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结论在常规心力衰竭治疗的基础上加用曲美他嗪和通心络能改善缺血性心肌病心衰患者的心脏收缩功能。

Results: Thrombus within right ventricle and main pulmonary artery was detected in 6 patients, right atrium and RV enlargement was found in 19 patients, right ventricular hypokinesis was found in 21 patients, hypokinesis of interventricular septum was detected in 13 patients, MPA and right pulmonary arterial dilation was found in 22 patients, marked tricuspid regurgitation was detected in 23 patients, pulmonary hypertension was found in 23 patients.

右心异常改变者26例(包括超声直接检出血栓的6例),其中右房室增大19例;右室收缩功能减退21例;室间隔左移、左室短轴切面室间隔向左室膨突呈&D&型改变1例;室间隔运动幅度减低13例;主肺动脉及右肺动脉增宽22例;三尖瓣中量以上返流23例;肺动脉收缩压增高23例,范围在33~81mmHg (62.87±23.46 mmHg),治疗后肺动脉压明显下降,范围在21~52 mmHg (34.26±13.52 mmHg)。

The time to peak systolic longitudinal strain and the time to peak systolic radial strain were derived from the LV apical views , and to peak systolic circumferential strain was derived from the parasternal short axis. The standard deviation for time to peak longitudinal、circumferential and radial strain in the 18 segments (LS-SD18、CS-SD18、RS-SD18) and the maximal temporal difference of any two segments(LS-dif、CS-dif、RS-dif)were calculated as a strain-derived dyssynchrony index.

方法16例慢性心衰患者,获取心尖长轴观测量各节段收缩期纵向应变达峰时间,径向应变达峰时间,胸骨旁短轴观测环向应变达峰时间,计算CRT术后1个月、术后3个月18节段纵向、环向、径向应变达峰时间标准差(LS-SD18、CS-SD18、RS-SD18)、左室各节段收缩期纵向、环向、径向应变达峰时间最大差值(LS-dif、CS-dif、RS-dif)作为应变非同步指标。

objective trimetazidine has shown anti-ischemic properties to improve exercise tolerance without haemodynamic effects and direct cyto protective effect on the myocardium.however,it is not clear whether trimetazidine has beneficially effect on severe ischemic cardiomyopathy.methods 19patients(68±9)years with postnecrotic left ventricular dysfunction(ejection fraction31.7%±5.4%)were studied to examine the benefit of adding60mg a day of trimetazidine for3months to the classical therapy.the assessment included clinical evaluation,electrocardiography and echocardiography.results after adding60mg a day of trimetazidine for3months,attack of angina was relieved and dyspnea was improved(p.05).but heart rate,systolic blood pressure,rate pressure product,ejection fraction,left ventricular volume and global wall motion index were not changed.conclusion trimetazidine seems to improve clinical status while can not change oxygen supply-to-demand ratio without adverse effects in patients on severe ischemic carˉdiomyopathy.

目的 曲美他嗪是一种新型的抗心肌缺血的药物,能够改善患者的运动耐量和心肌的直接保护作用同时并没有血流动力学效应。但目前对于严重缺血性心肌病患者的临床治疗价值还需要进一步观察。方法 19例(68±9)岁确诊为缺血性心肌病(左心室射血分数0%)的患者在常规治疗的基础上加用每日60mg曲美他嗪治疗3个月,随诊观察患者临床情况以及超声心动图指标的变化。结果 19例患者均可耐受在常规治疗基础上加用每日60mg曲美他嗪的治疗,随诊发现患者心绞痛发作明显减少,运动耐量明显改善。同时患者心率、收缩压、心率血压乘积、左心室射血分数、左心室容量以及整体室壁运动指数无明显改变。结论缺血性心肌病的患者在常规治疗基础上加用曲美他嗪是安全的,同时其能明显改善患者的临床状态,而这种作用并不改变心肌氧的供求比值。

Results Compared with normal myocardium, the peaks of strain and strain rate curve of ischemic myocardium in systole and EF reduced. The postsystolic shortening wave appeared before operation.

