心律失常

CASI have a significantly protective effect on experimental arrhythmia induced with medicine in rats and cobayaes,its effect on calcium channel is more better than on natrium channel.The results show that CASI may be calcium channel blocker.

CASI对多种药物诱发的实验性心律失常均具有明显保护作用，其对抗Ca2+性心律失常的作用明显优于Na+性心律失常，提示CASI可能为钙通道阻滞剂。

Made arrhythmia models of rats by injecting digitoxin,then treated then by injecting nifedipine and compared then with phenytoxin sodium group. Result Nifedipine can not cure arrhythmia,instead making it worse.

注射洋地黄建立大鼠心律失常模型，分别注射硝苯地平治疗，并与注射苯妥英钠组进行比较结果：硝苯地平不能治疗心律失常，反而使心律失常加重。

The result indicated that HSC could obviously cut down the occurrence of rentricular vibration induced by chloroform in mice,lengthen the time of arrhythmia appearance,shorten the time of arrhythmia continuum and conversion induced by barium chloride in model rats,it also could shorten the time of ventriclar extrasystole and ventricular tachycardia in model rats induced by aconitine.

结果表明：黄松胶囊能明显降低氯仿所诱发小鼠室颤的发生，明显延长氯化钡模型大鼠心律失常出现时间，缩短模型大鼠心律失常持续和复律时间，尚能明显缩短乌头碱性大鼠心律失常的室性早搏及室性心动过速持续时间，与模型对照组比较均有统计学差异。

Methods Animals were randomly and equally divided into five groups: saline control group, positive drug control group, low-dose, medium-dose and high-dose crocetin group. Animals were anesthetized with urethane (1.2 g/kg), then followed by the perfusion of aconitine (10 μg/mL) through caudal vein in rats, or of ouabain (9 μg/mL) through external jugular vain in guinea pigs in a constant velocity of 0.1 mL/min, and the emergence time of ventricular fibrillation, ventricular extrasystole, ventricular tachycanlia and cardiac arrest were then detected and recorded. The recorded time was then translated to the cumulated amount of aconitine and ouabain. Experimental arrhythmia was induced by rapid injection of 4% CaCl2 (140 mg/kg), and the emergence time, persistence time, incidence and death of arrhythmia after the administration were observed.

将实验动物随机分为生理盐水组，阳性药物对照组，藏红花酸高、中、低剂量组，SD大鼠采用1.2 g/kg乌拉坦麻醉后，从尾静脉匀速(0.1 ml/min)灌注10μg/ml乌头碱溶液，豚鼠麻醉后从颈静脉匀速(0.1 ml/min)灌注9μg/ml哇巴因溶液，观察出现室性期前收缩、室性心动过速、室颤和心脏停搏的时间，然后换算成乌头碱和哇巴因的累积量；快速推注4%氯化钙(140 mg/kg)诱导大鼠心律失常，观察给药后心律失常出现时间、持续时间、心律失常发生数及死亡数。

Results According to the reduction of the standard deviation of nomal-to-norml intervals in the entire 24 hour ECG recording, the severely arrhythmias including Lown's grade≥3 ventricular arrhythmias and atrial tachycardias and fibrillation were increased.

结果 糖尿病患者严重的心律失常如Lown's≥13级的室性心律失常及房性心律失常随SDNN（24h内全部正常R-R间期的标准差）降低而明显增加。

Sleep Apnea Syndrome is associated with cardiovascular autonomic nervous abnormalities. Hypertensive subjects are characterized by lower HRV than controls at rest. Sympathetic activity increased during nocturnal apneic episodes, which may mediate the cardiovascular complications of sleep apnea.

