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Through the multiple stepwise regression analysis, the duration of the disease and serum GH level were the main influencing factors of acromegalic cardiomyopathy. 2 Ejection fraction and fractional shortening, were decreased, compared to control group, they still remained in normal range. 3 Isovolumic relaxation time and E wave descending time, were delayed apparently compared to control group, indicating the damage of cardiac relaxation. 4 Subgroup analysis in acromegalic: The comparison between patients with diabetes mellitus and impaired glucose tolerance and patients without DM/IGT showed that there was no significant difference in terms of the parameters in the two groups, in spite of an mild increase of IVST in the former group.

经多元逐步回归分析,病程和血清生长激素浓度为心肌肥厚的主要影响因素。2实验组射血分数和左心室短轴缩短率虽较对照组低,但仍在正常范围。3实验组左心室等容舒张时间和二尖瓣减速时间较对照组明显延长。4实验组中继发糖尿病/糖耐量减低组与非DM/IGT组进行比较,前者仅室间隔有较明显增厚,其余各项参数2组间差异均无统计学意义。

Observational studies suggest that conventional right ventricular apical pacing may have a deleterious effect on left ventricular function.

观察研究表明传统的右心室心尖起搏可能对左心室功能有害。

Results There was no apparent gender difference among 14 patients. 9 patients were younger than 30 years old. Pathological examination showed that bronchial infiltration of eosinophils in 14 patient (100%), thickened basement membrane of the bronchial mucosa in 12 patients (85.7%), proliferation of smooth muscle cells in 11 patients (78.6%), proliferative mucous gland in 9 patients (64.3%), mucous plug in bronchiole in 8 patients (57.1%), and cicatvization of left ventricle in 10 patients (71.4%).

结果哮喘猝死患者无性别差异,年龄30岁以下者9例(64.3%);病理改变的特点为支气管管壁嗜酸细胞浸润14例(100%),粘膜基底膜增厚12例(85.7%),支气管平滑肌细胞增生11例(78.6%),粘液腺增生、肥大9例(64.3%),细支气管内粘液栓形成8例(57.1%);左心室壁瘢痕形成10例(71.4%),病变主要位于左心室侧壁和心尖部。

Results ① Vs of left ventricle and interventricular septum had not difference, and was lower than that of right ventricle.

结论心室壁的运动是同步的,但左右心室壁及心室内各个部位的运动不是同时的。

Methods:32 patients of TCPC were reviewed: the average age was 10 years,ranged from 5 to 24 years and the average weight was 28 kilogramme,ranged from 13 to 55 kilogramme.18 patients underwent lateral tunnel and 1 patient underwent extracardiac conduit TCPC with hypothermic cardiopulmonary bypass and heart arrest,and 10 patients were treated by extracardiac conduit technique with normothermic CPB and without heart arrest and 2 patients without CPB,and 1 patients underwent two-step operation.

回顾性分析32例全腔静脉肺动脉连接术患者的临床资料:年龄5~24岁,平均(10±5)岁,体重13~55 kg,平均(28±11) kg,病种包括单心室16例,右心室双出口并完全性心内膜垫缺损6例,完全性大动脉转位并完全性心内膜垫缺损3例,三尖瓣闭锁6例,二尖瓣闭锁1例。其中,在低温体外循环心脏停跳下18例行右房内侧隧道法,1例行心外管道法,常温体外循环心脏跳动下10例行心外管道法,非体外循环下2例行心外管道法,1例行分次全腔静脉肺动脉连接术。

RESULTS: Compared with NS control group, the ratio of HW/BW, LVW/BW and the content of hydroxyproline, AngⅡ, MDA and iNOS activity in the left ventricle were significantly increased. The cNOS, SOD, GSH-Px activities and NO content were obriously decreased in the ISO model group. After treatment with PNS, the left ventricular NO content, cNOS, SOD and GSH-Px activities were markedly higher than those in ISO model group. The content of MDA, AngⅡ and iNOS activities and the ratio of HW/BW, LVI were significantly lower than those in ISO model group.

