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Objective Aim to study the protective effect and mechanism of ligustrate injection on acute myocardial infarct in rats.

目的 探讨川芎嗪对急性心肌梗死模型大鼠的保护作用及机制。

To investigate the factors that influence creating rat model of infarct heart successfully.

目的 探讨成功制备大鼠心肌梗死模型的影响因素。

Myocardial infarction has become one of the leading causes of death in the world.

心肌梗死已经成为全球首要导致死亡的原因之一。

Objective To evaluate the value of echocardiography in the diagnosis of acute myocardial infarction and its complications.

目的 评价超声心动图在急性心肌梗死及其并发症诊断中的应用价值。

Objective To explore the treatment effect of rehabilitation procedures in patients with acute myocardial infarction .

目的 探讨分析康复程序在急性心肌梗死患者治疗中的应用效果。

Objective To study the effect of rehabilitation treatment on the heart function of patients with acute myocardial infarction.

目的 探讨康复治疗对急性心肌梗死患者心功能的影响。

Objective To investigate the effect of nursing intervention on the treatment of patients with acute myocardial infarction.

目的 研究积极的护理干预对于急性心肌梗死患者治疗效果的影响。

Objective: To investigate the homocysteine level in patients of myocardial infarction.

摘 要 目的:探讨同型半胱氨酸与心肌梗死之间的关系。

Objective: To evaluate the impact of age and sex on in-hospital outcomes of patients with acute myocardial infarction.

目的:探讨年龄和性别对急性心肌梗死住院患者预后的影响。

Results showed that L-THP possessed negative inotropic and negative chronotropic action, lowed left ventricular pressure and it's infinitesimal calculus, decreased heart output in per min., shorten 〓 and 〓 of action potential of ventricular papillary muscle of guinea pig and even the plate-phase of action potential disappeared in larger dose group , but prolonged 〓. we studied transmembrane transportation of 〓 after administering L-THP , L-THP not only depressed uptake and increased release of Ca 2+ in normal myocardium, but also it showed stronger inhibition in cell injured by ISO, and fully eliminated the effect of ISO increasing uptake and decreasing release of 〓. By detecting the 〓 content of ventricular single myocyte using fluorescent probe Fluo-3/AM, results correspond to that done above, L-THP decreased 〓 content inside of cell significantly. Using whole-cell mode, we observed the effect of L-THP on Ica in ventricular single cell, it was found that L-THP decreased Ica, the effect increased with increasing it's dose, and had voltage, frequency-dependency. Dose highly corelated to effect, corelative constant is 0.87. When washing cell with normal tyre's solution, Ica could recover, which proved the blocked action of L-THP on calcium channel once again. Meanwhile, L-THP reduced production of MDA in heart injured by ISO in dose-dependent manner, improved content of GSH-Px, in case tissue or cell free from free radical damage.

结果显示,该药物具有负性肌力和负性频率作用,降低左室压及其微分,终使每分心输出量减少;缩短豚鼠心室乳头肌动作电位时程的〓和APD〓,大剂量使动作电位平台消失,〓延长;同位素示踪法研究证实L-THP抑制〓摄取,促进〓释放,降低细胞内的〓含量;单通道水平的研究证实,L-THP减少豚鼠心室肌单细胞内向钙电流,且具有剂量,电压,频率依赖性,其作用易于洗脱,药物剂量与Ica也具有高度相关性(相关系数r为-0.87);L-THP还可抑制ISO损伤心肌组织所致的丙二醛含量增加,增加谷胱甘肽过氧化物酶的量,使组织细胞免受损伤。L-THP阻断L-型〓通道,抑制〓的摄取,促进〓的释放,降低细胞内〓含量L-THP作用的离子基础。

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