及凋亡相关调控基因的表达,采用光电镜技术观察心肌超微结构的变化,同时观察外周血心肌酶、超氧化物歧化酶、丙二醛、内皮素、降钙素基因相关肽等水平,结果表明心肌缺血预适应及温心胶囊预处理对心肌缺血再灌注损伤具有肯定的保护作用,其保护心脏作用主要表现在缩小心肌梗死范围、抗缺血再灌注心律失常、改善心肌收缩和舒张功能、减轻心肌超微结构损伤,调节心肌生化物质及生物活性物质的生成和释放。

These relative risks did not change significantly after adjustment for age; sex; total cholesterol, low-density lipoprotein cholesterol, or triglyceride levels; carotid-wall thickness; smoking status; the presence or absence of diabetes and systolic and diastolic hypertension; body mass index; and other risk factors. In women, Lp lipoprotein levels were not related to cardiovascular risk, even after adjustment for estrogen use or nonuse.

这些相对危险性经过年龄、性别、总胆固醇、低密度脂蛋白胆固醇、或三酸甘油酯浓度、颈动脉管壁厚度、吸烟状态、糖尿病和心脏收缩及舒张高血压的有无、身体质量指数、和其他的危险因子的调整后并没有显著改变,而在女性方面,Lp脂蛋白浓度与心血管风险无关,即使经过雌激素有无使用的调整后也是如此。

Methods:to analyze electrocardiogram,echocardiogram,left ventriculography,nuclear magnetic resonance results of 13 cases with ahcm.results:12 cases had apical wall thickening in echocardiogram, 3 cases had a "spade-like" configuration on left ventriculogram, 7cases were misdiagnosed as coronary heart disease initially.conclusion:ahcm is easy to be misdiagnosed as coronary heart disease, echocardiogram plays important role in the diagnosis of ahcm, in patients with suspicion of ahcm and inadequate echo images, the use of contrast echocardiography or mri should be considered.

对13例ahcm的心电图、超声心动图、左室造影及磁共振结果进行分析。结果:13例ahcm中心电图有特征性改变12例,超声心动图提示心尖区增厚12例,左室造影提示舒张期呈"黑桃"形改变3例,初诊误诊为冠心病7例。结论:ahcm易被误诊为冠心病,超声心动图是诊断该病的重要手段,必要时可做心脏超声造影术或磁共振检查。

Cardiac hypertrophy and extracellular matrix remodeling happened as a result of chronic overrange of pressure in heart and hypervolaemia which lead to damage of relaxation and compliance of heart.Drugs including renin-angiotensin converting enzyme inhibitor,angiotensin receptor blocker,aderergic receptor blocker,aldrosteron antagonism,tatins endothelin receptor blocker pancreatic kiniogenase and calcalium channel blocker,can delay or reverse the remodeling by several mechanisms.

主要表现为心脏在慢性超负荷的压力、容量作用下发生的病理改变致使左室肥厚组织胶原结构发生改变,导致心肌顺应性降低,舒张功能受到损害;作用于肾素-血管紧张素系统的药物及肾上腺素受体阻滞剂、醛固酮拮抗剂、他汀类药物、内皮素受体拮抗剂、胰激肽原酶、钙通道阻滞剂等药物通过不同途径和机制延缓和逆转左心室重构。

Lactated Ringer's or 7.5% NaCl+6% dextran 70 was given for resuscitation 6h postburn.The volumes and rates of fluid infusion were controlled basically on the urinary output of 1.0ml*kg-1*h-1 and cardiac output of 70%~80% of preburn values.The volume load,+dp/dtmax,-dp/dtmax,CI,DO2 and VO2 were obtained to evaluate the effect of HSD resuscitation. Results The resuscitated volume of HSD was 30.56% less during first 24h postburn and 59.50% less at 4h after resuscitation than LR's.

采用犬35%TBSA Ⅲ度烧伤模型,伤后6 h分别用乳酸林格液及HSD进行复苏,并以每h尿量为1.0ml/kg及心输出量为伤前值的70%~80%来调整输液速度及输液量,观察HSD在复苏中容量负荷、左心室等容收缩期最大压力变化速率及左心室舒张期压力下降最大变化速率、心脏指数、氧供给(DO2)及氧消耗(VO2)等的变化。

The volumes and rates of fluid infusion were controlled basically on the urinary output of 1.0ml*kg-1*h-1 and cardiac output of 70%~80% of preburn values.The volume load,+dp/dtmax,-dp/dtmax,CI,DO2 and VO2 were obtained to evaluate the effect of HSD resuscitation. Results The resuscitated volume of HSD was 30.56% less during first 24h postburn and 59.50% less at 4h after resuscitation than LR's.

采用犬35%TBSA Ⅲ度烧伤模型,伤后6 h分别用乳酸林格液及HSD进行复苏,并以每h尿量为1.0ml/kg及心输出量为伤前值的70%~80%来调整输液速度及输液量,观察HSD在复苏中容量负荷、左心室等容收缩期最大压力变化速率及左心室舒张期压力下降最大变化速率、心脏指数、氧供给(DO2)及氧消耗(VO2)等的变化。

Finally statistical analysis is conducted.Result: Orally taking Xuefu Zhuyu Tang and calming-wind medicines can ease stenocardia,improve ECG,enhance the stopped rate of nitroglycerin,better the heart contraction and dilation,regulate blood fat,promote blood rheology,lower CRP、ET、TXB2,raise NO、6-keto-PGF1αand so on,compired with the control group,it is obviously statically meaningful without obvius adverse reaction.

结果:血府逐瘀汤加治风活络药物内服治疗能有效地缓解心绞痛和临床症状;改善心电图;提高速效扩冠药的停减率;改善心脏的收缩及舒张功能;调节血脂;改善血液流变学;降低CRP、ET、TXB2的水平,升高NO、6-keto-PGF1α的水平等,与对照组相比,有显著的统计学意义,且未发现明显的不良反应。

Methods:to analyze electrocardiogram,echocardiogram,left ventriculography,nuclear magnetic resonance results of 13 cases with ahcm.results:12 cases had apical wall thickening in echocardiogram, 3 cases had a "spade-like" configuration on left ventriculogram, 7cases were misdiagnosed as coronary heart disease initially.conclusion:ahcm is easy to be misdiagnosed as coronary heart disease, echocardiogram plays important role in the diagnosis of ahcm, in patients with suspicion of ahcm and inadequate echo images, the use of contrast echocardiography or mri should be considered.

对13例ahcm的心电图、超声心动图、左室造影及磁共振结果进行分析。结果:13例ahcm中心电图有特征性改变12例,超声心动图提示心尖区增厚12例,左室造影提示舒张期呈&黑桃&形改变3例,初诊误诊为冠心病7例。结论:ahcm易被误诊为冠心病,超声心动图是诊断该病的重要手段,必要时可做心脏超声造影术或磁共振检查。

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