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心肌梗死

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Combined with animal model of peradaptation to myocardium ischemia , the research observed the level of enzymatic dynamics of myocardium, SOD,MDA,ET and correlation peptide of calcitonin gene in peripheral blood and cardiac function, apoptic cell and expression of apoptosis regulatory gene, ultrastructure of myocardium with BIOPAC16, in situ end labeling and hybridism, optic microscope and electron microscope. The study of animal model of peradaptation to myocardium ischemia illustrated that the peradaptation and pretreatment with Wenxin capsule could be positively protective for the injury of ischemia reperfusion. The protection is mainly reflected by reduction of infarction area, correction of heart rhythm abnormality of ischemia reperfusion, melioration of the contraction and relaxation function of myocardium, recovery of the subcellular structure and themelioration of the abnormality of biochemical and bioactive substance in the myocardium.

并结合心肌缺血预适应动物模型,采用BIOPAC16导生理记录和分析处理系统处理心肌功能指标,采用原位末端标记及原位杂交技术标记凋亡细胞及凋亡相关调控基因的表达,采用光电镜技术观察心肌超微结构的变化,同时观察外周血心肌酶、超氧化物歧化酶、丙二醛、内皮素、降钙素基因相关肽等水平,结果表明心肌缺血预适应及温心胶囊预处理对心肌缺血再灌注损伤具有肯定的保护作用,其保护心脏作用主要表现在缩小心肌梗死范围、抗缺血再灌注心律失常、改善心肌收缩和舒张功能、减轻心肌超微结构损伤,调节心肌生化物质及生物活性物质的生成和释放。

Acute myocardial infarction can increase mRNA and protein expression of HCN2 and HCN4 in infracted region surrounding.

提示急性心肌梗死后梗死边缘区HCN2,HCN4基因在mRNA和蛋白水平的表达升高,骨髓间充质干细胞移植可能通过下调梗死边缘区HCN2,HCN4的表达来降低心律失常。

Methods: the hegcs from the gonadal ridges and dorsal mesenteries of human embryos aged 5-10 weeks were cultured with or without cytokine in culture medium to observe their growth and the effects of different cell culture systems were compared. the hegcs' from passage 4 were transplanted directly to infarcted myocardium.

取5~10周人胚胎生殖腺嵴和背侧肠系膜,用添加和不添加细胞因子的两种培养体系对比进行组织块原代及传代培养,选取生长情况良好的传至第4代的人eg细胞,移植到急性心肌梗死大鼠的梗死心肌周围,分别于移植后1天、1、2、4周处死大鼠,以鼠抗人细胞核抗体mab1281作为示踪剂[1],通过免疫组化方法检测移植细胞的分布。

It were detected that the differences of degree of ST elevation,peak value of cardiac enzymes,the score of ECG,left ventricular ejection fraction,right bundle branch block,shock and heart failure.

目的 通过对急性心肌梗死患者一些临床指标的观察,评价缺血预适应对急性心肌梗死患者预后的。

The positive rate and geometric mean titres of specific lgg antibodies in patients with ami and omi were significantly higher than those in controls.

急性心肌梗死和陈旧性心肌梗死患者血清肺炎衣原体慢性感染率及其抗体滴度几何均数均明显高于对照组。

In this particular study, there are no data on whether patients who got PCI did so because they were too sick to undergo CABG, and there are no data on "completeness" of revascularization in stented patients. Moreover, an important subgroup, patients with left main disease, were not included in the study.

Kaul等指出两组绝对危险的差异很小,三支病变中死亡差异是1.3%,死亡和心肌梗死联合是2.4%,双支病变中死亡差异是1.4%,死亡和心肌梗死联合是2.0%,也就是说更长期随访可能得出CABG更明显的获益,因为CABG益处需要长期才能体现,而DES可能会有晚期血栓的问题。

Methods: A total of 218 patients with ST segment elevated myocardial infarction whose blood routines were obtained at the admission were studied. All cases were divided into two groups according to the neuropil to lymphocyte ratio of small to large size. Then we analyzed the morbidity of AMI complications between the two groups.

入选急性ST段抬高心肌梗死患者218例,入院后即刻抽取静脉血查血常规,按中性粒细胞/淋巴细胞比率的大小由小到大将其分为A、B两组,对两组急性心肌梗死并发症发生率进行比较。

RESULTS: Both HPC and treatment with ruthenium red (5μmol/L) during the first 10 min reoxygenation improved recovery of LVDP±dp/dt and decreased LVEDP, which was associated with reduced infarct size and lactate dyhydrogenase release.

用TTC染色法测心肌梗死面积。结果:低氧预处理和低氧后复氧期的前10min用钌红(5μmol/L)处理均可促进LVDP、±dp/dt,和LVEDP的恢复,减小心肌梗死面积,减少LDH释放。

RESULTS: Both HPC and treatment with ruthenium red (5 μmol/L) during the first 10 min reoxygenation improved recovery of LVDP,±dp/dtmax and decreased LVEDP, which was associated with reduced infarct size and lactate dyhydrogenase release.

用TTC染色法测心肌梗死面积。结果:低氧预处理和低氧后复氧期的前10 min用钌红(5 μmol/L)处理均可促进LVDP、±dp/dtmax和LVEDP的恢复,减小心肌梗死面积,减少LDH释放。复氧期的前10 min用精胺(20 μmol/L)处理可减弱低氧预处理的心脏作用。

Methods 68 patients with AMI were treated by intravenous thrombolytic therapy of streptokinase under electrocardiogram monitoring.

方法在心电图监测下,对68例急性心肌梗死患者行链激酶目的探讨链激酶静脉溶栓治疗急性心肌梗死的疗效。

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