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Methods: Sprague Dawley rats have been used as recipients and Wistar rats as donors. Donor aorta was anastomosed to the recipient's suprarenal abdominal aorta; donor pulmonary artery was anastomosed to the left renal vein of the recipient using continuous suture technique.

以Wistar大鼠为供体,SD大鼠为受体,将供心的主动脉和肺动脉分别与受体肾血管上方的主动脉和左肾静脉用连续缝合技术行端侧吻合。

A total of 50 couples allogene rats were performed same proceeding like that.

供体经过肝素化后,在0~4℃条件下取心肺,并作适当修剪,最后在0~4℃条件下将心肺供体SD大鼠的主动脉与受体Wistar大鼠的颈总动脉行端侧吻合,并进行心肺复苏。

Methods and Results— Between March 2000 and October 2008, 70 fetuses underwent attempted aortic valvuloplasty for critical aortic stenosis with evolving hypoplastic left heart syndrome.

方法和结果-在2000年3月至2008年10月期间,给70名胎儿尝试行主动脉瓣成形术治疗伴有进展性左心发育不全综合征的严重主动脉瓣狭窄。

Results]All 18 cases were observed the real and the false cavity satisfiedly in two kinds of scanning.

结果]18例患者MSCT主动脉全程增强扫描均满意观察到真、假腔的大小、范围、主要分支是否受累。18例采用心电门控扫描显示胸廓入口至主动脉裂口水平的主动脉真假腔与全程增强扫描一致。

After administration of L-N〓-nitro-Arginine, a specific antagonist of NOS, it was found that the basal and stimulated NO release of blood vessels (aorta, internal carotid, renal and mensenteric artery) was decreased further. The increase of coronary blood flow stimulated by Ach was also reduced further, while the platelet aggregation degree and erythrocyte aggregation index increased significantly. Pathological examination indicated that aortic endothelium was destroyed, the blood vessels in cerebral, cardiac and renal tissues were hypertrophied further and some were almost occluded. The above fin dings resulted in SHR feeded with L-NNA having high incidence of stroke rate and high degree of renal cirrhosis when compared to control SHR. The infarct and hemorrhagic focuci in cerebral tissues, infarct focuci in cardiac tissues, atrophy and hyalinedegeneration of renal glomeruli and degeneration even necrosis of renal tubuli in renal tissues were al so found. The increase ratio of brain and heart to body weight and decrease ratio of kidney to body wei ght further demonstrated that the cerebral, cardiac and renal injuries were aggravated.

在上述结果的基础上进一步给予SHR NOS特异性拮抗剂左旋亚硝基精氨酸后,血管(胸主、颈内、肾及肠系膜动脉)NO基础释放及激动剂刺激释放进一步减少,Ach刺激冠脉流量的增加和胸主动脉内膜NOS活性也进一步减少,血小板聚集程度及红细胞聚集指数显著上升,病理切片显示胸主动脉内皮细胞破坏明显,脑心肾组织内的血管进一步增厚甚至几乎阻塞,导致饲L-NNA的SHR缺血性及出血性脑卒中发生率显著高于对照SHR,脑体重比显著升高;心肌内出现明显的缺血梗塞疤痕灶,心体重比显著升高;肾小球明显萎缩、玻璃样变性,肾小管也变性甚至坏死,使肾硬化程度显著增加呈颗粒性固缩肾,肾体重比也显著减少。

Results The main structure of the left ventricle in canine was composed of the mitral complex、aortic valve、falsetendons and so on,among them the mitral complex was included in the mitral ring and valve,chordae tendinease and papillary muscles;the circle of mitral ring was 49.16±10.00mm,the average heights of inside and outside valves were 14.28±3.14mm,9.27±1.99mm,respectively,the breadth were 25.74±5.21mm、21.50±6.33mm;the average number of chordae tendineass was 16.72±2.76;the average number of left ventricular false tendon was 4.69±3.38:the circle of aortic valve ring was 34.55±8.00mm,the average heights of left、right and back aortic valves were 6.85±1.76mm、7.19±1.75mm and 7.52±1.79mm.

结果:犬心左心室主要结构有二尖瓣复合体、主动脉瓣、假腱索等,其中二尖瓣复合体由瓣环、瓣膜、腱索、乳头肌构成;二尖瓣瓣环周径为49.16±10.00mm,内侧瓣、外侧瓣的高度分别为14.28±3.24mm、9.27±1.99mm,其宽度分别为25.74±5.21mm、21.50±6.33mm;腱索总数平均为16.72±2.76条;假腱索总数平均为4.69±3.38条;主动脉瓣瓣环周径为34.55±8.00mm,左瓣高度、右瓣高度和后瓣高度分别为6.85±1.76mm、7.19±1.75mm和7.52±1.79mm。

Conclusions— Technically successful aortic valvuloplasty alters left heart valvar growth in fetuses with aortic stenosis and evolving hypoplastic left heart syndrome and, in a subset of cases, appeared to contribute to a biventricular outcome after birth.

结论-主动脉瓣成形术技术上的成功改变了主动脉瓣狭窄及进展性左心发育不全综合征胎儿的左心瓣膜生长,在亚组病例中,似乎可造成生后双心室。

These include: the pre-VAD insertion examination of the heart and largevessels to exclude significant aortic regurgitation, tricuspidregurgitation, mitral stenosis, patent foramen ovale, or othercardiac abnormality that could lead to right-to-left shunt afterleft VAD placement, intracardiac thrombi, ventricular scars,pulmonic regurgitation, pulmonary hypertension, pulmonary embolism,and atherosclerotic disease in the ascending aorta; and to assessright ventricular function; and the post-VAD insertion examinationof the device and reassessment of the heart and large vessels.

这些包括:(1) VAD 植入前心脏和大血管的检查以排除明显的主动脉反流、三尖瓣反流、二尖瓣狭窄、卵圆孔未闭或者可能引起左 VAD 植入后右向左分流的其他心脏异常,心内血栓、心室疤痕、肺动脉反流、肺动脉高压、肺栓塞和升主动脉粥样硬化疾病;并且评估右室功能;(2) VAD 植入后检查设备及再评估心脏和大血管。

Which are this: my mother, who is not quite 85, has aortic stenosis, a narrowing of the heart's aortic valve, and her cardiologist has just told her that it's time now to think about open-heart surgery to replace the valve.

正是这一点:我的母亲,还不到85 岁,患有主动脉瓣狭窄,缩小心脏的主动脉瓣,她的心脏病就意味着,是时候做心内直视手术了以取代阀门。

And rheumatic valves also accounted for 70 cases (88.5%) of aortic stenosis plus insufficiency. The rheumatic valves was decreased dramatically as the cause of the aortic valve disease, aortic root dilation and degenerative valves increased significantly, while others had no significant changes.

随着社会进步和人口老龄化,风湿性病因所占比例大幅下降,主动脉根部扩张导致的主动脉关闭不全有较大幅度的上升,退行性主动脉瓣有所上升,二叶式主动脉瓣、感染性心内膜炎所致瓣膜损害变化不明显。

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