微粉化

The present research situation and development of drug micronization and embedment is summarized.

总结了超临界抗溶剂技术在微粉化药物和制备缓释药物微球方面的研究现状和发展。

METHODS: Between November 2003 and January 2004, seven patients, who suffered vocal fold atrophy, underwent micronized AlloDerm injection laryngoplasty and were enrolled in this study. Their ages ranged from 32 to 74 years with a mean age of 44 years.

材料及方法：回溯性地收集2003年11月至2004年1月间，因声带萎缩导致声门闭合不全而接受微粉化AlloDerm注射喉整形术之病患，共有7名（男2，女5），年龄分布32~74岁，平均44岁。

Micronized AlloDerm injection laryngoplasty can improve glottic closure in patients with vocal fold atrophy, but fails to correct a posterior chink. In addition, the volume of AlloDerm seems to reduce as it is transformed into stable tissue.

微粉化AlloDerm注射喉整形术可用於治疗声带萎缩所导致的声门闭合不全，但是，对於后间隙的治疗效果较差；而且，AlloDerm在转化成稳定的组织后，体积会缩减。

A preparation method of ultra-fine danazol powder belongs to the method of drug micronization.

一种超细达那唑粉体的制备方法，属于药物微粉化方法。

Micronization is one of the methods to improve the solubility and bioavailability of drug,the micronization of TCM is a new techonology of TCM mordenization.

微粉化是提高药物溶解度和生物利用度的有效手段之一，中药微粉化是中药现代化新技术的研究热点。

The result shows that the solvent dispersing method has an advantage over micronization method for dissolution uniformity of glibenclamide.

结果与结论溶剂分散法制备的胶囊中格列本脲溶出均一性优于将格列苯脲微粉化制得的胶囊。

Micronization is one of the methods to improve the solubility and bioavailability of drug,the micronization of TCM is a new techonology of TCM mordenization.

中文摘要：微粉化是提高药物溶解度和生物利用度的有效手段之一，中药微粉化是中药现代化新技术的研究热点。

Micronization of irbesartan has been studied using an anti-solvent recrystallization method.

采用反溶剂重结晶法对疏水性药物依贝沙坦了进行微粉化研究。

It is especially discussed that the principle, operation process and effects of the operation parameters on the characteristic of the products when the hydrophilic drug micronized with the supercritical assisted atomization which is an improvement on the supercritical anti-solvent technology. It is also introduced that the embedment of hydrophobic drug into biodegradable materials with the use of surfactant as well as the effect of different molecular weight of carrier and different ratio of complex carrier on the characteristic of products is made. It is pointed out that the use of surfactant will improve the micronization of microparticles of the hydrophobic drugs.

在药物微粉化方面，着重介绍了超临界辅助原子化法对水溶性药物的处理，包括该方法的原理、操作方法以及操作参数对产品性能的影响，证明该方法用于改善水溶性药物的微粉化具有良好的效果；在制备药物微球方面，重点介绍了不同操作条件和不同分子质量的载体、不同配比的复合载体对药物微球性能的影响以及表面活性剂在亲脂性及离子型药物微球制备中的应用，指出添加表面活性剂将更有利于得到该类药物的微球。

Status in quo of TCM micronization was reviewed and analyzed. Effects of micronization on the dissolution of active ingredients and pharmacological action were widely studied,however some fundmental aspects,such as engineering factors of superfine powder preparation,stability of them and the optimal particle size,are urgently to be studied.

作者对国内中药微粉化的现状进行总结分析，发现目前研究主要集中于微粉化对药物有效成分或部位的体外溶出及药效的影响，提出中药微粉化亟待解决的基础性问题有：微粉化制备工程学研究、微粉的稳定性研究、微粉最适粒度的筛选和确定等。

But we don't care about Battlegrounds.

但我们并不在乎沙场中的显露。

Ah! don't mention it, the butcher's shop is a horror.

啊！不用提了。提到肉，真是糟透了。