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MAIN OUTCOME MEASURES:The changes of INa,ICa-L,Ito and IK1 in the cardiomyocytes taken from the infarcted area of epicardium 24 hours after AMI in both the AMI and control groups.

主要观察指标: AMI后 24 h AMI组和对照组心外膜梗死区心肌细胞 INa, ICa-L, Ito和 IK1的变化。

Methods Thirty domestic dogs were randomly divided into 5 groups (6 in each group ): model control group, positive control group, and TGP groups with doses of 2.0, 4.0, and 8.0 mg·kg-1, respectively. The descending branch of left coronary artery was ligated to construct the model of myocardial infarction in the anesthetic thoraco-opened dogs. The effect of TGP on epicardium electrocardiogram , myocardial infarction size and serum myocardial enzymes were observed.

取杂种犬30只,随机分为5组(每组6只),分别为模型对照组、阳性对照药物组及TGP 2.0、4.0和 8.0 mg·kg-1剂量组;采用结扎麻醉开胸犬左冠状动脉前降支制备急性心肌梗塞模型,观察TGP对心外膜电图、心肌梗塞面积和血清心肌酶的影响。

In terms of safety there is no doubt a real equivalency of death, MI, stroke in the two groups.

从安全性的角度看,PCI组和CABG组死亡、心肌梗死和脑卒中事件上没有差异。

Objective: To study the effects of estradiol on atrial specific granules of myocardial cells in ovariotomy rats.

目的:研究雌二醇对卵巢切除大鼠心肌细胞心房特殊颗粒的影响。

But in the periods after taking evacuant, the heart rate and the myocardial oxygen consumption of kaiselu group were higher obviously than that of castor oil group (P=0.029, P=0.019). No obvious difference in other parameters was observed between two groups.

开塞露肛注者与蓖麻油口服者在排便过程中各时段心脏自律性和心肌缺血情况的变化基本相同。

ResultsMacroscopic examination showed no excrescence,thrombus formation,arm fractures and corrosion.The devices were covered with collagen fibrosis and discrete endocardial cells,apparent inflammatory infiltration in the devices and around the devices 1 month after implantation.The implants were nearly endothelialized,while the inflammatory reaction relieved gradually,with myocardial cells ingrowth at the edges of the device 3 months after implantation.The devices were completely covered with endocardium and fibrous tissue.Moreover,endothelial cells could be found on the smooth microscrew adaptor.The inflammatory reaction diminished with a few chronic inflammatory cells existing.Neovascularization and lymphatic vessels ingrowth could be observed 6 months after implantation.

结果所有封堵装置表面均没有发现赘生物、血栓形成、支架发生断裂及被腐蚀;术后1个月,封堵装置表面被胶原纤维和散在内皮细胞所覆盖,大量炎症细胞浸润,封堵装置边缘有小灶性炎症细胞浸润;术后3个月,封堵装置表面几乎被内皮细胞所覆盖,炎症细胞较1个月时明显减少,封堵装置内见纤维化,封堵装置边缘心肌细胞浸入;术后6个月,封堵装置表面完全被心内膜和纤维组织所覆盖,伞尖表面光滑并有内皮细胞上爬,炎症反应明显消散,但仍有少量慢性炎症细胞存在,装置内有新生的血管、淋巴管长入。

Objective To explore the variation of the exon 11 of MEF2A gene in patients with acute myocardial infarction.

目的 研究MEF2A基因第11外显子在普通急性心肌梗死患者中的变异情况。

Histological analysis was performed on myocardial samples taken at LVAD implantation and explantation.

对LVAD植入或移出时获得的心肌标本进行组织学分析。67例心衰病人入选本研究。

Eleven of the 15 patients had sufficient myocardial recovery to undergo explantation of the left ventricular assist device a mean of 320±186 days after implantation of the device. One patient died of intractable arrhythmias 24 hours after explantation; another died of carcinoma of the lung 27 months after explantation.

结果:植入左室辅助装置后经过平均320±186天的随访,15例病人中有11例心肌功能得到有效恢复。1例在植入后24小时死于难治性心律失常,另外1例在植入27个月后死于肺癌。

OBJECTIVE To study the effects of Herba Epimedii extractive on myocardial ischemia in rats.

目的 研究淫羊藿提取物对大鼠急性心肌缺血的影响。

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