心肌内的

It is concluded that acrolein induces adult mice cardiomyocytes apoptosis, and it may be due to the increased intracellular oxygen free radicals and calcium concentration.

丙烯醛可引起成年小鼠心肌细胞的凋亡，其作用可能是由于细胞内氧自由及钙浓度的增加。

Results showed that L-THP possessed negative inotropic and negative chronotropic action, lowed left ventricular pressure and it's infinitesimal calculus, decreased heart output in per min., shorten 〓 and 〓 of action potential of ventricular papillary muscle of guinea pig and even the plate-phase of action potential disappeared in larger dose group , but prolonged 〓. we studied transmembrane transportation of 〓 after administering L-THP , L-THP not only depressed uptake and increased release of Ca 2+ in normal myocardium, but also it showed stronger inhibition in cell injured by ISO, and fully eliminated the effect of ISO increasing uptake and decreasing release of 〓. By detecting the 〓 content of ventricular single myocyte using fluorescent probe Fluo-3/AM, results correspond to that done above, L-THP decreased 〓 content inside of cell significantly. Using whole-cell mode, we observed the effect of L-THP on Ica in ventricular single cell, it was found that L-THP decreased Ica, the effect increased with increasing it's dose, and had voltage, frequency-dependency. Dose highly corelated to effect, corelative constant is 0.87. When washing cell with normal tyre's solution, Ica could recover, which proved the blocked action of L-THP on calcium channel once again. Meanwhile, L-THP reduced production of MDA in heart injured by ISO in dose-dependent manner, improved content of GSH-Px, in case tissue or cell free from free radical damage.

结果显示，该药物具有负性肌力和负性频率作用，降低左室压及其微分，终使每分心输出量减少；缩短豚鼠心室乳头肌动作电位时程的〓和APD〓，大剂量使动作电位平台消失，〓延长；同位素示踪法研究证实L-THP抑制〓摄取，促进〓释放，降低细胞内的〓含量；单通道水平的研究证实，L-THP减少豚鼠心室肌单细胞内向钙电流，且具有剂量，电压，频率依赖性，其作用易于洗脱，药物剂量与Ica也具有高度相关性（相关系数r为-0.87）；L-THP还可抑制ISO损伤心肌组织所致的丙二醛含量增加，增加谷胱甘肽过氧化物酶的量，使组织细胞免受损伤。L-THP阻断L-型〓通道，抑制〓的摄取，促进〓的释放，降低细胞内〓含量L-THP作用的离子基础。

Cholic acids caused an increase in the concentration of Cytosolic free calcium in a dose-dependent manner.

胆酸对心肌细胞存活率的抑制作用有很强的时间-浓度依赖性，这种抑制作用除了对心肌细胞的直接损伤外，还可能与其造成细胞内&钙超载&有关。

Objective: To study the myocardial protective effects of tetramethylpyrazine on patients undergoing open heart surgery with extracorporeal circulation.

目的：探讨川芎嗪对40例瓣膜置换患者行体外循环心内直视手术心肌保护的效果。

Background— The hallmarks of diabetic cardiomyopathy are cardiac oxidative stress, intramyocardial inflammation, cardiac fibrosis, and cardiac apoptosis.

背景——糖尿病性心肌病的标志是心脏氧化应激、心肌内炎症、心脏纤维化、心脏凋亡。

Results After 3 days for operation, HE staining showed multi-focal myocardial necrosis with inflammatory cells infiltration and necrosis with more involvement in subendocardial region.

结果 术后3天，微栓塞组心肌内点状分布的坏死灶形成，多位于心内膜下，周围炎症细胞浸润明显增多，符合微栓塞病理学改变。

After administration of L-N〓-nitro-Arginine, a specific antagonist of NOS, it was found that the basal and stimulated NO release of blood vessels (aorta, internal carotid, renal and mensenteric artery) was decreased further. The increase of coronary blood flow stimulated by Ach was also reduced further, while the platelet aggregation degree and erythrocyte aggregation index increased significantly. Pathological examination indicated that aortic endothelium was destroyed, the blood vessels in cerebral, cardiac and renal tissues were hypertrophied further and some were almost occluded. The above fin dings resulted in SHR feeded with L-NNA having high incidence of stroke rate and high degree of renal cirrhosis when compared to control SHR. The infarct and hemorrhagic focuci in cerebral tissues, infarct focuci in cardiac tissues, atrophy and hyalinedegeneration of renal glomeruli and degeneration even necrosis of renal tubuli in renal tissues were al so found. The increase ratio of brain and heart to body weight and decrease ratio of kidney to body wei ght further demonstrated that the cerebral, cardiac and renal injuries were aggravated.

在上述结果的基础上进一步给予SHR NOS特异性拮抗剂左旋亚硝基精氨酸后，血管(胸主、颈内、肾及肠系膜动脉)NO基础释放及激动剂刺激释放进一步减少，Ach刺激冠脉流量的增加和胸主动脉内膜NOS活性也进一步减少，血小板聚集程度及红细胞聚集指数显著上升，病理切片显示胸主动脉内皮细胞破坏明显，脑心肾组织内的血管进一步增厚甚至几乎阻塞，导致饲L-NNA的SHR缺血性及出血性脑卒中发生率显著高于对照SHR，脑体重比显著升高；心肌内出现明显的缺血梗塞疤痕灶，心体重比显著升高；肾小球明显萎缩、玻璃样变性，肾小管也变性甚至坏死，使肾硬化程度显著增加呈颗粒性固缩肾，肾体重比也显著减少。

The expressions of VEGF、bFGF、IL-1βin myocardium were measured by RT-PCR and ELISA. Other steps and methods were same with the second part. Results: 1. The cells in 2Gy, 4Gy groups and unirradiated group grew well. All cells in 8Gy and 12Gy groups were dead after irradiation.

30只大鼠随机分为注射上清液组和培养基组，除了采用RT-PCR和ELISE两种方法检测VEGF、bFGF、IL-1β在心肌组织内的表达外，其他实验步骤、方法及检测指标同实验第二部分。

This study suggests that cardiac troponin T is one of the targel-specific antigen applying for myocardia' infarct imaging.

本研究结果表明肌钙蛋白T是心肌内可用于心肌梗塞区显像的靶抗原之一。

In order to explore further mechanism, the present study was designed to investigate the relationship between the protective effects of F2 on myocardial I/R injury and expression of Egr-1, which could be a master switch in I/R injury.?

为进一步完善F2保护心肌缺血再灌注损伤作用的分子机制，以缺血再灌注损伤过程中起重要作用的Egr-1为研究对象，明确F2的作用机制是否与通过影响Egr-1在心肌组织内的表达有关？

Breath, muscle contraction of the buttocks; arch body, as far as possible to hold his head, right leg straight towards the ceiling (peg-leg knee in order to avoid muscle tension).

呼气，收缩臀部肌肉；拱起身体，尽量抬起头来，右腿伸直朝向天花板（膝微屈，以避免肌肉紧张）。

The cost of moving grain food products was unchanged from May, but year over year are up 8%.

粮食产品的运输费用与5月份相比没有变化，但却比去年同期高8％。