结果 术前缺血节段心肌应变和应变率曲线中应变值和收缩期峰应变率值均小于健康人相应心肌节段并可出现收缩后收缩波;术后经治疗的缺血心肌各指标较术前明显增加,PSS波消失,术后左室射血分数有增加。

Results Compared with normal myocardium, the peaks of strain and strain rate curve of ischemic myocardium in systole and EF reduced. The postsystolic shortening wave appeared before operation. Each index increased and PSS wave disappeared after operation.

结果 术前缺血节段心肌应变和应变率曲线中应变值和收缩期峰应变率值均小于健康人相应心肌节段并可出现收缩后收缩波;术后经治疗的缺血心肌各指标较术前明显增加,PSS波消失,术后左室射血分数有增加。

LAA mechanical activity prior to ECV is highly related to maintenance of sinus rhythm in NVAF, and LAA "stunning" developed a thrombogenic milieu. Patients with atrial fibrillation should be given full anticoagulation to prevent thrombogenesis in left atrial and LAA.

NVAF患者电转复前左心耳收缩功能与窦性心律的维持高度相关;转复后左心耳&顿抑&,出现了血栓易于形成的条件,故对此类患者电转复后应给予足够的抗凝治疗,预防左房与左心耳血栓形成。

There was a good correlation between Ptw,AVCtw,MVOtw,PTV,PUV,UntwR and age.2.Assessment of left ventricular twisting and untwisting of DCM patients19 DCM patients(range 18-80 yr,mean age 50.52±17.52 yr,2 females) and 21 age- and sex-matched normal controls(range18-80 yr,mean age 49.05±16.94 yr,5 females) were enrolled into this study.Then DCM patients were divided into two groups:E/A<2 group and E/A>2 group.The routine echo showed the left ventricle dilated and EF decreased.The results show that LV rotation degree, rotation velocity at baseline and apex were irregular changeable with the cardiac cycle;the rotation direction was clockwise at the base and counterclockwise at the apex,and are combined to yield a systolic counterclockwise twisting as seen from the apex,but the rotation at the basal and apex were the same direction in some patients.

扩心病患者左室扭转及解旋特征的研究选择扩张型心肌病(Dilated Cardiomyopathy,DCM)组患者19例(男性17例,女性2例,年龄18~82岁,平均50.52±17.52岁),健康体检者21例(男性16例,女性5例,年龄18~80岁,平均49.05±16.94岁)作为对照组,扩心病患者按照E/A分为E/A<2、E/A>2两个亚组,结果显示:常规超声显示DCM组LVDd值增大,EF值减小;DCM患者左室心底部与心尖部心肌旋转角度、旋转速度随心动周期变化曲线明显紊乱;与正常组比较,DCM患者左室整体扭转角度和速度分别为(6.49±1.82)°、(67.84±15.60)°/s,较正常人显著减低P<0.01左室舒张末及收缩末扭转角度DCM患者较正常人显著减低(P<0.01,左室舒张末及收缩末时间在DCM-E/A>2组较正常人及DCM-E/A<2组显著缩短P<0.01DCM患者左室解旋速度较正常人亦显著减低(P<0.01,左室功能轻中度减低(DCM-E/A<2)患者解旋率[(0.29±0.07)%]较正常人[(0.42±0.11)%]明显减低,但当左室功能重度减低(DCM-E/A>2)时左室解旋率[(0.63±0.35)%]较正常人反而增加;左室整体扭转角度、舒张末扭转角度、收缩末扭转角度、解旋与左室射血分数未见明显相关性。3。

In HHD, diastolic insufficiency appears in early stage, and systolic dysfunction in late stage, the dilatation of left atrium and ventricle goes first followed by total cardiac enlargement in advanced stage.

甲亢病人左心室收缩功能增强。HHD病人早期出现左心舒张功能不全,收缩功能正常,晚期出现收缩功能不全。

Objective To investigate the serum levels of expression of MMP-2 and MMP-9 in SHF, CHF and control groups respectively for the purpose of approaching the internal relationship between MMP-2, MMP-9 and CHF. Through the way, we could further study whether MMPs can be regarded as a new target to evaluate the progressing as well as the treatment and prognosis of CHF.

目的 检测收缩性心衰及舒张性心衰患者和正常对照组血清中血清基质金属蛋白酶2,9的含量,探讨两种类型心衰与MMP-2,MMP-9表达的内在关系,从而进一步探讨MMP-2,MMP-9是否可作为心衰病情进展和评价心衰治疗效果及预后的新指标。

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