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A coronary microthromhoembolism model was successfully established by injecting sodium laurate into the coronary arteries. Coronary micro-thrombogenesis may promote the apoptosis of cardiomyocytes, and is one of the reason for heart function decrease. Telmisartan can efficiently suppress ventricles reconstruction, improve heart function, and inhibit the apoptosis of myocardial cells after microthrombogenesis in coronary artery.

冠状动脉内注射月桂酸钠能够成功建立冠状动脉微血栓的模型;冠脉内微血栓增加心肌细胞的凋亡,是导致心功能下降的原因之一;替米沙坦能有效地抑制心脏重塑,改善心功能,并能抑制冠脉微血栓后心肌细胞的凋亡。

The experimental rats were randomly divided into normal group, ISO group, positive control group and leonurus composition groups.

采用大剂量异丙肾上腺素皮下注射,造成大鼠急性心肌缺血损伤模型,用药后检测各组大鼠Ⅱ导联心电图J点变化情况、心肌组织形态学变化、血流动力学变化及酶谱变化。

METHODS: Fortyfive aged healthy crossbred dogs (15±7) kg were divided into 3 groups: tetramethlpyrazine group, verapamil group and control group. The operation was performed to ligate the near part of the LAD through left minimal thoracic incision to block 75% of the blood flow respectively.

将45只犬分为川芎嗪,维拉帕米和对照组3组,结扎LAD阻断血流75%,分别测定3组结扎前及结扎后不同时段的分泌型P选择素、内皮素1(ET1)、一氧化氮及心肌肌钙蛋白T的含量变化,Western blotting法检测心肌组织Pselecntin基因表达情况。

METHODS: Fortyfive aged healthy crossbred dogs (15±7) kg were divided into 3 groups: tetramethlpyrazine group, verapamil group and control group. The operation was performed to ligate the near part of the LAD through left minimal thoracic incision to block 75% of the blood flow respectively. The expression changes of endothelium derived factors NO, ET1, sPselectin and CTnT before ligation and at different time points after ligation were detected and Pselectin gene of cardiac muscle was determined by Western blotting.

将45只犬分为川芎嗪,维拉帕米和对照组3组,结扎LAD阻断血流75%,分别测定3组结扎前及结扎后不同时段的分泌型P选择素、内皮素1(ET1)、一氧化氮及心肌肌钙蛋白T的含量变化,Western blotting法检测心肌组织Pselecntin基因表达情况。

METHODS: Fortyfive aged healthy crossbred dogs (15±7) kg were divided into 3 groups: tetramethlpyrazine group, verapamil group and control group. operation was performed to ligate the near part of the LAD through left minimal thoracic incision to block 75% of the blood flow respectively. The expression changes of endothelium derived factors NO, ET1, sPselectin and CTnT before ligation and at different time points after ligation were detected and Pselectin gene of cardiac muscle was determined by Western blotting.

将45只犬分为川芎嗪,维拉帕米和对照组3组,结扎LAD阻断血流75%,分别测定3组结扎前及结扎后不同时段的分泌型P选择素、内皮素1(ET1)、一氧化氮及心肌肌钙蛋白T的含量变化,Western blotting法检测心肌组织Pselecntin基因表达情况。

METHODS: Forty five aged healthy cross bred dogs (15±7) kg were divided into 3 groups: tetramethlpyrazine group, verapamil group and control group. The operation was performed to ligate the near part of the LAD through left minimal thoracic incision to block 75% of the blood flow respectively. The expression changes of endothelium derived factors NO, ET 1, sP selectin and CTnT before ligation and at different time points after ligation were detected and P selectin gene of cardiac muscle was determined by Western blotting.

将45只犬分为川芎嗪,维拉帕米和对照组3组,结扎LAD阻断血流75%,分别测定3组结扎前及结扎后不同时段的分泌型P 选择素、内皮素 1(ET 1)、一氧化氮及心肌肌钙蛋白T的含量变化,Western blotting法检测心肌组织P selecntin基因表达情况。

OBJECTIVE: It is hypothesized that arrhythmia can be treated by changing Cx levels and intervening abnormal GJ channel. Moreover, to explore the effects of bone marrow mesenchyma stem cells on the expression of Cx43 and Cx45 in rats with myocardial infarction.

目的:课题组假设通过改变缝隙连接蛋白水平、干预异常的GJ通道,来尝试治疗心肌梗死后心律失常,为此探讨同种异体骨髓间充质干细胞移植对心肌梗死大鼠缝隙连接蛋白43及缝隙连接蛋白45 mRNA表达的影响。

Surgical myotomy or coronary artery bypass graft and transaortic subvalvular myectomy should be reserved when patients are refractory to medical treatment.

心肌切开术或冠状动脉绕道手术及经主动脉瓣膜下心肌切除术应保留给内科治疗失败的病人。

Objective:To study the effect of spironolactone inhibiting proliferation on cultured myocardiac myofibroblasts and explore its possible mechanisms.

目的:研究螺内酯对培养的心肌成纤维细胞增殖的作用,揭示螺内酯抑制心肌纤维化的可能机制。

Cellular transplantation in treatment of myocardiac infarction is a new tactics,this article reviews the transplantation of muscle satellite cell and stem cell used in clinical study.

细胞移植是治疗心肌梗死的一种新策略,本文对目前应用于临床研究的骨骼肌卫星细胞移植及骨髓干细胞移植治疗心肌梗死的进展进行综述。

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