心律失常

Aim To observe the effects of ouabain and aconitine on APD and ion channels in isolated guinea pig and rat ventricular myocytes; to elucidate the action mechanisms of these two drugs and set up new arrhythmic models on cellular level.

目的 观察哇巴因和乌头碱对豚鼠和大鼠心肌单细胞离子通道的作用，确定两药诱发心律失常时离子靶点和最佳靶点，建立细胞水平的心律失常模型。

The changes of endocardium MAP combined with the blood serum myocardium enzyme assay to diagnose earlier myocardial ischemia and arrythmia is a reliable and fast method.

心律失常时心内膜MAP的特征性形态变化结合血清心肌酶指标是判断早期心肌缺血、心律失常的一种快速、可靠的方法。

HCN4 is as wrong as all sorts of rhythm of the heart the relationship is close, familial sex Dou Xingxin has eaten the transmissibility rhythm of the heart such as delay show outside gene of wrong patient HCN4 child alkaline base be short of break or the change that bump changes mutation to bring about HCN4 passageway albumen, cause If extent to decrease, belong to euchromosome dominance heredity.

HCN4和各种心律失常关系密切，家族性窦性心动过缓等遗传性心律失常患者HCN4基因外显子碱基的缺失或颠换突变导致HCN4通道蛋白的改变，引起If幅度减少，属于常染色体显性遗传。

Using interclass correlation analysis andcorrelation coefficient to demonstrate the relationship betweenventricular premature beat and other ventricular arrhythmia,supraventricular premature beat and other atrial arrhythmia.

应用相关分析方法，依据相关系数，分析室性早搏与其他类型室性心律失常，室上性早搏与其他类型房性心律失常之间的关系。

Based on the latest achievements of the mechanism of peradaptation to myocardium ischemia and pharmacodic preadaptation up to date, observations were made on 80 patients of acute myocardial infarction to assess the enzymatic dynamics of myocardium, symptoms after myocardial infarction occurred like cardiac rhythm abnormality, anginapectoris, heart failure, cardiogenic shock, reinfarct and the mortality in the hospital. The results indicated that peradaptation to myocardium ischemia is of significance in protecting myocardium, reducing the areas of infarction, abating the cardiac insufficiency after infarction and reducing the abnormality of heart rhythm and significantly ameliorating the prognosis.

本研究结合现代医学对心肌缺血预适应机制及药理性预适应作用的最新研究成果和动向，通过临床观察80例急性心肌梗死患者的心肌酶学变化，心律失常、梗死后心绞痛、心力衰竭、心源性休克、再次梗死等心肌梗死后并发症和住院病死率，证实缺血预适应具有保护心肌，缩小梗死范围，减轻梗死后心功能不全及减少心律失常的作用，可明显改善心肌梗死病人的预后。

As the variation of QRS complex wave is the primary reference criteria on clinical diagnosis of arrhythmia, exact extraction of the features of QRS complex wave is the key problem.

QRS复合波群的形态变化是心律失常临床诊断的重要参考标准，因而准确地提取QRS复合波群的波形特征是心律失常自动化诊断中面临的关键问题。

It was available that the method of pressing and threshing on precardiac region was used in the cardiac sudden death resulting from cardiac dysrhythmia and torpidity cardiac dysrhythmia.

快速性心律失常与缓慢性心律失常引起的心源性猝死用胸前捶击及胸外按压方法抢救是有效的。

Fleshy of heart failure, cardiac muscle, atrium is vibratile wait for acquired character rhythm of the heart the attune on the expression of gene of wrong patient HCN4, can make If increases, cause rhythm of the heart wrong happening.

心力衰竭、心肌肥厚、心房颤抖等获得性心律失常患者HCN4基因的表达上调，可以使If增大，导致心律失常发生。

There is evidence that patients with sleep apnea syndrome have higher mortality from cardiovascular causes than nonapneic individuals. One possibility that might explain this association may be increased prevalence of cardiac arrhythmia in apneic patients.

睡眠呼吸暂停综合征患者中心血管疾病的发病率和死亡率增加，一个可能的原因就是SAS患者中心律失常尤其是缓慢型心律失常的发病率增加，这主要与SAS患者睡眠期间发生呼吸暂停时心脏节律的周期性改变有关。

Methods The experimental arrhythmia models were induced with barium chloride (BaCl2),uabaina and aconitine in rats and cobayaes.The incidence rate and mortality rate of arrhythmia,the emergence time and the duration of arrhythmia induced with BaCl2 were recorded in rats pretreated with CASI (in dosages of 25,50, and 100 mg·kg-1 sublingual vein injection).At the same time,the dosages of uabaina and aconitine were observed when the ventricular premature contraction,ventricular tachycardia,ventricular fibrillation and cardiac asystole were appeard in rats and cobayaes pretreated with CASI (in dosages of 25,50, and 100 mg·kg-1 sublingual vein injection).

制备氯化钡(BaCl2)、哇巴因及乌头碱诱导的大鼠及豚鼠实验性心律失常模型，CASI按25、50、100 mg·kg-1分为3个剂量组，舌下静脉给药1次，不给CASI作为对照组，记录大鼠给BaCl2后心律失常的发生率、出现时间、持续时间及动物的死亡率；观察豚鼠及大鼠出现室性早搏、室性心动过速、心室颤动及心脏停搏时哇巴因及乌头碱的用量。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。