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Prior to the 17th century it was made of wood or wool in a leather cover.

球:我们试图击进洞里的圆形物体。17世纪之前,球用木头或羊毛制成。17世纪后,人们把羽毛煮沸、压缩,然后缝制在皮封面内。19世纪50年代发展成古塔胶球(或与杜仲胶其它物质的混合物),20世纪,这种球的核心包覆条状橡胶。

CaN Aβ gene silencing can reduce myocardial hypertrophy in cultured cells, si1280 (21bp) of CaN Aβ gene is the most effective target site for siRNA. The method of intrapericardial injection of plasmid, microbubbles and erzymes can improve transfection efficiency of non-viral plasmid with satisfying targeted transfection. But the scope of transfected myocytes is still limited. CaN Aβ shRNA expressing plasmid transfection in vivo by pericardial injection results in decreased CaN Aβ protein expression of small part of myocytes, and CaN Aβ mRNA only shows decreased trend. The dosage of non-viral vector and the parameters of ultrasound energy should be optimized in further study.

结论RNAi技术抑制CaN Aβ基因表达可有效减轻Ald诱导的心肌细胞肥大程度;CaN Aβ基因中si1280(21bp)片段为实现RNAi的更有效片段;微泡+酶类心包腔内注射超声导入的方法可有效改善非病毒载体在体心肌的转染效率,同时具有一定的靶向性,但总的转染范围仍然有限;采用这一方法进一步进行&一肾一夹&心肌肥大模型大鼠在体心肌细胞的CaNAβ的RNAi干预,发现心肌肥大大鼠心外膜下局部心肌细胞CaN Aβ蛋白水平降低,CaN AβmRNA水平虽有下降趋势,但无统计学差异,提示质粒的用量及超声导入的参数有待进一步研究使其优化。

Skeletal muscle ventricle constructed from conditioned skeletal*muscles, lined with autogenous or bovine pericardium, and connected with valved homografts between right atrium or venae cava and main pulmonary artery, has been demonstrated to be nonthrombogenic.

经耐疲劳训练的自体骨骼肌,内衬自体心包制成骨骼肌心室,并以同种带瓣主动脉吻合于右心房或上、下腔静脉与肺动脉之间来代替或辅助右心室的功能,可提高肺动脉收缩压及肺动脉血流并使之成为波动性,而且具有不需抗凝,无血栓形成等优点。

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