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This study established a LC-MS/MS method for the determination of squamocin and bullatacin, and calculated their enzyme kinetics in rat microsome.

[目的]建立番荔枝内酯类化合物squamocin和bullatacin的液相色谱串联质谱检测方法,并测定其在大鼠肝微粒体中的酶动力学参数。

METHODS: Using phenacetin as a substrate probe, the effects of Wuji Pill with different compatibility (No.1-9) on the enzymatic activity of CYP1A2 were detected by high-performance liquid chromatography.

按L9(34)正交表,戊己丸的配比设计为9个受试复方,以非那西丁为探针药, HPLC检测戊己丸对大鼠体外肝微粒体CYP1A2酶活性的影响。

CPZ and TFP inhibited ethylene-induced increase in activity of Ca〓-ATPase located in microsomal membrane in tomato and strawberry fruit, which indicated that 1 CaM involved in inducing of ethylene on Ca〓-ATPase; 2 the enzyme was regulated by CaM.

钙凋素拮抗剂CPZ和TFP能抑制乙烯诱导番茄果实和草莓果实微粒体膜Ca〓-ATPase活性,这表明CaM参与乙烯对该酶的诱导以及该酶活性受CaM的调节。

CYP3A4 (32%) is the most abundant CYP in Chinese liver microsomes, and the levels of CYP2C9 (19%) and CYP1A2 (16%) were also considerable.

CYP3A4(32%)是中国人肝微粒体中含量最丰富的CYP,而CYP2C9(19%)和CYP1A2(16%)的表达水平也相当可观。

The result indicated that the zircon saturation temperatures for host granodioriterange in 762~773oC,the average is 769oC,and the zircon saturation temperatures for mafic microgranular enclaves range in 752~770oC,the average is 760oC.

计算结果表明,阳坝花岗闪长岩的锆石饱和温度介于762~773oC,平均值为769oC,暗色微粒包体的锆石饱和温度介于752~770oC,平均值为760oC。

These results indicate that cabbage phenolic extract and single phenolic acids,i.e.Ferulic acid,Sinapinic acid and Gallic acid,etc.

研究表明,卷心菜提取物以及单个酚酸(儿茶素、阿魏酸和香豆酸)可以抑制〓、〓—7,8—二氢二醇和四氯化碳在肝微粒体作用下的代谢,降低主要代谢产物〓—7,8—二氢二醇、〓—7,8—二氢二醇—9,10一环氧化物和丙二醛的生成量。

In addition, our data suggest that norpregnane derivatives may be thrombogenic, whereas micronized progesterone and pregnane derivatives appear safe with respect to thrombotic risk.

另外,我们研究表明非孕烷衍生物可能具有血栓形成性,而微粒化的黄体酮和孕烷衍生物相对于血栓形成似乎是安全的。

At last,the optimized formula composition and technique of preparation were obtained by orthogonal design,and long-circulating praziquantel liposome was prepared.

在建立吡喹酮含量测定方法的基础上,通过葡聚糖凝胶柱色谱法、显微镜法、激光散射法等定性及定量方法考察脂质体的包封率、微粒外观、粒径及其分布等指标。

Phenobarbital does not impair normal hepatic function but has been shown to induce liver microsomal enzymes, thus increasing and/or altering the metabolism of barbiturates and other drugs.

苯巴比妥不损害肝脏的功能,但可诱导肝微粒体酶,从而增加或改变巴比妥类和其他药物的代谢。

Through a multidimensional compared to prove the feasibility and reliability of in vitro drug metabolism platform of human and rat liver microsomes.

通过多方面的比较,证明了本研究建立的人、鼠肝微粒体体外药物代谢平台的可行性和可靠性。

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The split between the two groups can hardly be papered over.

这两个团体间的分歧难以掩饰。

This approach not only encourages a greater number of responses, but minimizes the likelihood of stale groupthink.

这种做法不仅鼓励了更多的反应,而且减少跟风的可能性。

The new PS20 solar power tower collected sunlight through mirrors known as "heliostats" to produce steam that is converted into electricity by a turbine in Sanlucar la Mayor, Spain, Wednesday.

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