本研究显示，在SAS患者中心律失常尤其是缓慢型心律失常的发生率增高，并与夜间低氧血症和呼吸暂停的严重性有关，这就提醒我们在对心律失常的诊断和治疗过程中，也应该考虑到SAS的存在。

At the BCL of 500ms, 1000ms and 2000ms,the VWtimes increased markedly with the BCL prolonging, and the degree of increasing was even obviously when heart rate was slow (BCL=2000ms or 1000ms). The enlargement of VWs was a most important reason to increase the incidence of ventricular arrhythmias; 2）At the BCL of 500ms, 1000ms or 2000ms,the VWtimes of the premature stimulates S2 was at endomembrane were wider than at the outermembrane. We supposed that premature stimulates come from endomembrane was easier inducing VF compared with outermembrane;3The VWtime of unidirectional block was wider than reentry's, we can see that reporlarization dispersion changed dynamicly. 4The QRS polar of the premature stimulates was opposite the primary beats ,which suggesting that excitation of inducing premature beats was coming from epicardial. That is to say electrotonic potential take part in the creation of reentry;5With the ratio of the Tp-e/QT increasing the occurrence of VF was upgrading. So the ratio was an effective method to estimate the event of SCD.6 The VWtimes of S3 were broaden than S2's. But we can not study penetratingly, which is the contents of our future studies.

在BCL为500ms、 1000ms和2000ms刺激条件下，随着刺激周长的增加单向传导阻滞时间易损窗呈增大趋势；并且在心率较慢时(BCL为2000ms和1000ms)增大最明显，是LQTS患者室性心律失常发生率增加的原因之一；2）在BCL为500ms、 1000ms和2000ms刺激条件下，S2位于内膜侧时时间易损窗大于在外膜侧时的，推测来自于内膜侧的期前刺激易于诱发室性心律失常；3）折返激动时间易损窗小于在单向传导阻滞时间易损窗，折返易发生于S2刚进入单向传导阻滞区间时，这说明复极梯度的不均一是动态变化的；4心电图上倒置QRS波与正常S1刺激所引起QRS波极性相反，提示不同位置S2刺激引发的室性早搏的兴奋均来自于外膜侧，说明了电紧张电位扩布参与了折返的产生；5）Tp－e/QT可以反应跨膜复极离散度，随着Tp－e/QT比值的增加PVT的发生增多，其可以用来预测室性心律失常的发生。6）随着期前刺激数目的增加时间易损窗增大。

Methods Sixty wistar mouse were ransdomed into six groups, aconitine evocate arrhythmia, and continuously observe the changes of electrocardiogram and record the latent period, the lasting time of the arrhythmia and the death rate.

采用乌头碱诱发Wistar大鼠心律失常，持续观察心电图变化直至出现心律失常，记录心律失常的潜伏期、持续时间及死亡率。

objective to study the effect of qingshanjianxin tablet on treating arrhythmia.methods sixty wistar mouse were ransdomed into six groups, aconitine evocate arrhythmia, and continuously observe the changes of electrocardiogram and record the latent period, the lasting time of the arrhythmia and the death rate.results qingshanjianxin tablet can prolong the latent period of the arrhythmia, shorten the lasting time of arrhythmia and lower the death rate.

目的 研究青山健心片抗心律失常的作用机制。方法采用乌头碱诱发wistar大鼠心律失常，持续观察心电图变化直至出现心律失常，记录心律失常的潜伏期、持续时间及死亡率。结果青山健心片高、中剂量组均能延长心律失常的潜伏期，缩短心律失常的持续时间，降低死亡率，与心律平片组无明显差异(p＞0.05)，疗效优于低剂量组、空白对照组、心律宁片组(p＜0.05)，高剂量组与中剂量组之间无显著差异(p＞0.05)。

Base on the result, a new antiarrhymic drug model was established, and the molecular mechanism was clarified why matrine and berbamine were not so effective on arrhythmia compared to amiodarone and RP58866. The antiarrhythmic mechanism of Chinese traditional drugs cyclovirobuxine D and water extracts from codyceps sinensis was investigated, and a scheme was produced to potentize the afficacy of antiarrhythmic Chinese traditional drugs.

在此基础上，建立了一种新的抗心律失常药物模型，阐明苦参碱和小檗胺抗心律失常作用弱于胺碘酮和RP58866的分子机制；并探讨了中药环维黄杨星D、冬虫夏草水提液抗心律失常作用机制，提出了增强抗心律失常中药效能的方案。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。