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On the other hand, the hepatic microsomal aminopyrine demethylase activity was obviously inhibited 2 hours after administration of the same dose of SY-801 and SY-640, while the content of hepatic cytochrome P-450 was not affected.

体外实验表明,SY-801和SY-640对正常小鼠、3-甲基胆蒽(3-MC)处理小鼠及苯巴比妥处理小鼠小鼠肝微粒体氨基比林脱甲基酶活性都具有明显的抑制作用,其中对3-MC处理小鼠肝微粒体氨基比林脱甲基酶活性抑制作用最显著。

The weight and protein content of the microsomes from different evolutionary animal and tissue cells were first determined, and the weight of microsome varies obviously and the protein content of microsome in unit is almost the same.

本文还首次系统比较了不同组织细胞和不同进化程度动物细胞的微粒体获得率及蛋白含量,得到了不同细胞微粒体获得率明显不同、单位重量微粒体蛋白含量却基本相同的结果,表明不同细胞ER含量不同,而单位ER内蛋白含量基本相同。

We employed HPLC to measure the metabolites of caffeine in the whole blood and calculated the ratio be between the metabolite and caffeine, which was used as index to evaluate the effect of Qingkailing injection on rat CYP1A2 activity in vivo ; We also detected the CYP1A2 and CYP2D6 activity in microsomal reconstituted system by analysis of phenacetin metabolism and dextromethorphan metabolism with HPLC.

通过HPLC法测定全血中咖啡因的代谢率,观测清开灵注射液对大鼠CYP1A2活性的影响;通过HPLC法测定大鼠肝微粒体重组系统非那西丁的代谢比率,确定清开灵注射液对大鼠肝微粒体CYP1A2亚型的作用;测定大鼠肝微粒体重组系统右美沙芬的代谢比率,确定清开灵注射液对大鼠肝微粒体CYP2D6亚型的作用。

In addition, the dose-response experiment of hepatic EROD in porgy induced by 0# disel oil WAF was studied to dsicuss the possibility to use it as a biomarker for monitoring environmental pollution.

另外,也初步开展了黄鳍鲷肝微粒体EROD的剂量—效应研究,探讨了这种鱼肝微粒体EROD酶作为污染监测指标的可能性。

Furthermore, taurine-treated microsomes showed a higher incorporation of radiolabled oleoyl-CoA into diacylglycerol, phosphatidylethanolamine, sphingomyelin and lysophosphatidylcholine lipid fraction in comparison with the control microsomes.

牛磺酸可改变微粒体膜脂质成分(如降低游离胆固醇、磷脂酰丝氨酸和鞘磷酸,升高磷脂酰乙醇胺和磷脂酸的浓度)和膜磷脂脂肪酸成份,并降低微粒体膜脂质的流动性。

Methods Beagle dog liver microsomes were prepared by using ultracentrifuge method. After incubating 0.4 μmolL^(-1) MN9202 with 1 gL^(-1) microsomes for 30 min at 37℃, the reaction was terminated by adding 0.5 mL alkalization. The RP-HPLC was used to determine the drug in the incubation mixture.

差速离心法制备Beagle犬肝微粒体酶,0.4μmolL^(-1)的MN9202与1.0gL^(-1)的肝微粒体酶在37℃水浴中孵育30min,加入0.5mL碱化液终止反应,然后采用RP-HPLC法测定孵育液中MN9202原形药物的浓度。

According to the macro-characteristics and distribution law of dioritic microgranular enclaves, the special texture and structure, the contrast between the main rock-forming minerals of dioritic microgranular enclave and the host rock, as well as the genesis analysis on double crystal type percentage of 6 187 plagioclase, the conclusion is drawn as follows: despite the variety of the genesis types of dioritic microgranular enclave in Fangshan granodiorite, most of the genesis type is probably the result of the xenolith metamorphic transformation.

根据闪长质微粒包体的宏观特征及分布规律、特殊的结构构造、主要造岩矿物与寄主岩的对比以及6187个斜长石双晶类型百分率的成因分析得出,房山花岗闪长岩体中的闪长质微粒包体尽管有多种成因,但有不少可能是捕虏岩包体变质改造的结果。

During strawberry ( Fragaria ananassa Duch cv.chunxing) fruits maturation,the content of total sugar,anthocyanin and respiration rate increased significantly,and Ca 2+ _ATPase activity of cytoplasm and microsome membrane increased firstly,then peaked at pink stage,and decreased at full red stage in fruits,and also,the activity of plasma membrane Ca 2+ _ATPase was the highest in microsome membranes.

'春星'草莓果实成熟时,总糖和花青苷含量增加,呼吸速率也显著升高;同时,细胞溶质Ca2 + _ATPase活性和微粒体膜的Ca2 + _ATPase总活性变化具有相似的特点,即先升高,至粉红期达到高峰,全红期又下降,在微粒体膜中以质膜Ca2 + _ATPase占的比例最高。

[Objective]To study the relativity during polyethelene debris cytokine and loosening of hip prosthesis.[Methods]Thirty eight patients with loosening of hip prosthesis were divided into three group:total hip arthoplasty,double hip arthoplasty and integrated arthoplasty.The inflammative reaction was analyzed with light microscopic observation arrording to the half-ration standard of Joseph,and the content of TNF in samples of interface membranes was determined.

[目的]研究聚乙烯微粒、细胞因子与人工髋关节松动的相关性[方法]根据假体的类型及假体中是否含有聚乙烯将38例人工髋关节翻修病例分 3组:全髋置换组、双动头组和体式单动头组,对各组术中松动假体周围界膜组织进行光镜下炎性细胞计的半定量分析和肿瘤坏死因子的测定,分析人工髋关节无菌性松动与聚乙烯微粒、细胞因子之间的相关关系。

The technique of liver CYP450 enzymes was applied to the in vitro study of drug metabolism In the first part of this article, the metabolism of nimodipine in human liver microsomes was studied and in the second of part of this article the metabolism of clivorine in female rat, guinea pig, human liver microsomes as well as the mechanism of metabolism-induced toxicity were investigated.

运用肝微粒体技术进行药物的体外代谢研究。本论文第一部分运用肝微粒体技术研究了尼莫地平在人肝微粒体内的代谢及其代谢的酶动力学,第二部分研究了肝毒性生物碱Clivorine在大鼠、豚鼠和人肝微粒体内的代谢及其代谢致毒机理。

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According to the clear water experiment, aeration performance of the new equipment is good with high total oxygen transfer coefficient and oxygen utilization ratio.

曝气设备的动力效率在叶轮转速为120rpm~150rpm时取得最大值,此时氧利用率和充氧能力也具有较高值。

The environmental stability of that world - including its crushing pressures and icy darkness - means that some of its most famous inhabitants have survived for eons as evolutionary throwbacks, their bodies undergoing little change.

稳定的海底环境─包括能把人压扁的压力和冰冷的黑暗─意谓海底某些最知名的栖居生物已以演化返祖的样态活了万世,形体几无变化。

When I was in school, the rabbi explained everythingin the Bible two different ways.

当我上学的时候,老师解释《圣经》用两种不同的方法。