结果:ISO模型组大鼠的HW/BW、LVI、左心室HyP、AngⅡ、MDA含量和诱生型NOS活性显著高于生理盐水对照组,SOD、GSH-Px及结构型NOS活性和NO含量明显比生理盐水对照组低;PNS治疗组左心室心肌组织中NO含量、cNOS、SOD和GSH-Px活性明显高于ISO模型组;MDA和AngⅡ含量及iNOS活性和心脏重量指数比ISO模型组低。

The primary end point was the incidence of atrial fibrillation. The second end points were New York Heart Association cardiac function class, changes in left atrial and left ventricular end-diastolicdiameters, as well as left ventricular ejection fractionmeasured by echocardiography.

主要研究终点为房颤的发生率,次要终点为心功能分级及超声心动图检查指标(左心房内径、左心室舒张末期内径、左心室射血分数)。

The examined subjects were asked to carry out Muller maneuver slowly so that the intrathoracic pressure decreases gradually while the blood flow of the right ventricular outflow tract observed with pulsed Doppler echocardiography at the parasternal short-axis view of the great vessels in the two-dimensional echocardiography.

结果 1。模拟实验胸压变化对血流动力学的影响 3 第四军医大学博士学位答辩论文外周静脉压和模拟胸腔压力变化相同时所引起的右心室容积的变化是相同的;当两者同时同步变化时,右心室容积无变化。模拟胸腔压力变化时,模拟肺血管床和左心室内压力同等程度变化。

objective trimetazidine has shown anti-ischemic properties to improve exercise tolerance without haemodynamic effects and direct cyto protective effect on the myocardium.however,it is not clear whether trimetazidine has beneficially effect on severe ischemic cardiomyopathy.methods 19patients(68±9)years with postnecrotic left ventricular dysfunction(ejection fraction31.7%±5.4%)were studied to examine the benefit of adding60mg a day of trimetazidine for3months to the classical therapy.the assessment included clinical evaluation,electrocardiography and echocardiography.results after adding60mg a day of trimetazidine for3months,attack of angina was relieved and dyspnea was improved(p.05).but heart rate,systolic blood pressure,rate pressure product,ejection fraction,left ventricular volume and global wall motion index were not changed.conclusion trimetazidine seems to improve clinical status while can not change oxygen supply-to-demand ratio without adverse effects in patients on severe ischemic carˉdiomyopathy.

目的 曲美他嗪是一种新型的抗心肌缺血的药物,能够改善患者的运动耐量和心肌的直接保护作用同时并没有血流动力学效应。但目前对于严重缺血性心肌病患者的临床治疗价值还需要进一步观察。方法 19例(68±9)岁确诊为缺血性心肌病(左心室射血分数0%)的患者在常规治疗的基础上加用每日60mg曲美他嗪治疗3个月,随诊观察患者临床情况以及超声心动图指标的变化。结果 19例患者均可耐受在常规治疗基础上加用每日60mg曲美他嗪的治疗,随诊发现患者心绞痛发作明显减少,运动耐量明显改善。同时患者心率、收缩压、心率血压乘积、左心室射血分数、左心室容量以及整体室壁运动指数无明显改变。结论缺血性心肌病的患者在常规治疗基础上加用曲美他嗪是安全的,同时其能明显改善患者的临床状态,而这种作用并不改变心肌氧的供求比值。

Two of these pump blood to the lungs, where it picks up oxygen, then the other two pump this oxygenated blood throughout the body. One of these four chambers—the left ventricle—contracts most strongly to pressurise the blood.

相比之下,人的心脏只有四个心室,其中的两个心室收缩将血液压进动脉输送到肺部,在那里吸收氧气,放出二氧化碳,而另两个心室则将完成气体交换后的血液输送到到全身。

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