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心肌梗死

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Methods The electrocardiography, myocardial enzyme and magnetic resonance imaging data of 44 AMI patients were analyzed retrospectively.

但是 ,在冠状动脉开放的梗死区心肌经常合并有微血管阻塞,从而影响梗死心肌的修复和重塑。

HISI treatment prolong the survival time of mice in toxic condition induced by sodium nitrite and duration of electrocardiograph in trachea closed mice .HISI could obviously improve the ischemic electrocardiogram T-wave induced by Pituitrin.ST segment drifts on electrocardiogram in acute myocardial ischemia rats induced by Isoprotereno were obviously opposed by administration of HISI. The myocardial infarction areas, releasement of lactic dehydrogenase 、 creatine phosphokinase significantly increased in myocardial ischemia dogs, HISI treatment prevented these effects .

实验结果表明:苦碟子氯化钠注射液能显著延长小鼠常压缺氧环境及亚硝酸中毒情况下的存活时间,延长小鼠气管夹闭后心电消失时间;可显著改善垂体后叶素诱发的大鼠急性心肌缺血心电图T波异常;明显对抗异丙肾上腺素诱导的急性心肌缺血大鼠心电图ST段的偏移;显著改善冠脉结扎所致急性心肌缺血犬的心外膜心电图缩小其梗死心肌面积,降低心肌耗氧量,减少心肌坏死导致的心肌酶如乳酸脱氢酶、肌酸磷酸激酶的漏出。

Objective To study the effect of implantation of bone marrow mescnchymal stem cells on infarcted myocardium.

目的 探讨自体骨髓间质干细胞移植对梗死心肌基本结构及心肌收缩力的影响。

BACKGROUND: It is a debate of bone marrow mononuclear cells to promote the regeneration of infarcted myocardium.

摘要背景:关于骨髓单个核细胞促使梗死心肌再生存在很大争议,早期研究均认为非常有效,甚至可以分化为心肌细胞,但最近的文献却基本否认了这种说法,认为单个核细胞仅可以有限的促进血管生成。

local intramyocardial administration of 17β-estradiol loaded nanoparticles can effectively promote angiogenesis and decrease infarct size after MI in rats,and do not increase mortality.

心肌内局部注射17β-雌二醇纳米粒可有效促进大鼠梗死后心肌毛细血管生成,减少心梗面积,不增加死亡率,对心梗有较好的修复作用。

Objective To investigate whether uninduced autologous bone-marrow mononuclear cell could survive and differentiate into myocardial cells and endothelial cells in the infarcted heart.

文章摘要:目的探讨未经诱导的自体骨髓单核细胞可否在梗死心肌环境中存活并分化为心肌细胞及血管内皮细胞。

The transplanted cells can be integrated into the vascular walls of the capillaries and arterioles and differentiate into cardiomyocytes.

移植的单个核细胞可以在梗死区域中存活,增殖,分化和迁移,增加梗死区域的微血管数量,再生、再造心肌。

Results According to the score criteria of IBS curve patterns,when IBS curve score were 1 or 2,the magnitude of VIB nd CVIB% were between controlled groups and infracted groups,and comparison to the two there were significant difference,it is ischemic myocardium or viable myocardium.

评为1分及2分的心肌节段即IBS曲线形态评分≤2分者,其IBS周期变异幅度、IBS周期变异率%界于对照组和梗死组之间,且与该二者比较差异有显著性,考虑其为缺血心肌即存活心肌,占43.6%(17/39),但其IBS%与梗死组之间比较无统计学差异。

Results According to the score criteria of IBS curve patterns,when IBS curve score were 1 or 2,the magnitude of VIB nd CVIB% were between controlled groups and infracted groups,and comparison to the two there were significant difference,it is ischemic myocardium or viable myocardium.The segments of IBS curve score≤2 were 43.6%(17/39),there weren's statistical difference between its IBS% and onesof infracted group.

评为1分及2分的心肌节段即IBS曲线形态评分≤2分者,其IBS周期变异幅度、IBS周期变异率%界于对照组和梗死组之间,且与该二者比较差异有显著性,考虑其为缺血心肌即存活心肌,占43.6%(17/39),但其IBS%与梗死组之间比较无统计学差异。

OBJECTIVE: To explore the influence of autologous bone marrow mononuclear cells on vascular endothelial function in patients with myocardial infarction and left heart insufficiency following coronary artery transplantation.

目的:探讨自体骨髓单个核细胞经冠状动脉移植后对心肌梗死并左心功能不全患者血管内皮功能的影响。

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